Type 1 diabetes pathogenesis and the role of inhibitory receptors in islet tolerance

Self-Reactive B Cells in the Germinal Center Reaction

(2018) Robert Brink et al.   Annual Review of Immunology

CD4 T Cells Reactive to Hybrid Insulin Peptides are Indicators of Disease Activity in the NOD Mouse

(2018) Rocky L. Baker et al.   DIABETES

Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors

(2018) Angeliki M. Stamatouli et al.   DIABETES

A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk

(2018) Maria J. Redondo et al.   DIABETES CARE

Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA1cin New-Onset Type 1 Diabetes

(2018) Michael J. Haller et al.   DIABETES CARE

LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells

(2018) Andreia C. Lino et al.   IMMUNITY

Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function

(2018) Peter T. Sage et al.   JOURNAL OF IMMUNOLOGY

Thymic tolerance as a key brake on autoimmunity

(2018) Mickie Cheng et al.   NATURE IMMUNOLOGY

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node

(2018) Ruby Alonso et al.   Nature Communications

Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes

(2018) Kevin C. Osum et al.   Scientific Reports

Pathogenic citrulline-multispecific B cell receptor clades in rheumatoid arthritis

(2018) Philip J Titcombe et al.   Arthritis & Rheumatology

Signal Transducer and Activator of Transcription 3 Hyperactivation Associates With Follicular Helper T Cell Differentiation and Disease Activity in Rheumatoid Arthritis

(2018) Jun Deng et al.   Frontiers in Immunology

The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future

(2018) Yi-Guang Chen et al.   Frontiers in Endocrinology

PD-1 Controls Follicular T Helper Cell Positioning and Function

(2018) Jingwen Shi et al.   IMMUNITY

Interleukin-10 Producing Regulatory B Cells Transformed CD4+CD25− Into Tregs and Enhanced Regulatory T Cells Function in Human Leprosy

(2018) Mohd. Tarique et al.   Frontiers in Immunology

Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3

(2018) Jun Wang et al.   CELL

Imbalance of circulating Tfr/Tfh ratio in patients with rheumatoid arthritis

(2018) Xiuzhen Wang et al.   CLINICAL AND EXPERIMENTAL MEDICINE

LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII

(2018) Takumi Maruhashi et al.   NATURE IMMUNOLOGY

Treg cells—the next frontier of cell therapy

(2018) Jeffrey A. Bluestone et al.   SCIENCE

LAG3 (CD223) as a cancer immunotherapy target

(2017) Lawrence P. Andrews et al.   IMMUNOLOGICAL REVIEWS

An insulin-IAPP hybrid peptide is an endogenous antigen for CD4 T cells in the non-obese diabetic mouse

(2017) Timothy A. Wiles et al.   JOURNAL OF AUTOIMMUNITY

Human regulatory B cells in health and disease: therapeutic potential

(2017) Claudia Mauri et al.   JOURNAL OF CLINICAL INVESTIGATION

Ectopic Expression of Self-Antigen Drives Regulatory T Cell Development and Not Deletion of Autoimmune T Cells

(2017) Thomas Lee et al.   JOURNAL OF IMMUNOLOGY

Relationship between CD4 Regulatory T Cells and Anergy In Vivo

(2017) Lokesh A. Kalekar et al.   JOURNAL OF IMMUNOLOGY

Type 1 diabetes induction in humanized mice

(2017) Shulian Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

(2017) Enfu Hui et al.   SCIENCE

Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

(2017) Alice O. Kamphorst et al.   SCIENCE

Directing T cell fate: How thymic antigen presenting cells coordinate thymocyte selection

(2017) Elise R. Breed et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Regulatory B cells: Phenotype, function and role in transplantation

(2017) CM Wortel et al.   TRANSPLANT IMMUNOLOGY

CD8+ T cells specific for the islet autoantigen IGRP are restricted in their T cell receptor chain usage

(2017) Yannick F. Fuchs et al.   Scientific Reports

T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes

(2017) Adam L. Burrack et al.   Frontiers in Endocrinology

Mechanisms of Regulatory B cell Function in Autoimmune and Inflammatory Diseases beyond IL-10

(2017) Avijit Ray et al.   Journal of Clinical Medicine

Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes

(2016) Pia Leete et al.   DIABETES

Circulating CXCR5 + PD-1 + ICOS + Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodies

(2016) Tyyne Viisanen et al.   DIABETES

Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes

(2016) Aaron W. Michels et al.   DIABETES

Antithymocyte globulin therapy for patients with recent-onset type 1 diabetes: 2 year results of a randomised trial

(2016) Stephen E. Gitelman et al.   DIABETOLOGIA

Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage

(2016) Sven Malchow et al.   IMMUNITY

Thymus-Derived Regulatory T Cells Are Positively Selected on Natural Self-Antigen through Cognate Interactions of High Functional Avidity

(2016) Elisa Kieback et al.   IMMUNITY

Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis

(2016) Andrea Schietinger et al.   IMMUNITY

Co-stimulatory and Co-inhibitory Pathways in Autoimmunity

(2016) Qianxia Zhang et al.   IMMUNITY

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion

(2016) Bertram Bengsch et al.   IMMUNITY

Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites

(2016) Xiaoxiao Wan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expanding antigen-specific regulatory networks to treat autoimmunity

(2016) Xavier Clemente-Casares et al.   NATURE

CD4+ T cell anergy prevents autoimmunity and generates regulatory T cell precursors

(2016) Lokesh A Kalekar et al.   NATURE IMMUNOLOGY

Tolerance is established in polyclonal CD4+ T cells by distinct mechanisms, according to self-peptide expression patterns

(2016) Deepali Malhotra et al.   NATURE IMMUNOLOGY

Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

(2016) Jenny Aurielle B Babon et al.   NATURE MEDICINE

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion

(2016) T. Delong et al.   SCIENCE

The epigenetic landscape of T cell exhaustion

(2016) D. R. Sen et al.   SCIENCE

Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment

(2016) Justin A. Spanier et al.   Nature Communications

Characterization of T follicular helper cells in allogeneic normal pregnancy and PDL1 blockage-induced abortion

(2016) Weihong Zeng et al.   Scientific Reports

Spatiotemporal Dynamics of Insulitis in Human Type 1 Diabetes

(2016) Kyle C. A. Wedgwood et al.   Frontiers in Physiology

Transcription factors and target genes of pre-TCR signaling

(2015) Cristina López-Rodríguez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

(2015) Martha Campbell-Thompson et al.   DIABETES

IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients

(2015) Ricardo C. Ferreira et al.   DIABETOLOGIA

Mouse pancreatic beta cells express MHC class II and stimulate CD4+T cells to proliferate

(2015) Yuxing Zhao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Central tolerance spares the private high-avidity CD4+T-cell repertoire specific for an islet antigen in NOD mice

(2015) Laurent Serre et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The regulatory role of B cells in autoimmunity, infections and cancer: Perspectives beyond IL10 production

(2015) Melisa Gorosito Serrán et al.   FEBS LETTERS

Antibody Effector Functions Mediated by Fcγ-Receptors Are Compromised during Persistent Viral Infection

(2015) Andreas Wieland et al.   IMMUNITY

Regulatory B Cells: Origin, Phenotype, and Function

(2015) Elizabeth C. Rosser et al.   IMMUNITY

Perforin facilitates beta cell killing and regulates autoreactive CD8+ T-cell responses to antigen in mouse models of type 1 diabetes

(2015) Prerak Trivedi et al.   IMMUNOLOGY AND CELL BIOLOGY

PD-1 Deficiency Enhances Humoral Immunity of Malaria Infection Treatment Vaccine

(2015) Taiping Liu et al.   INFECTION AND IMMUNITY

Pooled Analysis of Long-Term Survival Data From Phase II and Phase III Trials of Ipilimumab in Unresectable or Metastatic Melanoma

(2015) Dirk Schadendorf et al.   JOURNAL OF CLINICAL ONCOLOGY

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity

(2015) Alison M. Paterson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Heterogeneity and Lobularity of Pancreatic Pathology in Type 1 Diabetes during the Prediabetic Phase

(2015) Teresa Rodriguez-Calvo et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Cutting Edge: Identification of Autoreactive CD4+and CD8+T Cell Subsets Resistant to PD-1 Pathway Blockade

(2015) Kristen E. Pauken et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Nonobese Diabetic Mice Deficient in Chromogranin A Are Protected from Autoimmune Diabetes

(2015) Rocky L. Baker et al.   JOURNAL OF IMMUNOLOGY

Targeting Anti-Insulin B Cell Receptors Improves Receptor Editing in Type 1 Diabetes–Prone Mice

(2015) Rachel H. Bonami et al.   JOURNAL OF IMMUNOLOGY

Immunogenetics of type 1 diabetes mellitus

(2015) Michael P. Morran et al.   MOLECULAR ASPECTS OF MEDICINE

T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

(2015) Eoin F. McKinney et al.   NATURE

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

PD-1/PD-L1 Costimulatory Pathway-induced Mouse Islet Transplantation Immune Tolerance

(2015) T. Li et al.   TRANSPLANTATION PROCEEDINGS

Confusing signals: Recent progress in CTLA-4 biology

(2015) Lucy S.K. Walker et al.   TRENDS IN IMMUNOLOGY

Overcoming T cell exhaustion in infection and cancer

(2015) Kristen E. Pauken et al.   TRENDS IN IMMUNOLOGY

T follicular regulatory cells in the regulation of B cell responses

(2015) Peter T. Sage et al.   TRENDS IN IMMUNOLOGY

PD-L1hi B cells are critical regulators of humoral immunity

(2015) Adnan R. Khan et al.   Nature Communications

Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells

(2015) T. Kouo et al.   Cancer Immunology Research

LSECtin Expressed on Melanoma Cells Promotes Tumor Progression by Inhibiting Antitumor T-cell Responses

(2014) F. Xu et al.   CANCER RESEARCH

PD-L1–Driven Tolerance Protects Neurogenin3-Induced Islet Neogenesis to Reverse Established Type 1 Diabetes in NOD Mice

(2014) Rongying Li et al.   DIABETES

Loss of Anergic B Cells in Prediabetic and New-Onset Type 1 Diabetic Patients

(2014) Mia J. Smith et al.   DIABETES

Low-Dose Otelixizumab Anti-CD3 Monoclonal Antibody DEFEND-1 Study: Results of the Randomized Phase III Study in Recent-Onset Human Type 1 Diabetes

(2014) Ronnie Aronson et al.   DIABETES CARE

PD-L1 gene polymorphisms and low serum level of PD-L1 protein are associated to type 1 diabetes in Chile

(2014) Carolina Pizarro et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Both retention and recirculation contribute to long-lived regulatory T-cell accumulation in the thymus

(2014) EnJun Yang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Molecular and Transcriptional Basis of CD4+ T Cell Dysfunction during Chronic Infection

(2014) Alison Crawford et al.   IMMUNITY

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

Functional cytotoxic T lymphocytes against IGRP206-214 predict diabetes in the non-obese diabetic mouse

(2014) Hyun-Ja Ko et al.   IMMUNOLOGY AND CELL BIOLOGY

Islet inflammation in human type 1 diabetes mellitus

(2014) Noel G. Morgan et al.   IUBMB LIFE

Prevalence of Type 1 and Type 2 Diabetes Among Children and Adolescents From 2001 to 2009

(2014) Dana Dabelea et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Follicular helper T cell signature in type 1 diabetes

(2014) Rupert Kenefeck et al.   JOURNAL OF CLINICAL INVESTIGATION

Prolonged antigen presentation by immune complex–binding dendritic cells programs the proliferative capacity of memory CD8 T cells

(2014) Beatriz León et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Through Regulation of TCR Expression Levels, an Idd7 Region Gene(s) Interactively Contributes to the Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in Nonobese Diabetic Mice

(2014) D. V. Serreze et al.   JOURNAL OF IMMUNOLOGY

TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity

(2014) V. Lampropoulou et al.   JOURNAL OF IMMUNOLOGY

Reduced Regulatory T Cell Diversity in NOD Mice Is Linked to Early Events in the Thymus

(2014) C. Ferreira et al.   JOURNAL OF IMMUNOLOGY

TCR Affinity and Tolerance Mechanisms Converge To Shape T Cell Diabetogenic Potential

(2014) Maria Bettini et al.   JOURNAL OF IMMUNOLOGY

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

(2014) Ping Shen et al.   NATURE

Protein kinase C-η controls CTLA-4–mediated regulatory T cell function

(2014) Kok-Fai Kong et al.   NATURE IMMUNOLOGY

Lymphocyte Activation Gene-3 (LAG-3) Negatively Regulates Environmentally-Induced Autoimmunity

(2014) Vibha Jha et al.   PLoS One

Lymphocyte Activation Gene 3 (LAG-3) Modulates the Ability of CD4 T-cells to Be Suppressed In Vivo

(2014) Nicholas M. Durham et al.   PLoS One

Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes

(2014) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement

(2014) Chun Jing Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity

(2014) Z. Sabouri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of self-reactive CD8+T cells with an anergic phenotype in healthy individuals

(2014) Yuka Maeda et al.   SCIENCE

Genetic deletion of granzyme B does not confer resistance to the development of spontaneous diabetes in non-obese diabetic mice

(2013) M. Kobayashi et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

PD-1, but Not PD-L1, Expressed by Islet-Reactive CD4 + T Cells Suppresses Infiltration of the Pancreas During Type 1 Diabetes

(2013) Kristen E. Pauken et al.   DIABETES

Teplizumab (Anti-CD3 mAb) Treatment Preserves C-Peptide Responses in Patients With New-Onset Type 1 Diabetes in a Randomized Controlled Trial: Metabolic and Immunologic Features at Baseline Identify a Subgroup of Responders

(2013) K. C. Herold et al.   DIABETES

Teplizumab Preserves C-Peptide in Recent-Onset Type 1 Diabetes: Two-Year Results From the Randomized, Placebo-Controlled Protege Trial

(2013) W. Hagopian et al.   DIABETES

Costimulation Modulation With Abatacept in Patients With Recent-Onset Type 1 Diabetes: Follow-up 1 Year After Cessation of Treatment

(2013) Tihamer Orban et al.   DIABETES CARE

Efficacy and safety of low-dose otelixizumab anti-CD3 monoclonal antibody in preserving C-peptide secretion in adolescent type 1 diabetes: DEFEND-2, a randomized, placebo-controlled, double-blind, multi-centre study

(2013) P. Ambery et al.   DIABETIC MEDICINE

The Prevalence of Type 1 Diabetes in the United States

(2013) Andy Menke et al.   EPIDEMIOLOGY

Extrathymic Aire-Expressing Cells Are a Distinct Bone Marrow-Derived Population that Induce Functional Inactivation of CD4+ T Cells

(2013) James M. Gardner et al.   IMMUNITY

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

(2013) Tyler R. Simpson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The B7-Independent Isoform of CTLA-4 Functions To Regulate Autoimmune Diabetes

(2013) M. Stumpf et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Type 1 Diabetes Occurs despite Robust Anergy among Endogenous Insulin-Specific CD4 T Cells in NOD Mice

(2013) K. E. Pauken et al.   JOURNAL OF IMMUNOLOGY

B Lymphocyte "Original Sin" in the Bone Marrow Enhances Islet Autoreactivity in Type 1 Diabetes-Prone Nonobese Diabetic Mice

(2013) R. A. Henry-Bonami et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: CD4 T Cells Reactive to an Islet Amyloid Polypeptide Peptide Accumulate in the Pancreas and Contribute to Disease Pathogenesis in Nonobese Diabetic Mice

(2013) R. L. Baker et al.   JOURNAL OF IMMUNOLOGY

Expansion of circulating counterparts of follicular helper T cells in patients with myasthenia gravis

(2013) Chuanming Luo et al.   JOURNAL OF NEUROIMMUNOLOGY

Systemic Inflammation in Progressive Multiple Sclerosis Involves Follicular T-Helper, Th17- and Activated B-Cells and Correlates with Progression

(2013) Jeppe Romme Christensen et al.   PLoS One

Inhibition of Increased Circulating Tfh Cell by Anti-CD20 Monoclonal Antibody in Patients with Type 1 Diabetes

(2013) Xinyu Xu et al.   PLoS One

Murine thymic selection quantified using a unique method to capture deleted T cells

(2013) G. L. Stritesky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system

(2013) C. Sinclair et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD19+CD24hiCD38hi B Cells Maintain Regulatory T Cells While Limiting TH1 and TH17 Differentiation

(2013) F. Flores-Borja et al.   Science Translational Medicine

IL-10-producing regulatory B cells (B10 cells) in autoimmune disease

(2013) Ioannis Kalampokis et al.   ARTHRITIS RESEARCH & THERAPY

Do MHCII-Presented Neoantigens Drive Type 1 Diabetes and Other Autoimmune Diseases?

(2013) P. Marrack et al.   Cold Spring Harbor Perspectives in Medicine

Humoral Autoimmunity in Type 1 Diabetes: Prediction, Significance, and Detection of Distinct Disease Subtypes

(2013) M. Pietropaolo et al.   Cold Spring Harbor Perspectives in Medicine

Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial

(2013) Stephen E Gitelman et al.   Lancet Diabetes & Endocrinology

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Updated assessment of the prevalence, spectrum and case definition of autoimmune disease

(2012) Scott M. Hayter et al.   AUTOIMMUNITY REVIEWS

Anti-thymocyte globulin (ATG) differentially depletes naïve and memory T cells and permits memory-type regulatory T cells in nonobese diabetic mice

(2012) Chang-Qing Xia et al.   BMC IMMUNOLOGY

Infection as a cause of type 1 diabetes?

(2012) Urs Christen et al.   CURRENT OPINION IN RHEUMATOLOGY

Modulation of Redox Balance Leaves Murine Diabetogenic TH1 T Cells "LAG-3-ing" Behind

(2012) M. M. Delmastro et al.   DIABETES

Following the Fate of One Insulin-Reactive CD4 T cell

(2012) Georgia Fousteri et al.   DIABETES

B-Cell Cross-Presentation of Autologous Antigen Precipitates Diabetes

(2012) E. Marino et al.   DIABETES

Type 1 Diabetes Is Associated With Enterovirus Infection in Gut Mucosa

(2012) M. Oikarinen et al.   DIABETES

Elimination of Germinal-Center-Derived Self-Reactive B Cells Is Governed by the Location and Concentration of Self-Antigen

(2012) Tyani D. Chan et al.   IMMUNITY

Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen

(2012) Justin J. Taylor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Thymic negative selection is functional in NOD mice

(2012) Michael Mingueneau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions

(2012) Ayumi Yoshizaki et al.   NATURE

The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood

(2012) Peter T Sage et al.   NATURE IMMUNOLOGY

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLA-A2 Transgenic NOD/SCID/IL2RG Null Mice

(2012) Wendy W. J. Unger et al.   PLoS One

The Inhibitory Receptor PD-1 Regulates IgA Selection and Bacterial Composition in the Gut

(2012) S. Kawamoto et al.   SCIENCE

Interleukin-10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis

(2012) Natalie A Carter et al.   ARTHRITIS RESEARCH & THERAPY

Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape

(2011) S.-R. Woo et al.   CANCER RESEARCH

Superoxide Production by Macrophages and T Cells Is Critical for the Induction of Autoreactivity and Type 1 Diabetes

(2011) T. C. Thayer et al.   DIABETES

Anti-Islet Autoantibodies Trigger Autoimmune Diabetes in the Presence of an Increased Frequency of Islet-Reactive CD4 T Cells

(2011) D. G. Silva et al.   DIABETES

Age of Islet Autoantibody Appearance and Mean Levels of Insulin, but Not GAD or IA-2 Autoantibodies, Predict Age of Diagnosis of Type 1 Diabetes: Diabetes Autoimmunity Study in the Young

(2011) A. K. Steck et al.   DIABETES CARE

A polymorphism in PTPN2 gene is associated with an earlier onset of type 1 diabetes

(2011) Laura Espino-Paisan et al.   IMMUNOGENETICS

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice

(2011) Taku Okazaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Negative Selection by IgM Superantigen Defines a B Cell Central Tolerance Compartment and Reveals Mutations Allowing Escape

(2011) B. H. Duong et al.   JOURNAL OF IMMUNOLOGY

Arthritogenic Self-Reactive CD4+ T Cells Acquire an FR4hiCD73hi Anergic State in the Presence of Foxp3+ Regulatory T Cells

(2011) R. J. Martinez et al.   JOURNAL OF IMMUNOLOGY

Anti-CD3 Therapy Promotes Tolerance by Selectively Depleting Pathogenic Cells while Preserving Regulatory T Cells

(2011) C. Penaranda et al.   JOURNAL OF IMMUNOLOGY

The Programmed Death-1 Ligand 1:B7-1 Pathway Restrains Diabetogenic Effector T Cells In Vivo

(2011) A. M. Paterson et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Accelerated Autoimmune Diabetes in the Absence of LAG-3

(2011) M. Bettini et al.   JOURNAL OF IMMUNOLOGY

Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status

(2011) Bernice Lo et al.   Journal of Translational Medicine

Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial

(2011) Nicole Sherry et al.   LANCET

Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial

(2011) Tihamer Orban et al.   LANCET

Absence of autoantibodies against glutamate decarboxylase (GAD) in the non-obese diabetic (NOD) mouse and low expression of the enzyme in mouse islets

(2010) L. A. VELLOSO et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Measuring the genetic contribution of a single locus to a multilocus disease

(2010) Jerome I. Rotter et al.   CLINICAL GENETICS

Inflammatory cytokines as a third signal for T cell activation

(2010) Julie M Curtsinger et al.   CURRENT OPINION IN IMMUNOLOGY

Enterovirus Infection and Progression From Islet Autoimmunity to Type 1 Diabetes: The Diabetes and Autoimmunity Study in the Young (DAISY)

(2010) L. C. Stene et al.   DIABETES

Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass

(2010) B. Keymeulen et al.   DIABETOLOGIA

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

(2010) Dimitra Zotos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

(2010) Kim L Good-Jacobson et al.   NATURE IMMUNOLOGY

Chromogranin A is an autoantigen in type 1 diabetes

(2010) Brian D Stadinski et al.   NATURE IMMUNOLOGY

Enteroviruses, type 1 diabetes and hygiene: a complex relationship

(2010) S. Tracy et al.   REVIEWS IN MEDICAL VIROLOGY

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus

(2009) Nicholas Simpson et al.   ARTHRITIS AND RHEUMATISM

The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes

(2009) S. J. Richardson et al.   DIABETOLOGIA

Thymus-specific deletion of insulin induces autoimmune diabetes

(2009) Yong Fan et al.   EMBO JOURNAL

Collagen antibody-induced arthritis in mice: Development of a new arthritogenic 5-clone cocktail of monoclonal anti-type II collagen antibodies

(2009) Pilaiwanwadee Hutamekalin et al.   JOURNAL OF IMMUNOLOGICAL METHODS

New Insights into the Molecular Basis of T Cell Anergy: Anergy Factors, Avoidance Sensors, and Epigenetic Imprinting

(2009) A. D. Wells   JOURNAL OF IMMUNOLOGY

The Development and Function of Regulatory B Cells Expressing IL-10 (B10 Cells) Requires Antigen Receptor Diversity and TLR Signals

(2009) K. Yanaba et al.   JOURNAL OF IMMUNOLOGY

Genetic Evidence That the Differential Expression of the Ligand-Independent Isoform of CTLA-4 Is the Molecular Basis of the Idd5.1 Type 1 Diabetes Region in Nonobese Diabetic Mice

(2009) M. Araki et al.   JOURNAL OF IMMUNOLOGY

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

Cytokine-secreting follicular T cells shape the antibody repertoire

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Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

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(2008) Qizhi Tang et al.   IMMUNITY

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The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells

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(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

Concordance for Islet Autoimmunity among Monozygotic Twins

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CTLA-4 blockade increases IFN -producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients

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Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice

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