Unravelling the transcriptomic landscape of the major phase II UDP-glucuronosyltransferase drug metabolizing pathway using targeted RNA sequencing

Pharmacogenomics of Human Uridine Diphospho-Glucuronosyltransferases and Clinical Implications

(2014) C Guillemette et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Genetic factors affecting gene transcription and catalytic activity of UDP-glucuronosyltransferases in human liver

(2014) Wanqing Liu et al.   HUMAN MOLECULAR GENETICS

Comprehensive annotation of splice junctions supports pervasive alternative splicing at the BRCA1 locus: a report from the ENIGMA consortium

(2014) Mara Colombo et al.   HUMAN MOLECULAR GENETICS

AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer

(2014) Emmanuel S. Antonarakis et al.   NEW ENGLAND JOURNAL OF MEDICINE

A dynamic alternative splicing program regulates gene expression during terminal erythropoiesis

(2014) Harold Pimentel et al.   NUCLEIC ACIDS RESEARCH

Two Decades After BRCA: Setting Paradigms in Personalized Cancer Care and Prevention

(2014) F. J. Couch et al.   SCIENCE

Organizing Principles of Mammalian Nonsense-Mediated mRNA Decay

(2013) Maximilian Wei-Lin Popp et al.   Annual Review of Genetics

Importance of 5α-Reductase Gene Polymorphisms on Circulating and Intraprostatic Androgens in Prostate Cancer

(2013) Éric Lévesque et al.   CLINICAL CANCER RESEARCH

Expression of UGT2B7 is driven by two mutually exclusive promoters and alternative splicing in human tissues

(2013) Vincent Ménard et al.   Pharmacogenetics and Genomics

Next-generation sequencing of pharmacogenes

(2013) Britt I. Drögemöller et al.   Pharmacogenetics and Genomics

PharmGKB summary

(2013) Julia M. Barbarino et al.   Pharmacogenetics and Genomics

Relevance of UDP-glucuronosyltransferase polymorphisms for drug dosing: A quantitative systematic review

(2013) J.C. Stingl et al.   PHARMACOLOGY & THERAPEUTICS

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Genome-wide approaches in pharmacogenomics: heritability estimation and pharmacoethnicity as primary challenges

(2012) Eric R Gamazon et al.   PHARMACOGENOMICS

Targeted RNA sequencing reveals the deep complexity of the human transcriptome

(2011) Tim R Mercer et al.   NATURE BIOTECHNOLOGY

Transcriptional diversity at the UGT2B7 locus is dictated by extensive pre-mRNA splicing mechanisms that give rise to multiple mRNA splice variants

(2011) Vincent Ménard et al.   Pharmacogenetics and Genomics

Alternatively Spliced Products of the UGT1A Gene Interact with the Enzymatically Active Proteins to Inhibit Glucuronosyltransferase Activity In Vitro

(2010) J. Bellemare et al.   DRUG METABOLISM AND DISPOSITION

Circulating Estrogens in Endometrial Cancer Cases and Their Relationship with Tissular Expression of Key Estrogen Biosynthesis and Metabolic Pathways

(2010) Johanie Lépine et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Immunohistochemical expression of conjugating UGT1A-derived isoforms in normal and tumoral drug-metabolizing tissues in humans

(2010) Judith Bellemare et al.   JOURNAL OF PATHOLOGY

Extensive splicing of transcripts encoding the bile acid-conjugating enzyme UGT2B4 modulates glucuronidation

(2010) Eric Lévesque et al.   Pharmacogenetics and Genomics

UGT genomic diversity: beyond gene duplication

(2009) Chantal Guillemette et al.   DRUG METABOLISM REVIEWS

Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene

(2009) Federico Innocenti et al.   Pharmacogenetics and Genomics

Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3

(2009) Nina Sneitz et al.   Pharmacogenetics and Genomics