标题
Type 1 diabetes pathogenesis and the role of inhibitory receptors in islet tolerance
作者
关键词
-
出版物
Annals of the New York Academy of Sciences
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2019-04-26
DOI
10.1111/nyas.14106
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Self-Reactive B Cells in the Germinal Center Reaction
- (2018) Robert Brink et al. Annual Review of Immunology
- CD4 T Cells Reactive to Hybrid Insulin Peptides are Indicators of Disease Activity in the NOD Mouse
- (2018) Rocky L. Baker et al. DIABETES
- Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors
- (2018) Angeliki M. Stamatouli et al. DIABETES
- A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk
- (2018) Maria J. Redondo et al. DIABETES CARE
- Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA1cin New-Onset Type 1 Diabetes
- (2018) Michael J. Haller et al. DIABETES CARE
- LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells
- (2018) Andreia C. Lino et al. IMMUNITY
- Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function
- (2018) Peter T. Sage et al. JOURNAL OF IMMUNOLOGY
- Thymic tolerance as a key brake on autoimmunity
- (2018) Mickie Cheng et al. NATURE IMMUNOLOGY
- Cancer immunotherapy using checkpoint blockade
- (2018) Antoni Ribas et al. SCIENCE
- Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node
- (2018) Ruby Alonso et al. Nature Communications
- Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes
- (2018) Kevin C. Osum et al. Scientific Reports
- Pathogenic citrulline-multispecific B cell receptor clades in rheumatoid arthritis
- (2018) Philip J Titcombe et al. Arthritis & Rheumatology
- Signal Transducer and Activator of Transcription 3 Hyperactivation Associates With Follicular Helper T Cell Differentiation and Disease Activity in Rheumatoid Arthritis
- (2018) Jun Deng et al. Frontiers in Immunology
- The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future
- (2018) Yi-Guang Chen et al. Frontiers in Endocrinology
- PD-1 Controls Follicular T Helper Cell Positioning and Function
- (2018) Jingwen Shi et al. IMMUNITY
- Interleukin-10 Producing Regulatory B Cells Transformed CD4+CD25− Into Tregs and Enhanced Regulatory T Cells Function in Human Leprosy
- (2018) Mohd. Tarique et al. Frontiers in Immunology
- Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3
- (2018) Jun Wang et al. CELL
- Imbalance of circulating Tfr/Tfh ratio in patients with rheumatoid arthritis
- (2018) Xiuzhen Wang et al. CLINICAL AND EXPERIMENTAL MEDICINE
- LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII
- (2018) Takumi Maruhashi et al. NATURE IMMUNOLOGY
- Treg cells—the next frontier of cell therapy
- (2018) Jeffrey A. Bluestone et al. SCIENCE
- LAG3 (CD223) as a cancer immunotherapy target
- (2017) Lawrence P. Andrews et al. IMMUNOLOGICAL REVIEWS
- An insulin-IAPP hybrid peptide is an endogenous antigen for CD4 T cells in the non-obese diabetic mouse
- (2017) Timothy A. Wiles et al. JOURNAL OF AUTOIMMUNITY
- Human regulatory B cells in health and disease: therapeutic potential
- (2017) Claudia Mauri et al. JOURNAL OF CLINICAL INVESTIGATION
- Ectopic Expression of Self-Antigen Drives Regulatory T Cell Development and Not Deletion of Autoimmune T Cells
- (2017) Thomas Lee et al. JOURNAL OF IMMUNOLOGY
- Relationship between CD4 Regulatory T Cells and Anergy In Vivo
- (2017) Lokesh A. Kalekar et al. JOURNAL OF IMMUNOLOGY
- Type 1 diabetes induction in humanized mice
- (2017) Shulian Tan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition
- (2017) Enfu Hui et al. SCIENCE
- Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent
- (2017) Alice O. Kamphorst et al. SCIENCE
- Directing T cell fate: How thymic antigen presenting cells coordinate thymocyte selection
- (2017) Elise R. Breed et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Regulatory B cells: Phenotype, function and role in transplantation
- (2017) CM Wortel et al. TRANSPLANT IMMUNOLOGY
- CD8+ T cells specific for the islet autoantigen IGRP are restricted in their T cell receptor chain usage
- (2017) Yannick F. Fuchs et al. Scientific Reports
- T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes
- (2017) Adam L. Burrack et al. Frontiers in Endocrinology
- Mechanisms of Regulatory B cell Function in Autoimmune and Inflammatory Diseases beyond IL-10
- (2017) Avijit Ray et al. Journal of Clinical Medicine
- Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes
- (2016) Pia Leete et al. DIABETES
- Circulating CXCR5 + PD-1 + ICOS + Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodies
- (2016) Tyyne Viisanen et al. DIABETES
- Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes
- (2016) Aaron W. Michels et al. DIABETES
- Antithymocyte globulin therapy for patients with recent-onset type 1 diabetes: 2 year results of a randomised trial
- (2016) Stephen E. Gitelman et al. DIABETOLOGIA
- Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage
- (2016) Sven Malchow et al. IMMUNITY
- Thymus-Derived Regulatory T Cells Are Positively Selected on Natural Self-Antigen through Cognate Interactions of High Functional Avidity
- (2016) Elisa Kieback et al. IMMUNITY
- Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis
- (2016) Andrea Schietinger et al. IMMUNITY
- Co-stimulatory and Co-inhibitory Pathways in Autoimmunity
- (2016) Qianxia Zhang et al. IMMUNITY
- Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion
- (2016) Bertram Bengsch et al. IMMUNITY
- Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites
- (2016) Xiaoxiao Wan et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Expanding antigen-specific regulatory networks to treat autoimmunity
- (2016) Xavier Clemente-Casares et al. NATURE
- CD4+ T cell anergy prevents autoimmunity and generates regulatory T cell precursors
- (2016) Lokesh A Kalekar et al. NATURE IMMUNOLOGY
- Tolerance is established in polyclonal CD4+ T cells by distinct mechanisms, according to self-peptide expression patterns
- (2016) Deepali Malhotra et al. NATURE IMMUNOLOGY
- Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes
- (2016) Jenny Aurielle B Babon et al. NATURE MEDICINE
- Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion
- (2016) T. Delong et al. SCIENCE
- The epigenetic landscape of T cell exhaustion
- (2016) D. R. Sen et al. SCIENCE
- Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment
- (2016) Justin A. Spanier et al. Nature Communications
- Characterization of T follicular helper cells in allogeneic normal pregnancy and PDL1 blockage-induced abortion
- (2016) Weihong Zeng et al. Scientific Reports
- Spatiotemporal Dynamics of Insulitis in Human Type 1 Diabetes
- (2016) Kyle C. A. Wedgwood et al. Frontiers in Physiology
- Transcription factors and target genes of pre-TCR signaling
- (2015) Cristina López-Rodríguez et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes
- (2015) Martha Campbell-Thompson et al. DIABETES
- IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients
- (2015) Ricardo C. Ferreira et al. DIABETOLOGIA
- Mouse pancreatic beta cells express MHC class II and stimulate CD4+T cells to proliferate
- (2015) Yuxing Zhao et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Central tolerance spares the private high-avidity CD4+T-cell repertoire specific for an islet antigen in NOD mice
- (2015) Laurent Serre et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The regulatory role of B cells in autoimmunity, infections and cancer: Perspectives beyond IL10 production
- (2015) Melisa Gorosito Serrán et al. FEBS LETTERS
- Antibody Effector Functions Mediated by Fcγ-Receptors Are Compromised during Persistent Viral Infection
- (2015) Andreas Wieland et al. IMMUNITY
- Regulatory B Cells: Origin, Phenotype, and Function
- (2015) Elizabeth C. Rosser et al. IMMUNITY
- Perforin facilitates beta cell killing and regulates autoreactive CD8+ T-cell responses to antigen in mouse models of type 1 diabetes
- (2015) Prerak Trivedi et al. IMMUNOLOGY AND CELL BIOLOGY
- PD-1 Deficiency Enhances Humoral Immunity of Malaria Infection Treatment Vaccine
- (2015) Taiping Liu et al. INFECTION AND IMMUNITY
- Pooled Analysis of Long-Term Survival Data From Phase II and Phase III Trials of Ipilimumab in Unresectable or Metastatic Melanoma
- (2015) Dirk Schadendorf et al. JOURNAL OF CLINICAL ONCOLOGY
- Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity
- (2015) Alison M. Paterson et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Heterogeneity and Lobularity of Pancreatic Pathology in Type 1 Diabetes during the Prediabetic Phase
- (2015) Teresa Rodriguez-Calvo et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Cutting Edge: Identification of Autoreactive CD4+and CD8+T Cell Subsets Resistant to PD-1 Pathway Blockade
- (2015) Kristen E. Pauken et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Nonobese Diabetic Mice Deficient in Chromogranin A Are Protected from Autoimmune Diabetes
- (2015) Rocky L. Baker et al. JOURNAL OF IMMUNOLOGY
- Targeting Anti-Insulin B Cell Receptors Improves Receptor Editing in Type 1 Diabetes–Prone Mice
- (2015) Rachel H. Bonami et al. JOURNAL OF IMMUNOLOGY
- Immunogenetics of type 1 diabetes mellitus
- (2015) Michael P. Morran et al. MOLECULAR ASPECTS OF MEDICINE
- T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection
- (2015) Eoin F. McKinney et al. NATURE
- Type 1 diabetes immunotherapy using polyclonal regulatory T cells
- (2015) Jeffrey A. Bluestone et al. Science Translational Medicine
- PD-1/PD-L1 Costimulatory Pathway-induced Mouse Islet Transplantation Immune Tolerance
- (2015) T. Li et al. TRANSPLANTATION PROCEEDINGS
- Confusing signals: Recent progress in CTLA-4 biology
- (2015) Lucy S.K. Walker et al. TRENDS IN IMMUNOLOGY
- Overcoming T cell exhaustion in infection and cancer
- (2015) Kristen E. Pauken et al. TRENDS IN IMMUNOLOGY
- T follicular regulatory cells in the regulation of B cell responses
- (2015) Peter T. Sage et al. TRENDS IN IMMUNOLOGY
- PD-L1hi B cells are critical regulators of humoral immunity
- (2015) Adnan R. Khan et al. Nature Communications
- Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells
- (2015) T. Kouo et al. Cancer Immunology Research
- LSECtin Expressed on Melanoma Cells Promotes Tumor Progression by Inhibiting Antitumor T-cell Responses
- (2014) F. Xu et al. CANCER RESEARCH
- PD-L1–Driven Tolerance Protects Neurogenin3-Induced Islet Neogenesis to Reverse Established Type 1 Diabetes in NOD Mice
- (2014) Rongying Li et al. DIABETES
- Loss of Anergic B Cells in Prediabetic and New-Onset Type 1 Diabetic Patients
- (2014) Mia J. Smith et al. DIABETES
- Low-Dose Otelixizumab Anti-CD3 Monoclonal Antibody DEFEND-1 Study: Results of the Randomized Phase III Study in Recent-Onset Human Type 1 Diabetes
- (2014) Ronnie Aronson et al. DIABETES CARE
- PD-L1 gene polymorphisms and low serum level of PD-L1 protein are associated to type 1 diabetes in Chile
- (2014) Carolina Pizarro et al. DIABETES-METABOLISM RESEARCH AND REVIEWS
- Both retention and recirculation contribute to long-lived regulatory T-cell accumulation in the thymus
- (2014) EnJun Yang et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Molecular and Transcriptional Basis of CD4+ T Cell Dysfunction during Chronic Infection
- (2014) Alison Crawford et al. IMMUNITY
- T Follicular Helper Cell Differentiation, Function, and Roles in Disease
- (2014) Shane Crotty IMMUNITY
- Functional cytotoxic T lymphocytes against IGRP206-214 predict diabetes in the non-obese diabetic mouse
- (2014) Hyun-Ja Ko et al. IMMUNOLOGY AND CELL BIOLOGY
- Islet inflammation in human type 1 diabetes mellitus
- (2014) Noel G. Morgan et al. IUBMB LIFE
- Prevalence of Type 1 and Type 2 Diabetes Among Children and Adolescents From 2001 to 2009
- (2014) Dana Dabelea et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Follicular helper T cell signature in type 1 diabetes
- (2014) Rupert Kenefeck et al. JOURNAL OF CLINICAL INVESTIGATION
- Prolonged antigen presentation by immune complex–binding dendritic cells programs the proliferative capacity of memory CD8 T cells
- (2014) Beatriz León et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Through Regulation of TCR Expression Levels, an Idd7 Region Gene(s) Interactively Contributes to the Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in Nonobese Diabetic Mice
- (2014) D. V. Serreze et al. JOURNAL OF IMMUNOLOGY
- TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity
- (2014) V. Lampropoulou et al. JOURNAL OF IMMUNOLOGY
- Reduced Regulatory T Cell Diversity in NOD Mice Is Linked to Early Events in the Thymus
- (2014) C. Ferreira et al. JOURNAL OF IMMUNOLOGY
- TCR Affinity and Tolerance Mechanisms Converge To Shape T Cell Diabetogenic Potential
- (2014) Maria Bettini et al. JOURNAL OF IMMUNOLOGY
- IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases
- (2014) Ping Shen et al. NATURE
- Protein kinase C-η controls CTLA-4–mediated regulatory T cell function
- (2014) Kok-Fai Kong et al. NATURE IMMUNOLOGY
- Lymphocyte Activation Gene-3 (LAG-3) Negatively Regulates Environmentally-Induced Autoimmunity
- (2014) Vibha Jha et al. PLoS One
- Lymphocyte Activation Gene 3 (LAG-3) Modulates the Ability of CD4 T-cells to Be Suppressed In Vivo
- (2014) Nicholas M. Durham et al. PLoS One
- Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes
- (2014) L. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement
- (2014) Chun Jing Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity
- (2014) Z. Sabouri et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Detection of self-reactive CD8+T cells with an anergic phenotype in healthy individuals
- (2014) Yuka Maeda et al. SCIENCE
- Genetic deletion of granzyme B does not confer resistance to the development of spontaneous diabetes in non-obese diabetic mice
- (2013) M. Kobayashi et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- PD-1, but Not PD-L1, Expressed by Islet-Reactive CD4 + T Cells Suppresses Infiltration of the Pancreas During Type 1 Diabetes
- (2013) Kristen E. Pauken et al. DIABETES
- Teplizumab (Anti-CD3 mAb) Treatment Preserves C-Peptide Responses in Patients With New-Onset Type 1 Diabetes in a Randomized Controlled Trial: Metabolic and Immunologic Features at Baseline Identify a Subgroup of Responders
- (2013) K. C. Herold et al. DIABETES
- Teplizumab Preserves C-Peptide in Recent-Onset Type 1 Diabetes: Two-Year Results From the Randomized, Placebo-Controlled Protege Trial
- (2013) W. Hagopian et al. DIABETES
- Costimulation Modulation With Abatacept in Patients With Recent-Onset Type 1 Diabetes: Follow-up 1 Year After Cessation of Treatment
- (2013) Tihamer Orban et al. DIABETES CARE
- Efficacy and safety of low-dose otelixizumab anti-CD3 monoclonal antibody in preserving C-peptide secretion in adolescent type 1 diabetes: DEFEND-2, a randomized, placebo-controlled, double-blind, multi-centre study
- (2013) P. Ambery et al. DIABETIC MEDICINE
- The Prevalence of Type 1 Diabetes in the United States
- (2013) Andy Menke et al. EPIDEMIOLOGY
- Extrathymic Aire-Expressing Cells Are a Distinct Bone Marrow-Derived Population that Induce Functional Inactivation of CD4+ T Cells
- (2013) James M. Gardner et al. IMMUNITY
- Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma
- (2013) Tyler R. Simpson et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The B7-Independent Isoform of CTLA-4 Functions To Regulate Autoimmune Diabetes
- (2013) M. Stumpf et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Type 1 Diabetes Occurs despite Robust Anergy among Endogenous Insulin-Specific CD4 T Cells in NOD Mice
- (2013) K. E. Pauken et al. JOURNAL OF IMMUNOLOGY
- B Lymphocyte "Original Sin" in the Bone Marrow Enhances Islet Autoreactivity in Type 1 Diabetes-Prone Nonobese Diabetic Mice
- (2013) R. A. Henry-Bonami et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: CD4 T Cells Reactive to an Islet Amyloid Polypeptide Peptide Accumulate in the Pancreas and Contribute to Disease Pathogenesis in Nonobese Diabetic Mice
- (2013) R. L. Baker et al. JOURNAL OF IMMUNOLOGY
- Expansion of circulating counterparts of follicular helper T cells in patients with myasthenia gravis
- (2013) Chuanming Luo et al. JOURNAL OF NEUROIMMUNOLOGY
- Systemic Inflammation in Progressive Multiple Sclerosis Involves Follicular T-Helper, Th17- and Activated B-Cells and Correlates with Progression
- (2013) Jeppe Romme Christensen et al. PLoS One
- Inhibition of Increased Circulating Tfh Cell by Anti-CD20 Monoclonal Antibody in Patients with Type 1 Diabetes
- (2013) Xinyu Xu et al. PLoS One
- Murine thymic selection quantified using a unique method to capture deleted T cells
- (2013) G. L. Stritesky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system
- (2013) C. Sinclair et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CD19+CD24hiCD38hi B Cells Maintain Regulatory T Cells While Limiting TH1 and TH17 Differentiation
- (2013) F. Flores-Borja et al. Science Translational Medicine
- IL-10-producing regulatory B cells (B10 cells) in autoimmune disease
- (2013) Ioannis Kalampokis et al. ARTHRITIS RESEARCH & THERAPY
- Do MHCII-Presented Neoantigens Drive Type 1 Diabetes and Other Autoimmune Diseases?
- (2013) P. Marrack et al. Cold Spring Harbor Perspectives in Medicine
- Humoral Autoimmunity in Type 1 Diabetes: Prediction, Significance, and Detection of Distinct Disease Subtypes
- (2013) M. Pietropaolo et al. Cold Spring Harbor Perspectives in Medicine
- Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial
- (2013) Stephen E Gitelman et al. Lancet Diabetes & Endocrinology
- Germinal Centers
- (2012) Gabriel D. Victora et al. Annual Review of Immunology
- Updated assessment of the prevalence, spectrum and case definition of autoimmune disease
- (2012) Scott M. Hayter et al. AUTOIMMUNITY REVIEWS
- Anti-thymocyte globulin (ATG) differentially depletes naïve and memory T cells and permits memory-type regulatory T cells in nonobese diabetic mice
- (2012) Chang-Qing Xia et al. BMC IMMUNOLOGY
- Infection as a cause of type 1 diabetes?
- (2012) Urs Christen et al. CURRENT OPINION IN RHEUMATOLOGY
- Modulation of Redox Balance Leaves Murine Diabetogenic TH1 T Cells "LAG-3-ing" Behind
- (2012) M. M. Delmastro et al. DIABETES
- Following the Fate of One Insulin-Reactive CD4 T cell
- (2012) Georgia Fousteri et al. DIABETES
- B-Cell Cross-Presentation of Autologous Antigen Precipitates Diabetes
- (2012) E. Marino et al. DIABETES
- Type 1 Diabetes Is Associated With Enterovirus Infection in Gut Mucosa
- (2012) M. Oikarinen et al. DIABETES
- Elimination of Germinal-Center-Derived Self-Reactive B Cells Is Governed by the Location and Concentration of Self-Antigen
- (2012) Tyani D. Chan et al. IMMUNITY
- Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen
- (2012) Justin J. Taylor et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Thymic negative selection is functional in NOD mice
- (2012) Michael Mingueneau et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
- (2012) Ken T. Coppieters et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions
- (2012) Ayumi Yoshizaki et al. NATURE
- The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood
- (2012) Peter T Sage et al. NATURE IMMUNOLOGY
- Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
- (2012) Suzanne L. Topalian et al. NEW ENGLAND JOURNAL OF MEDICINE
- Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLA-A2 Transgenic NOD/SCID/IL2RG Null Mice
- (2012) Wendy W. J. Unger et al. PLoS One
- The Inhibitory Receptor PD-1 Regulates IgA Selection and Bacterial Composition in the Gut
- (2012) S. Kawamoto et al. SCIENCE
- Interleukin-10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis
- (2012) Natalie A Carter et al. ARTHRITIS RESEARCH & THERAPY
- Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape
- (2011) S.-R. Woo et al. CANCER RESEARCH
- Superoxide Production by Macrophages and T Cells Is Critical for the Induction of Autoreactivity and Type 1 Diabetes
- (2011) T. C. Thayer et al. DIABETES
- Anti-Islet Autoantibodies Trigger Autoimmune Diabetes in the Presence of an Increased Frequency of Islet-Reactive CD4 T Cells
- (2011) D. G. Silva et al. DIABETES
- Age of Islet Autoantibody Appearance and Mean Levels of Insulin, but Not GAD or IA-2 Autoantibodies, Predict Age of Diagnosis of Type 1 Diabetes: Diabetes Autoimmunity Study in the Young
- (2011) A. K. Steck et al. DIABETES CARE
- A polymorphism in PTPN2 gene is associated with an earlier onset of type 1 diabetes
- (2011) Laura Espino-Paisan et al. IMMUNOGENETICS
- T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse
- (2011) Amy E. Moran et al. JOURNAL OF EXPERIMENTAL MEDICINE
- PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice
- (2011) Taku Okazaki et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Negative Selection by IgM Superantigen Defines a B Cell Central Tolerance Compartment and Reveals Mutations Allowing Escape
- (2011) B. H. Duong et al. JOURNAL OF IMMUNOLOGY
- Arthritogenic Self-Reactive CD4+ T Cells Acquire an FR4hiCD73hi Anergic State in the Presence of Foxp3+ Regulatory T Cells
- (2011) R. J. Martinez et al. JOURNAL OF IMMUNOLOGY
- Anti-CD3 Therapy Promotes Tolerance by Selectively Depleting Pathogenic Cells while Preserving Regulatory T Cells
- (2011) C. Penaranda et al. JOURNAL OF IMMUNOLOGY
- The Programmed Death-1 Ligand 1:B7-1 Pathway Restrains Diabetogenic Effector T Cells In Vivo
- (2011) A. M. Paterson et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Accelerated Autoimmune Diabetes in the Absence of LAG-3
- (2011) M. Bettini et al. JOURNAL OF IMMUNOLOGY
- Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status
- (2011) Bernice Lo et al. Journal of Translational Medicine
- Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial
- (2011) Nicole Sherry et al. LANCET
- Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial
- (2011) Tihamer Orban et al. LANCET
- Absence of autoantibodies against glutamate decarboxylase (GAD) in the non-obese diabetic (NOD) mouse and low expression of the enzyme in mouse islets
- (2010) L. A. VELLOSO et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Measuring the genetic contribution of a single locus to a multilocus disease
- (2010) Jerome I. Rotter et al. CLINICAL GENETICS
- Inflammatory cytokines as a third signal for T cell activation
- (2010) Julie M Curtsinger et al. CURRENT OPINION IN IMMUNOLOGY
- Enterovirus Infection and Progression From Islet Autoimmunity to Type 1 Diabetes: The Diabetes and Autoimmunity Study in the Young (DAISY)
- (2010) L. C. Stene et al. DIABETES
- Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass
- (2010) B. Keymeulen et al. DIABETOLOGIA
- IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism
- (2010) Dimitra Zotos et al. JOURNAL OF EXPERIMENTAL MEDICINE
- PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells
- (2010) Kim L Good-Jacobson et al. NATURE IMMUNOLOGY
- Chromogranin A is an autoantigen in type 1 diabetes
- (2010) Brian D Stadinski et al. NATURE IMMUNOLOGY
- Enteroviruses, type 1 diabetes and hygiene: a complex relationship
- (2010) S. Tracy et al. REVIEWS IN MEDICAL VIROLOGY
- Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus
- (2009) Nicholas Simpson et al. ARTHRITIS AND RHEUMATISM
- The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes
- (2009) S. J. Richardson et al. DIABETOLOGIA
- Thymus-specific deletion of insulin induces autoimmune diabetes
- (2009) Yong Fan et al. EMBO JOURNAL
- Collagen antibody-induced arthritis in mice: Development of a new arthritogenic 5-clone cocktail of monoclonal anti-type II collagen antibodies
- (2009) Pilaiwanwadee Hutamekalin et al. JOURNAL OF IMMUNOLOGICAL METHODS
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- (2009) A. D. Wells JOURNAL OF IMMUNOLOGY
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- (2009) K. Yanaba et al. JOURNAL OF IMMUNOLOGY
- Genetic Evidence That the Differential Expression of the Ligand-Independent Isoform of CTLA-4 Is the Molecular Basis of the Idd5.1 Type 1 Diabetes Region in Nonobese Diabetic Mice
- (2009) M. Araki et al. JOURNAL OF IMMUNOLOGY
- Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
- (2009) Jeffrey C Barrett et al. NATURE GENETICS
- Cytokine-secreting follicular T cells shape the antibody repertoire
- (2009) R Lee Reinhardt et al. NATURE IMMUNOLOGY
- Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal
- (2009) Brian T Fife et al. NATURE IMMUNOLOGY
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- (2009) Moutih Rafei et al. NATURE MEDICINE
- Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function
- (2009) Mark D. Pescovitz et al. NEW ENGLAND JOURNAL OF MEDICINE
- Non-obese diabetic mice select a low-diversity repertoire of natural regulatory T cells
- (2009) C. Ferreira et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes
- (2008) Pierre Pirot et al. Arquivos Brasileiros de Endocrinologia e Metabologia
- Regulatory T Cells and Immune Tolerance
- (2008) Shimon Sakaguchi et al. CELL
- HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk: Analysis of the Type 1 Diabetes Genetics Consortium Families
- (2008) H. Erlich et al. DIABETES
- Analysis of pancreas tissue in a child positive for islet cell antibodies
- (2008) M. Oikarinen et al. DIABETOLOGIA
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- (2008) Qizhi Tang et al. IMMUNITY
- CD40 on NOD CD4 T cells contributes to their activation and pathogenicity
- (2008) Rocky L. Baker et al. JOURNAL OF AUTOIMMUNITY
- RS rearrangement frequency as a marker of receptor editing in lupus and type 1 diabetes
- (2008) Anil K. Panigrahi et al. JOURNAL OF EXPERIMENTAL MEDICINE
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- (2008) Sokol Haxhinasto et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
- (2008) Shawn D Blackburn et al. NATURE IMMUNOLOGY
- Concordance for Islet Autoimmunity among Monozygotic Twins
- (2008) Maria J. Redondo et al. NEW ENGLAND JOURNAL OF MEDICINE
- The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors
- (2008) A. M. D'Alise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CTLA-4 blockade increases IFN -producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients
- (2008) C. I. Liakou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differentiation of regulatory Foxp3+ T cells in the thymic cortex
- (2008) A. Liston et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Deletional Tolerance Mediated by Extrathymic Aire-Expressing Cells
- (2008) J. M. Gardner et al. SCIENCE
- CTLA-4 Control over Foxp3+ Regulatory T Cell Function
- (2008) K. Wing et al. SCIENCE
- Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice
- (2007) Mohammed Javeed I. Ansari et al. CLINICAL IMMUNOLOGY
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