Journal
JOURNAL OF CLINICAL MEDICINE
Volume 6, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/jcm6010012
Keywords
B cell; immune regulation; autoimmunity; inflammation
Categories
Funding
- National Institutes of Health [R01 AI069358, 1R56AI122655]
- National Multiple Sclerosis Society [RG 1501-03034]
- Blood Center Research Foundation
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R56AI122655, R56AI129348] Funding Source: NIH RePORTER
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In the past two decades it has become clear that in addition to antigen presentation and antibody production B cells play prominent roles in immune regulation. While B cell-derived IL-10 has garnered much attention, B cells also effectively regulate inflammation by a variety of IL-10-independent mechanisms. B cell regulation has been studied in both autoimmune and inflammatory diseases. While collectively called regulatory B cells (Breg), no definitive phenotype has emerged for B cells with regulatory potential. This has made their study challenging and thus unique B cell regulatory mechanisms have emerged in a disease-dependent manner. Thus to harness the therapeutic potential of Breg, further studies are needed to understand how they emerge and are induced to evoke their regulatory activities.
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