The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future

Autoreactive T cells in type 1 diabetes

(2017) Alberto Pugliese   JOURNAL OF CLINICAL INVESTIGATION

Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes

(2017) Jeremy J. Ratiu et al.   JOURNAL OF IMMUNOLOGY

CD137 Plays Both Pathogenic and Protective Roles in Type 1 Diabetes Development in NOD Mice

(2017) Matthew H. Forsberg et al.   JOURNAL OF IMMUNOLOGY

Haematopoietic stem and progenitor cells from human pluripotent stem cells

(2017) Ryohichi Sugimura et al.   NATURE

Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity

(2017) David Zemmour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type 1 diabetes mellitus

(2017) Anastasia Katsarou et al.   Nature Reviews Disease Primers

Isogenic Cellular Systems Model the Impact of Genetic Risk Variants in the Pathogenesis of Type 1 Diabetes

(2017) Mark A. Wallet et al.   Frontiers in Endocrinology

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans

(2016) Tommi Vatanen et al.   CELL

Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes

(2016) Michael J. Haller et al.   DIABETES

CRISPR-Cas9–Mediated Modification of the NOD Mouse Genome With Ptpn22 R619W Mutation Increases Autoimmune Diabetes

(2016) Xiaotian Lin et al.   DIABETES

An Increased Diagnostic Sensitivity of Truncated GAD65 Autoantibodies in Type 1 Diabetes May Be Related to HLA-DQ8

(2016) Axel Wester et al.   DIABETES

The autoimmunity-associated gene RGS1 affects the frequency of T follicular helper cells

(2016) C Caballero-Franco et al.   GENES AND IMMUNITY

Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice

(2016) Bixuan Lin et al.   IMMUNOGENETICS

Ptpn22Modifies Regulatory T Cell Homeostasis via GITR Upregulation

(2016) Dominika J. Nowakowska et al.   JOURNAL OF IMMUNOLOGY

Generation of stem cell-derived β-cells from patients with type 1 diabetes

(2016) Jeffrey R. Millman et al.   Nature Communications

The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes

(2015) Aleksandar D. Kostic et al.   Cell Host & Microbe

Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes

(2015) Clayton E. Mathews et al.   DIABETES

Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes

(2015) Song Xue et al.   DIABETES

A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice

(2015) Ronald G. Gill et al.   DIABETES

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

(2015) Martha Campbell-Thompson et al.   DIABETES

Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes

(2015) Aimon K. Alkanani et al.   DIABETES

Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease

(2015) Wenning Qin et al.   GENETICS

The Autoimmunity-Associated Gene CLEC16A Modulates Thymic Epithelial Cell Autophagy and Alters T Cell Selection

(2015) Cornelia Schuster et al.   IMMUNITY

Ptpn22andCd2Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice

(2015) Heather I. Fraser et al.   JOURNAL OF IMMUNOLOGY

Maternal Antibiotic Treatment Protects Offspring from Diabetes Development in Nonobese Diabetic Mice by Generation of Tolerogenic APCs

(2015) Youjia Hu et al.   JOURNAL OF IMMUNOLOGY

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

(2015) Suna Onengut-Gumuscu et al.   NATURE GENETICS

Thinking bedside at the bench: the NOD mouse model of T1DM

(2015) James C. Reed et al.   Nature Reviews Endocrinology

Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease

(2015) Wenning Qin et al.   GENETICS

Antibiotics in Early Life Alter the Gut Microbiome and Increase Disease Incidence in a Spontaneous Mouse Model of Autoimmune Insulin-Dependent Diabetes

(2015) Sophie Candon et al.   PLoS One

Compromised Gut Microbiota Networks in Children With Anti-Islet Cell Autoimmunity

(2014) David Endesfelder et al.   DIABETES

A Humanized Mouse Model of Autoimmune Insulitis

(2014) Ashley A. Viehmann Milam et al.   DIABETES

A CRISPR view of development

(2014) Melissa M. Harrison et al.   GENES & DEVELOPMENT

Congenic mice reveal genetic epistasis and overlapping disease loci for autoimmune diabetes and listeriosis

(2014) Nancy Wang et al.   IMMUNOGENETICS

Long term effect of gut microbiota transfer on diabetes development

(2014) Jian Peng et al.   JOURNAL OF AUTOIMMUNITY

Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes

(2014) Michael J. Haller et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced Early Expansion and Maturation of Semi-Invariant NK T Cells Inhibited Autoimmune Pathogenesis in Congenic Nonobese Diabetic Mice

(2014) A. Ueno et al.   JOURNAL OF IMMUNOLOGY

Tyrosine Phosphatase PTPN22: Multifunctional Regulator of Immune Signaling, Development, and Disease

(2013) Nunzio Bottini et al.   Annual Review of Immunology

Gene Targeting in NOD Mouse Embryos Using Zinc-Finger Nucleases

(2013) Y.-G. Chen et al.   DIABETES

Gender Bias in Autoimmunity Is Influenced by Microbiota

(2013) Leonid Yurkovetskiy et al.   IMMUNITY

Genetic Interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 Protective Loci in the Nonobese Diabetic Mouse Model of Type 1 Diabetes

(2013) X. Lin et al.   JOURNAL OF IMMUNOLOGY

Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity

(2013) Emma E. Hamilton-Williams et al.   MAMMALIAN GENOME

The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings

(2013) Alberto Pugliese et al.   PEDIATRIC DIABETES

Testing Agents for Prevention or Reversal of Type 1 Diabetes in Rodents

(2013) Christian W. Grant et al.   PLoS One

Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity

(2013) J. G. M. Markle et al.   SCIENCE

PTPN22 Silencing in the NOD Model Indicates the Type 1 Diabetes-Associated Allele Is Not a Loss-of-Function Variant

(2012) P. Zheng et al.   DIABETES

Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs  -Cell Function

(2012) S. A. Long et al.   DIABETES

Evidence of Gene-Gene Interaction and Age-at-Diagnosis Effects in Type 1 Diabetes

(2012) J. M. M. Howson et al.   DIABETES

Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse

(2012) C. H. F. Hansen et al.   DIABETOLOGIA

A strategy for combining minor genetic susceptibility genes to improve prediction of disease in type 1 diabetes

(2012) C Winkler et al.   GENES AND IMMUNITY

The B10 Idd9.3 Locus Mediates Accumulation of Functionally Superior CD137+ Regulatory T Cells in the Nonobese Diabetic Type 1 Diabetes Model

(2012) K. Kachapati et al.   JOURNAL OF IMMUNOLOGY

Beyond HLA-A*0201: New HLA-Transgenic Nonobese Diabetic Mouse Models of Type 1 Diabetes Identify the Insulin C-Peptide as a Rich Source of CD8+ T Cell Epitopes

(2012) Z. Antal et al.   JOURNAL OF IMMUNOLOGY

Subcongenic Analyses Reveal Complex Interactions between Distal Chromosome 4 Genes Controlling Diabetogenic B Cells and CD4 T Cells in Nonobese Diabetic Mice

(2012) J. Stolp et al.   JOURNAL OF IMMUNOLOGY

Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLA-A2 Transgenic NOD/SCID/IL2RG Null Mice

(2012) Wendy W. J. Unger et al.   PLoS One

Prevention of "Humanized" Diabetogenic CD8 T-Cell Responses in HLA-Transgenic NOD Mice by a Multipeptide Coupled-Cell Approach

(2011) M. Niens et al.   DIABETES

HLA-A2-Matched Peripheral Blood Mononuclear Cells From Type 1 Diabetic Patients, but Not Nondiabetic Donors, Transfer Insulitis to NOD-scid/ cnull/HLA-A2 Transgenic Mice Concurrent With the Expansion of Islet-Specific CD8+ T cells

(2011) F. Whitfield-Larry et al.   DIABETES

Tests for Genetic Interactions in Type 1 Diabetes

(2011) Grant Morahan et al.   DIABETES

The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function

(2011) K. D. Gerold et al.   DIABETES

IL-17 Silencing Does Not Protect Nonobese Diabetic Mice from Autoimmune Diabetes

(2011) J. Joseph et al.   JOURNAL OF IMMUNOLOGY

Evaluating Preclinical Efficacy

(2011) M. A. Atkinson   Science Translational Medicine

Zinc-finger nucleases: new strategies to target the rat genome

(2010) Aron M. Geurts et al.   CLINICAL SCIENCE

Idd9.2 and Idd9.3 Protective Alleles Function in CD4+ T-Cells and Nonlymphoid Cells to Prevent Expansion of Pathogenic Islet-Specific CD8+ T-Cells

(2010) E. E. Hamilton-Williams et al.   DIABETES

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

(2010) Yenkel Grinberg-Bleyer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nonobese Diabetic Congenic Strain Analysis of Autoimmune Diabetes Reveals Genetic Complexity of the Idd18 Locus and Identifies Vav3 as a Candidate Gene

(2010) H. I. Fraser et al.   JOURNAL OF IMMUNOLOGY

Targeted integration in rat and mouse embryos with zinc-finger nucleases

(2010) Xiaoxia Cui et al.   NATURE BIOTECHNOLOGY

Genome editing with engineered zinc finger nucleases

(2010) Fyodor D. Urnov et al.   NATURE REVIEWS GENETICS

Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease

(2010) John P. Driver et al.   Seminars in Immunopathology

Gene targeting in the rat: advances and opportunities

(2010) Howard J. Jacob et al.   TRENDS IN GENETICS

siRNA vs. shRNA: Similarities and differences

(2009) Donald D. Rao et al.   ADVANCED DRUG DELIVERY REVIEWS

Idd9.1 Locus Controls the Suppressive Activity of FoxP3+CD4+CD25+ Regulatory T-Cells

(2009) J. Yamanouchi et al.   DIABETES

Genetic Evidence That the Differential Expression of the Ligand-Independent Isoform of CTLA-4 Is the Molecular Basis of the Idd5.1 Type 1 Diabetes Region in Nonobese Diabetic Mice

(2009) M. Araki et al.   JOURNAL OF IMMUNOLOGY

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus

(2009) H. M. McGuire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases

(2009) Aron M. Geurts et al.   SCIENCE

Idd9/11 Genetic Locus Regulates Diabetogenic Activity of CD4 T-Cells in Nonobese Diabetic (NOD) Mice

(2008) Y.-G. Chen et al.   DIABETES

PTPN22 Trp620 Explains the Association of Chromosome 1p13 With Type 1 Diabetes and Shows a Statistical Interaction With HLA Class II Genotypes

(2008) D. J. Smyth et al.   DIABETES

Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial

(2008) Kirsti Näntö-Salonen et al.   LANCET

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

(2008) Li Wen et al.   NATURE