UDP-glucuronosyltransferase 2B15 (UGT2B15) Is the Major Enzyme Responsible for Sipoglitazar Glucuronidation in Humans: Retrospective Identification of the UGT Isoform by In Vitro Analysis and the Effect of UGT2B15*2 Mutation

The effect of genetic polymorphisms in UGT2B15 on the pharmacokinetic profile of sipoglitazar, a novel anti-diabetic agent

(2012) Frances Stringer et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Evaluation of the Impact of UGT Polymorphism on the Pharmacokinetics and Pharmacodynamics of the Novel PPAR Agonist Sipoglitazar

(2012) Frances Stringer et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Metabolic Fate of Sipoglitazar a Novel Oral PPAR Agonist with Activities for PPAR-γ, -α and -δ, in Rats and Monkeys and Comparison with Humans In Vitro

(2011) Mitsuhiro Nishihara et al.   Drug Metabolism and Pharmacokinetics

Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues

(2011) Michael H. Court et al.   XENOBIOTICA

Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A1 enzymes

(2010) Nobumitsu Hanioka et al.   LIFE SCIENCES

Quantitative Analysis of UDP-Glucuronosyltransferase (UGT) 1A and UGT2B Expression Levels in Human Livers

(2009) T. Izukawa et al.   DRUG METABOLISM AND DISPOSITION

UGT genomic diversity: beyond gene duplication

(2009) Chantal Guillemette et al.   DRUG METABOLISM REVIEWS

The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping andin vitro–in vivoextrapolation of drug clearance and drug-drug interaction potential

(2009) John O. Miners et al.   DRUG METABOLISM REVIEWS

Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction

(2008) S. Ohno et al.   DRUG METABOLISM AND DISPOSITION

Update on tools for evaluation of uridine diphosphoglucuronosyltransferase polymorphisms

(2008) Upendra A Argikar et al.   Expert Opinion on Drug Metabolism & Toxicology