Transcriptional regulation of human UDP-glucuronosyltransferase genes

Identification and preliminary characterization of UDP-glucuronosyltransferases catalyzing formation of ethyl glucuronide

(2014) Nicole Schwab et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Protein expression of various hepatic uridine 5′-diphosphate glucuronosyltransferase (UGT) enzymes and their inter-correlations: a meta-analysis

(2014) Brahim Achour et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Regioselective glucuronidation of the isoflavone calycosin by human liver microsomes and recombinant human UDP-glucuronosyltransferases

(2014) Jian-Qing Ruan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Human UGT1A4 and UGT1A3 Conjugate 25-Hydroxyvitamin D3: Metabolite Structure, Kinetics, Inducibility, and Interindividual Variability

(2014) Zhican Wang et al.   ENDOCRINOLOGY

Enantiomer Selective Glucuronidation of the Non-Steroidal Pure Anti-Androgen Bicalutamide by Human Liver and Kidney: Role of the Human UDP-Glucuronosyltransferase (UGT)1A9 Enzyme

(2013) Laurent Grosse et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Epigenetic regulation of the tissue-specific expression of human UDP-glucuronosyltransferase (UGT) 1A10

(2013) Shingo Oda et al.   BIOCHEMICAL PHARMACOLOGY

Characterization of Raloxifene Glucuronidation: Potential Role of UGT1A8 Genotype on Raloxifene Metabolism In Vivo

(2013) D. Sun et al.   Cancer Prevention Research

Hepatic Cell Lines for Drug Hepatotoxicity Testing: Limitations and Strategies to Upgrade their Metabolic Competence by Gene Engineering

(2013) M. Donato et al.   CURRENT DRUG METABOLISM

UDP-glucuronosyltransferase 2B15 (UGT2B15) Is the Major Enzyme Responsible for Sipoglitazar Glucuronidation in Humans: Retrospective Identification of the UGT Isoform by In Vitro Analysis and the Effect of UGT2B15*2 Mutation

(2013) Mitsuhiro Nishihara et al.   Drug Metabolism and Pharmacokinetics

Identification and Characterization of Human UDP-glucuronosyltransferases Responsible for the Glucuronidation of Fraxetin

(2013) Yang-Liu Xia et al.   Drug Metabolism and Pharmacokinetics

Regiospecificity of Human UDP-glucuronosyltransferase Isoforms in Chalcone and Flavanone Glucuronidation Determined by Metal Complexation and Tandem Mass Spectrometry

(2013) Emily D. Niemeyer et al.   JOURNAL OF NATURAL PRODUCTS

Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers

(2013) Umit Yasar et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Targeted Quantitative Proteomics for the Analysis of 14 UGT1As and -2Bs in Human Liver Using NanoUPLC–MS/MS with Selected Reaction Monitoring

(2013) John K. Fallon et al.   JOURNAL OF PROTEOME RESEARCH

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

Variation in Trans-3′-Hydroxycotinine Glucuronidation Does Not Alter the Nicotine Metabolite Ratio or Nicotine Intake

(2013) Andy Z. X. Zhu et al.   PLoS One

dPeak: High Resolution Identification of Transcription Factor Binding Sites from PET and SET ChIP-Seq Data

(2013) Dongjun Chung et al.   PLoS Computational Biology

Fulvestrant up regulates UGT1A4 and MRPs through ERα and c-Myb pathways: a possible primary drug disposition mechanism

(2013) Vineetha K Edavana et al.   SpringerPlus

Surgical Strategy for Liver Cancers in the Era of Effective Chemotherapy

(2013) Junichi Shindoh et al.   Liver Cancer

Protein–protein interactions between the bilirubin-conjugating UDPglucuronosyltransferase UGT1A1 and its shorter isoform 2 regulatory partner derived from alternative splicing

(2012) Mélanie Rouleau et al.   BIOCHEMICAL JOURNAL

Human UDP-glucuronosyltransferases: Feedback loops between substrates and ligands of their transcription factors

(2012) Karl Walter Bock   BIOCHEMICAL PHARMACOLOGY

Identification of Enzymes Responsible for the N-Oxidation of Darexaban Glucuronide, the Pharmacologically Active Metabolite of Darexaban, and the Glucuronidation of Darexaban N-Oxides in Human Liver Microsomes

(2012) Toshifumi Shiraga et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The association between UGT1A7 polymorphism and cancer risk: A meta-analysis

(2012) Shuang-Xi Han et al.   Cancer Epidemiology

Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53

(2012) Ido Goldstein et al.   CARCINOGENESIS

Effect of aflatoxin B1 on UDP-glucuronosyltransferase mRNA expression in HepG2 cells

(2012) Nobumitsu Hanioka et al.   CHEMOSPHERE

Sorafenib Is an Inhibitor of UGT1A1 but Is Metabolized by UGT1A9: Implications of Genetic Variants on Pharmacokinetics and Hyperbilirubinemia

(2012) C. J. Peer et al.   CLINICAL CANCER RESEARCH

UGT1A4*3 Encodes Significantly Increased Glucuronidation of Olanzapine in Patients on Maintenance Treatment and in Recombinant Systems

(2012) T Haslemo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Function, Genetic Polymorphism, and Transcriptional Regulation of Human UDP-glucuronosyltransferase (UGT) 1A1

(2012) Junko Sugatani   Drug Metabolism and Pharmacokinetics

An androgen receptor mutation in the MDA-MB-453 cell line model of molecular apocrine breast cancer compromises receptor activity

(2012) Nicole L Moore et al.   ENDOCRINE-RELATED CANCER

The effect of genetic polymorphisms in UGT2B15 on the pharmacokinetic profile of sipoglitazar, a novel anti-diabetic agent

(2012) Frances Stringer et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

The HepaRG cell line: a uniquein vitrotool for understanding drug metabolism and toxicology in human

(2012) Tommy B Andersson et al.   Expert Opinion on Drug Metabolism & Toxicology

Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors

(2012) J. Wang et al.   GENOME RESEARCH

Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice

(2012) Shujuan Chen et al.   HEPATOLOGY

Protein Kinase Cα and Src Kinase Support Human Prostate-distributed Dihydrotestosterone-metabolizing UDP-glucuronosyltransferase 2B15 Activity

(2012) Sunit K. Chakraborty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combination Anastrozole and Fulvestrant in Metastatic Breast Cancer

(2012) Rita S. Mehta et al.   NEW ENGLAND JOURNAL OF MEDICINE

Factorbook.org: a Wiki-based database for transcription factor-binding data generated by the ENCODE consortium

(2012) J. Wang et al.   NUCLEIC ACIDS RESEARCH

Glucuronidation of trans-3′-hydroxycotinine by UGT2B17 and UGT2B10

(2012) Gang Chen et al.   Pharmacogenetics and Genomics

Anti-Cancer Drugs Elicit Re-Expression of UDP-Glucuronosyltransferases in Melanoma Cells

(2012) Ryan W. Dellinger et al.   PLoS One

Prostate Cancer with Variants in CYP17 and UGT2B17 Genes: A Meta-Analysis

(2012) Lai Cai et al.   PROTEIN AND PEPTIDE LETTERS

Highly variable pH effects on the interaction of diclofenac and indomethacin with human UDP-glucuronosyltransferases

(2012) Hongbo Zhang et al.   TOXICOLOGY IN VITRO

Protein quantification of UDP-glucuronosyltransferases 1A1 and 2B7 in human liver microsomes by LC-MS/MS and correlation with glucuronidation activities

(2012) Yuichiro Sato et al.   XENOBIOTICA

Quantitation of UGT1A1 in human liver microsomes using stable isotope-labelled peptides and mass spectrometry based proteomic approaches

(2012) Chitra Sridar et al.   XENOBIOTICA

Quantification of Human Uridine-Diphosphate Glucuronosyl Transferase 1A Isoforms in Liver, Intestine, and Kidney Using Nanobore Liquid Chromatography–Tandem Mass Spectrometry

(2011) David E. Harbourt et al.   ANALYTICAL CHEMISTRY

From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans

(2011) Karl Walter Bock   BIOCHEMICAL PHARMACOLOGY

Identification and Regulation of c-Myb Target Genes in MCF-7 Cells

(2011) Anita M Quintana et al.   BMC CANCER

Genetic Polymorphisms of UGT1A7 and Cancer Risk: Evidence From 21 Case–Control Studies

(2011) Pei-Hua Lu et al.   CANCER INVESTIGATION

Functional and Mechanistic Diversity of Distal Transcription Enhancers

(2011) Michael Bulger et al.   CELL

A Novel Method for the Immunoquantification of UDP-Glucuronosyltransferases in Human Tissue

(2011) A. M. Milne et al.   DRUG METABOLISM AND DISPOSITION

Hepatic UDP-Glucuronosyltransferase Is Responsible for Eslicarbazepine Glucuronidation

(2011) A. I. Loureiro et al.   DRUG METABOLISM AND DISPOSITION

Identification of the Human UDP-glucuronosyltransferase Isoforms Involved in the Glucuronidation of the Phytochemical Ferulic Acid

(2011) Xiaojun Li et al.   Drug Metabolism and Pharmacokinetics

FOXA1: master of steroid receptor function in cancer

(2011) Michael A Augello et al.   EMBO JOURNAL

Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1

(2011) Jessica L L Robinson et al.   EMBO JOURNAL

Resveratrol in combination with other dietary polyphenols concomitantly enhances antiproliferation and UGT1A1 induction in Caco-2 cells

(2011) Otito F. Iwuchukwu et al.   LIFE SCIENCES

Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells

(2011) Agnes Basseville et al.   Molecular Cancer

Inhibition of Human UGT2B7 Gene Expression in Transgenic Mice by the Constitutive Androstane Receptor

(2011) M. F. Yueh et al.   MOLECULAR PHARMACOLOGY

Regioselective Glucuronidation of Flavonols by Six Human UGT1A Isoforms

(2011) Baojian Wu et al.   PHARMACEUTICAL RESEARCH

Transcriptional diversity at the UGT2B7 locus is dictated by extensive pre-mRNA splicing mechanisms that give rise to multiple mRNA splice variants

(2011) Vincent Ménard et al.   Pharmacogenetics and Genomics

In vitrointeraction of a novel neutrophil growth factor with human liver microsomal cytochromes P450 and the contribution of UDP-glucuronosyltransferases to its metabolism

(2011) Michal Šiller et al.   XENOBIOTICA

Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues

(2011) Michael H. Court et al.   XENOBIOTICA

N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases

(2011) Sanna Kaivosaari et al.   XENOBIOTICA

Functions and transcriptional regulation of adult human hepatic UDP-glucuronosyl-transferases (UGTs): Mechanisms responsible for interindividual variation of UGT levels

(2010) Karl Walter Bock   BIOCHEMICAL PHARMACOLOGY

UDP-glucuronosyltransferase 1A6 overexpression in breast cancer cells resistant to methotrexate

(2010) M. Cristina de Almagro et al.   BIOCHEMICAL PHARMACOLOGY

is-rSNP: a novel technique for in silico regulatory SNP detection

(2010) Geoff Macintyre et al.   BIOINFORMATICS

Combined effect of regulatory polymorphisms on transcription of UGT1A1 as a cause of Gilbert syndrome

(2010) Katsuyuki Matsui et al.   BMC GASTROENTEROLOGY

Regulation of UGT1A1 and HNF1 transcription factor gene expression by DNA methylation in colon cancer cells

(2010) Anne-Sophie Belanger et al.   BMC MOLECULAR BIOLOGY

In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole

(2010) Landry K. Kamdem et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Genetic Variation of Genes Involved in Dihydrotestosterone Metabolism and the Risk of Prostate Cancer

(2010) S. R. Setlur et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Glucuronidation Genotypes and Nicotine Metabolic Phenotypes: Importance of Functional UGT2B10 and UGT2B17 Polymorphisms

(2010) G. Chen et al.   CANCER RESEARCH

Enhanced steatosis by nuclear receptor ligands: A study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile

(2010) Marta Moya et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Forkhead Box Protein A1 Regulates UDP-Glucuronosyltransferase 2B15 Gene Transcription in LNCaP Prostate Cancer Cells

(2010) D. G. Hu et al.   DRUG METABOLISM AND DISPOSITION

Role of Human UGT2B10 in N-Glucuronidation of Tricyclic Antidepressants, Amitriptyline, Imipramine, Clomipramine, and Trimipramine

(2010) D. Zhou et al.   DRUG METABOLISM AND DISPOSITION

A Humanized UGT1 Mouse Model Expressing the UGT1A1*28 Allele for Assessing Drug Clearance by UGT1A1-Dependent Glucuronidation

(2010) H. Cai et al.   DRUG METABOLISM AND DISPOSITION

Phase II Metabolism of Hesperetin by Individual UDP-Glucuronosyltransferases and Sulfotransferases and Rat and Human Tissue Samples

(2010) W. Brand et al.   DRUG METABOLISM AND DISPOSITION

Identification of the Human UDP-Glucuronosyltransferases Involved in the Glucuronidation of Combretastatin A-4

(2010) S. Aprile et al.   DRUG METABOLISM AND DISPOSITION

Role of UDP-Glucuronosyltransferase Isoforms in 13-cis Retinoic Acid Metabolism in Humans

(2010) S. E. Rowbotham et al.   DRUG METABOLISM AND DISPOSITION

Shared Regulation of UGT1A7 by Hepatocyte Nuclear Factor (HNF) 1  and HNF4 

(2010) U. Ehmer et al.   DRUG METABOLISM AND DISPOSITION

Metabolic Pathways of the Camptothecin Analog AR-67

(2010) J. Horn et al.   DRUG METABOLISM AND DISPOSITION

Dabigatran Acylglucuronide, the Major Human Metabolite of Dabigatran: In Vitro Formation, Stability, and Pharmacological Activity

(2010) T. Ebner et al.   DRUG METABOLISM AND DISPOSITION

Alternatively Spliced Products of the UGT1A Gene Interact with the Enzymatically Active Proteins to Inhibit Glucuronosyltransferase Activity In Vitro

(2010) J. Bellemare et al.   DRUG METABOLISM AND DISPOSITION

Metabolism of 1'- and 4-Hydroxymidazolam by Glucuronide Conjugation Is Largely Mediated by UDP-Glucuronosyltransferases 1A4, 2B4, and 2B7

(2010) K.-A. Seo et al.   DRUG METABOLISM AND DISPOSITION

Regulated Phosphorylation of a Major UDP-glucuronosyltransferase Isozyme by Tyrosine Kinases Dictates Endogenous Substrate Selection for Detoxification

(2010) Partha S. Mitra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide Analysis of CDX2 Binding in Intestinal Epithelial Cells (Caco-2)

(2010) Mette Boyd et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction between Oxidative Stress Sensor Nrf2 and Xenobiotic-activated Aryl Hydrocarbon Receptor in the Regulation of the Human Phase II Detoxifying UDP-glucuronosyltransferase 1A10

(2010) Sandra Kalthoff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the human bile acid UDP-glucuronosyltransferase 1A3 by the farnesoid X receptor and bile acids

(2010) Thomas J. Erichsen et al.   JOURNAL OF HEPATOLOGY

Identification and Characterization of Oxymetazoline Glucuronidation in Human Liver Microsomes: Evidence for the Involvement of UGT1A9

(2010) Mukesh K. Mahajan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

In Vitro-In Vivo Extrapolation Predicts Drug-Drug Interactions Arising from Inhibition of Codeine Glucuronidation by Dextropropoxyphene, Fluconazole, Ketoconazole, and Methadone in Humans

(2010) P. Raungrut et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Glucuronidation of piceatannol by human liver microsomes: major role of UGT1A1, UGT1A8 and UGT1A10

(2010) Michaela Miksits et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Structure-metabolism relationships for the glucuronidation of flavonoids by UGT1A3 and UGT1A9

(2010) Shenggu Xie et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

A Novel Polymorphism in a Forkhead Box A1 (FOXA1) Binding Site of the Human UDP Glucuronosyltransferase 2B17 Gene Modulates Promoter Activity and Is Associated with Altered Levels of Circulating Androstane-3 ,17 -diol Glucuronide

(2010) D. G. Hu et al.   MOLECULAR PHARMACOLOGY

A pharmacogenetic study of vorinostat glucuronidation

(2010) Soonmo Peter Kang et al.   Pharmacogenetics and Genomics

Extensive splicing of transcripts encoding the bile acid-conjugating enzyme UGT2B4 modulates glucuronidation

(2010) Eric Lévesque et al.   Pharmacogenetics and Genomics

Characterization of 17-dihydroexemestane glucuronidation: potential role of the UGT2B17 deletion in exemestane pharmacogenetics

(2010) Dongxiao Sun et al.   Pharmacogenetics and Genomics

Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus

(2010) R. Fujiwara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SVA retrotransposons: Evolution and genetic instability

(2010) Dustin C. Hancks et al.   SEMINARS IN CANCER BIOLOGY

HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro

(2010) Marc Lübberstedt et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Src supports UDP-glucuronosyltransferase-2B7 detoxification of catechol estrogens associated with breast cancer

(2009) Partha S. Mitra et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: Inhibition by NSAIDs

(2009) Kathleen M. Knights et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Evidence for oxazepam as anin vivoprobe of UGT2B15: oxazepam clearance is reduced byUGT2B15D85Y polymorphism but unaffected byUGT2B17deletion

(2009) Xi He et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

miR-21: An Androgen Receptor-Regulated MicroRNA that Promotes Hormone-Dependent and Hormone-Independent Prostate Cancer Growth

(2009) J. Ribas et al.   CANCER RESEARCH

Characterization of UGTs Active against SAHA and Association between SAHA Glucuronidation Activity Phenotype with UGT Genotype

(2009) R. M. Balliet et al.   CANCER RESEARCH

4-Hydroxy-3-methoxymethamphetamine Glucuronide as a Phase II Metabolite of 3,4-Methylenedioxymethamphetamine: Enzyme-Assisted Synthesis and Involvement of Human Hepatic Uridine 5′-Diphosphate-Glucuronosyltransferase 2B15 in the Glucuronidation

(2009) Takuji Shoda et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Glucuronidation of Dihydrotestosterone and trans-Androsterone by Recombinant UDP-Glucuronosyltransferase (UGT) 1A4: Evidence for Multiple UGT1A4 Aglycone Binding Sites

(2009) J. Zhou et al.   DRUG METABOLISM AND DISPOSITION

Quantitative Analysis of UDP-Glucuronosyltransferase (UGT) 1A and UGT2B Expression Levels in Human Livers

(2009) T. Izukawa et al.   DRUG METABOLISM AND DISPOSITION

Identification of Human UGT2B7 as the Major Isoform Involved in the O-Glucuronidation of Chloramphenicol

(2009) M. Chen et al.   DRUG METABOLISM AND DISPOSITION

Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids

(2009) A. Mazur et al.   DRUG METABOLISM AND DISPOSITION

Glucuronidation of the Antiretroviral Drug Efavirenz by UGT2B7 and an in Vitro Investigation of Drug-Drug Interaction with Zidovudine

(2009) A.-S. Belanger et al.   DRUG METABOLISM AND DISPOSITION

The Role of Human UDP-Glucuronyltransferases on the Formation of the Methylenedioxymethamphetamine (Ecstasy) Phase II Metabolites R- and S-3-Methoxymethamphetamine 4-O-Glucuronides

(2009) A. E. Schwaninger et al.   DRUG METABOLISM AND DISPOSITION

Up-Regulation of UDP-Glucuronosyltransferase (UGT) 1A4 by 17 -Estradiol: A Potential Mechanism of Increased Lamotrigine Elimination in Pregnancy

(2009) H. Chen et al.   DRUG METABOLISM AND DISPOSITION

Regulation of endobiotics glucuronidation by ligand-activated transcription factors: physiological function and therapeutic potential

(2009) Mélanie Verreault et al.   DRUG METABOLISM REVIEWS

Use of transgenic mice in UDP-glucuronosyltransferase (UGT) studies

(2009) Zhimin Ou et al.   DRUG METABOLISM REVIEWS

UGT genomic diversity: beyond gene duplication

(2009) Chantal Guillemette et al.   DRUG METABOLISM REVIEWS

The regulation of UDP-glucuronosyltransferase genes by tissue-specific and ligand-activated transcription factors

(2009) Peter I. Mackenzie et al.   DRUG METABOLISM REVIEWS

Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system

(2009) Michael H. Court   DRUG METABOLISM REVIEWS

Genetic polymorphisms in the tobacco smoke carcinogens detoxifying enzyme UGT1A7 and the risk of head and neck cancer

(2009) Martin Lacko et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Increased caffeine consumption is associated with reduced hepatic fibrosis

(2009) Apurva A. Modi et al.   HEPATOLOGY

Copy-number variations (CNVs) of the human sex steroid metabolizing genesUGT2B17andUGT2B28and their associations with aUGT2B15functional polymorphism

(2009) Vincent Ménard et al.   HUMAN MUTATION

Allelic imbalance (AI) identifies novel tissue-specificcis-regulatory variation for humanUGT2B15

(2009) Chang Sun et al.   HUMAN MUTATION

Modulation of the Human Glucuronosyltransferase UGT1A Pathway by Splice Isoform Polypeptides Is Mediated through Protein-Protein Interactions

(2009) Judith Bellemare et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinate regulation of metabolic enzymes and transporters by nuclear transcription factors in human liver disease

(2009) Mario Congiu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Lipid-activated transcription factors control bile acid glucuronidation

(2009) Olivier Barbier et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Estrogen Receptor  , Fos-Related Antigen-2, and c-Jun Coordinately Regulate Human UDP Glucuronosyltransferase 2B15 and 2B17 Expression in Response to 17 -Estradiol in MCF-7 Cells

(2009) D. G. Hu et al.   MOLECULAR PHARMACOLOGY

Dietary phenolics: chemistry, bioavailability and effects on health

(2009) Alan Crozier et al.   NATURAL PRODUCT REPORTS

Microarray coupled to quantitative RT–PCR analysis of androgen-regulated genes in human LNCaP prostate cancer cells

(2009) S Ngan et al.   ONCOGENE

Genetic polymorphisms in the 5′-flanking region of human UDP-glucuronosyltransferase 2B7 affect the Nrf2-dependent transcriptional regulation

(2009) Akiko Nakamura et al.   Pharmacogenetics and Genomics

A pharmacogenetics study of the human glucuronosyltransferase UGT1A4

(2009) Marie-Odile Benoit-Biancamano et al.   Pharmacogenetics and Genomics

Alternative-splicing forms of the major phase II conjugating UGT1A gene negatively regulate glucuronidation in human carcinoma cell lines

(2009) J Bellemare et al.   PHARMACOGENOMICS JOURNAL

Aryl hydrocarbon receptor-mediated regulation of the human estrogen and bile acid UDP-glucuronosyltransferase 1A3 gene

(2008) Tim O. Lankisch et al.   ARCHIVES OF TOXICOLOGY

Inactivation of androgens by UDP-glucuronosyltransferases in the human prostate

(2008) Olivier Barbier et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

UDP-glucuronosyltransferases 1A6 and 1A10 catalyze reduced menadione glucuronidation

(2008) Takahito Nishiyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells

(2008) Jenny Kaeding et al.   BIOCHEMICAL JOURNAL

Glucuronidation of flavonoids by recombinant UGT1A3 and UGT1A9

(2008) Yakun Chen et al.   BIOCHEMICAL PHARMACOLOGY

The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan

(2008) Anna Alonen et al.   BIOCHEMICAL PHARMACOLOGY

UGT1A6 genotype-related pharmacokinetics of deferiprone (L1) in healthy volunteers

(2008) Lie Michael George Limenta et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Clinical and pharmacogenetic factors associated with irinotecan toxicity

(2008) Dinemarie Kweekel et al.   CANCER TREATMENT REVIEWS

FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription

(2008) Mathieu Lupien et al.   CELL

Environmental sensing and response genes in cnidaria: the chemical defensome in the sea anemone Nematostella vectensis

(2008) J. V. Goldstone   CELL BIOLOGY AND TOXICOLOGY

Farnesoid X Receptor Induces GLUT4 Expression Through FXR Response Element in the GLUT4 Promoter

(2008) Hong Shen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Human UDP-glucuronosyltransferase isoforms involved in bisphenol A glucuronidation

(2008) Nobumitsu Hanioka et al.   CHEMOSPHERE

Liver-Enriched Transcription Factors and Their Role in Regulating UDP Glucuronosyltransferase Gene Expression

(2008) D. Gardner-Stephen et al.   CURRENT DRUG METABOLISM

Cell Lines: A Tool for In Vitro Drug Metabolism Studies

(2008) M. Gomez-Lechon et al.   CURRENT DRUG METABOLISM

Glucuronidation of Tobacco-Specific Nitrosamines by UGT2B10

(2008) G. Chen et al.   DRUG METABOLISM AND DISPOSITION

Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction

(2008) S. Ohno et al.   DRUG METABOLISM AND DISPOSITION

Expression of UGT1A and UGT2B mRNA in Human Normal Tissues and Various Cell Lines

(2008) A. Nakamura et al.   DRUG METABOLISM AND DISPOSITION

The Configuration of the 17-Hydroxy Group Variably Influences the Glucuronidation of  -Estradiol and Epiestradiol by Human UDP-Glucuronosyltransferases

(2008) K. Itaaho et al.   DRUG METABOLISM AND DISPOSITION

Deferiprone Glucuronidation by Human Tissues and Recombinant UDP Glucuronosyltransferase 1A6: An in Vitro Investigation of Genetic and Splice Variants

(2008) M.-O. Benoit-Biancamano et al.   DRUG METABOLISM AND DISPOSITION

Effect of Aging on Glucuronidation of Valproic Acid in Human Liver Microsomes and the Role of UDP-Glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10

(2008) U. A. Argikar et al.   DRUG METABOLISM AND DISPOSITION

Evaluation of HepaRG Cells as an in Vitro Model for Human Drug Metabolism Studies

(2008) K. P. Kanebratt et al.   DRUG METABOLISM AND DISPOSITION

The Major Chemical-detoxifying System of UDP-glucuronosyltransferases Requires Regulated Phosphorylation Supported by Protein Kinase C

(2008) Nikhil K. Basu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation by UDP-glucuronosyltransferase enzymes: The end of androgen signaling

(2008) Sarah Chouinard et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Calcitrol (1 ,25-dihydroxyvitamin D3) inhibits androgen glucuronidation in prostate cancer cells

(2008) J. Kaeding et al.   MOLECULAR CANCER THERAPEUTICS

Metabolism and Renal Elimination of Gaboxadol in Humans: Role of UDP-Glucuronosyltransferases and Transporters

(2008) Xiao-Yan Chu et al.   PHARMACEUTICAL RESEARCH

Stereoselective Glucuronidation of Propranolol in Human and Cynomolgus Monkey Liver Microsomes: Role of Human Hepatic UDP-Glucuronosyltransferase Isoforms, UGT1A9, UGT2B4 and UGT2B7

(2008) Nobumitsu Hanioka et al.   PHARMACOLOGY

Androgen receptor mediates the expression of UDP-glucuronosyltransferase 2 B15 and B17 genes

(2008) Bo-Ying Bao et al.   PROSTATE

TheUGT2B17gene deletion is not associated with prostate cancer risk

(2008) Mats Olsson et al.   PROSTATE

Identification of UDP-glucuronosyltransferase 1A10 in non-malignant and malignant human breast tissues

(2008) Athena Starlard-Davenport et al.   STEROIDS

Genetic variability of aryl hydrocarbon receptor (AhR)-mediated regulation of the human UDP glucuronosyltransferase (UGT) 1A4 gene

(2008) Thomas J. Erichsen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Novel identification of UDP-glucuronosyltransferase 1A10 as an estrogen-regulated target gene

(2007) Athena Starlard-Davenport et al.   STEROIDS