PD-L1–Driven Tolerance Protects Neurogenin3-Induced Islet Neogenesis to Reverse Established Type 1 Diabetes in NOD Mice

PD-1, but Not PD-L1, Expressed by Islet-Reactive CD4 + T Cells Suppresses Infiltration of the Pancreas During Type 1 Diabetes

(2013) Kristen E. Pauken et al.   DIABETES

Anti-TCRβ mAb Induces Long-Term Allograft Survival by Reducing Antigen-Reactive T Cells and Sparing Regulatory T Cells

(2012) Y. Miyahara et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleukin-1 Blockade: Evidence of Improved Immune Regulation

(2011) V. Ablamunits et al.   DIABETES

The Programmed Death-1 Ligand 1:B7-1 Pathway Restrains Diabetogenic Effector T Cells In Vivo

(2011) A. M. Paterson et al.   JOURNAL OF IMMUNOLOGY

Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells

(2011) Jeongkyung Lee et al.   Islets

β-Cells Step Up in Controlling the Autoimmune Response

(2010) Paolo Fiorina   DIABETES

A Novel Clinically Relevant Strategy to Abrogate Autoimmunity and Regulate Alloimmunity in NOD Mice

(2010) A. Vergani et al.   DIABETES

Deficiency in B7-H1 (PD-L1)/PD-1 Coinhibition Triggers Pancreatic β-Cell Destruction by Insulin-Specific, Murine CD8 T-Cells

(2010) Tarvo Rajasalu et al.   DIABETES

Islet Transplantation a Decade Later and Strategies for Filling a Half-Full Glass

(2010) R. P. Robertson   DIABETES

Transgenic expression of haem oxygenase-1 in pancreatic beta cells protects non-obese mice used as a model of diabetes from autoimmune destruction and prolongs graft survival following islet transplantation

(2010) S. H. Huang et al.   DIABETOLOGIA

The PD-1 pathway in tolerance and autoimmunity

(2010) Loise M. Francisco et al.   IMMUNOLOGICAL REVIEWS

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

(2010) Yenkel Grinberg-Bleyer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neurogenin3 Is Sufficient for Transdetermination of Hepatic Progenitor Cells into Neo-Islets In Vivo but Not Transdifferentiation of Hepatocytes

(2009) Vijay Yechoor et al.   DEVELOPMENTAL CELL

Immune Depletion With Cellular Mobilization Imparts Immunoregulation and Reverses Autoimmune Diabetes in Nonobese Diabetic Mice

(2009) M. J. Parker et al.   DIABETES

Gene Therapy with Neurogenin 3 and Betacellulin Reverses Major Metabolic Problems in Insulin-Deficient Diabetic Mice

(2009) Vijay Yechoor et al.   ENDOCRINOLOGY

PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+CD25Hi regulatory T cells

(2009) Wenshi Wang et al.   INTERNATIONAL IMMUNOLOGY

Immune tolerance: What is unique about the liver

(2009) Gisa Tiegs et al.   JOURNAL OF AUTOIMMUNITY

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transgenic Expression of Single-Chain Anti-CTLA-4 Fv on   Cells Protects Nonobese Diabetic Mice from Autoimmune Diabetes

(2009) S.-J. Shieh et al.   JOURNAL OF IMMUNOLOGY

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

(2009) Brian T Fife et al.   NATURE IMMUNOLOGY

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

Protective Role of Programmed Death 1 Ligand 1 (PD-L1)in Nonobese Diabetic Mice: The Paradox in Transgenic Models

(2008) C.-J. Wang et al.   DIABETES

Surface markers for the murine oval cell response

(2008) Craig Dorrell et al.   HEPATOLOGY

Interaction of human PD-L1 and B7-1

(2008) Manish J. Butte et al.   MOLECULAR IMMUNOLOGY

Transplantation of NIT-1 Cells Expressing pD-L1 for Treatment of Streptozotocin-Induced Diabetes

(2008) Xue Wen et al.   TRANSPLANTATION