Rapid and improved characterization of therapeutic antibodies and antibody related products using IdeS digestion and subunit analysis
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Rapid and improved characterization of therapeutic antibodies and antibody related products using IdeS digestion and subunit analysis
Authors
Keywords
-
Journal
ANALYST
Volume 141, Issue 11, Pages 3114-3125
Publisher
Royal Society of Chemistry (RSC)
Online
2016-05-04
DOI
10.1039/c6an00071a
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Characterization of cetuximab Fc/2 dimers by off-line CZE-MS
- (2016) Yannis-Nicolas François et al. ANALYTICA CHIMICA ACTA
- Structural characterization of antibody drug conjugate by a combination of intact, middle-up and bottom-up techniques using sheathless capillary electrophoresis – Tandem mass spectrometry as nanoESI infusion platform and separation method
- (2016) Nassur Said et al. ANALYTICA CHIMICA ACTA
- Glycation of polyclonal IgGs: Effect of sugar excipients during stability studies
- (2016) Y. Leblanc et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Cutting-edge mass spectrometry methods for the multi-level structural characterization of antibody-drug conjugates
- (2016) Alain Beck et al. Expert Review of Proteomics
- Comprehensive glycosylation profiling of IgG and IgG-fusion proteins by top-down MS with multiple fragmentation techniques
- (2016) Bao Quoc Tran et al. Journal of Proteomics
- Characterization of mAb dimers reveals predominant dimer forms common in therapeutic mAbs
- (2016) Friederike Plath et al. mAbs
- Full validation of therapeutic antibody sequences by middle-up mass measurements and middle-down protein sequencing
- (2016) Anja Resemann et al. mAbs
- A rapid approach for characterization of thiol-conjugated antibody–drug conjugates and calculation of drug–antibody ratio by liquid chromatography mass spectrometry
- (2015) David Firth et al. ANALYTICAL BIOCHEMISTRY
- Characterization of the Acidic Species of a Monoclonal Antibody Using Weak Cation Exchange Chromatography and LC-MS
- (2015) Gomathinayagam Ponniah et al. ANALYTICAL CHEMISTRY
- Glycoform Separation and Characterization of Cetuximab Variants by Middle-up Off-Line Capillary Zone Electrophoresis-UV/Electrospray Ionization-MS
- (2015) Michael Biacchi et al. ANALYTICAL CHEMISTRY
- Characterization of the N-Terminal Heterogeneities of Monoclonal Antibodies Using In-Gel Charge Derivatization of α-Amines and LC-MS/MS
- (2015) Daniel Ayoub et al. ANALYTICAL CHEMISTRY
- Direct Identification of Rituximab Main Isoforms and Subunit Analysis by Online Selective Comprehensive Two-Dimensional Liquid Chromatography–Mass Spectrometry
- (2015) Dwight R. Stoll et al. ANALYTICAL CHEMISTRY
- Chromatographic, Electrophoretic, and Mass Spectrometric Methods for the Analytical Characterization of Protein Biopharmaceuticals
- (2015) Szabolcs Fekete et al. ANALYTICAL CHEMISTRY
- Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis
- (2015) Yoann Rombouts et al. ANNALS OF THE RHEUMATIC DISEASES
- Real-time product attribute control to manufacture antibodies with defined N-linked glycan levels
- (2015) Craig Zupke et al. BIOTECHNOLOGY PROGRESS
- EndoS and EndoS2 hydrolyze Fc-glycans on therapeutic antibodies with different glycoform selectivity and can be used for rapid quantification of high-mannose glycans
- (2015) Jonathan Sjögren et al. GLYCOBIOLOGY
- Characterization of antibody drug conjugate positional isomers at cysteine residues by peptide mapping LC–MS analysis
- (2015) Marie-Claire Janin-Bussat et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Recommendations for the evaluation of specimen stability for flow cytometric testing during drug development
- (2015) Lynette Brown et al. JOURNAL OF IMMUNOLOGICAL METHODS
- A method for high-throughput, sensitive analysis of IgG Fc and Fab glycosylation by capillary electrophoresis
- (2015) Alison E. Mahan et al. JOURNAL OF IMMUNOLOGICAL METHODS
- The Bacterial Enzyme IdeS Cleaves the IgG-Type of B Cell Receptor (BCR), Abolishes BCR-Mediated Cell Signaling, and Inhibits Memory B Cell Activation
- (2015) Sofia Järnum et al. JOURNAL OF IMMUNOLOGY
- Cutting-edge mass spectrometry characterization of originator, biosimilar and biobetter antibodies
- (2015) Alain Beck et al. JOURNAL OF MASS SPECTROMETRY
- Investigation of antibody disulfide reduction and re-oxidation and impact to biological activities
- (2015) Tian Wang et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Pan-ebolavirus and Pan-filovirus Mouse Monoclonal Antibodies: Protection against Ebola and Sudan Viruses
- (2015) Frederick W. Holtsberg et al. JOURNAL OF VIROLOGY
- Production of α2,6-sialylated IgG1 in CHO cells
- (2015) Céline Raymond et al. mAbs
- A chemical and computational approach to comprehensive glycation characterization on antibodies
- (2015) Ramsey A Saleem et al. mAbs
- Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation
- (2015) Ewald TJ van den Bremer et al. mAbs
- Comparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles—Part 2: Mass spectrometric methods
- (2015) Dietmar Reusch et al. mAbs
- N-glycan PK Profiling Using a High Sensitivity nanoLCMS Work-Flow with Heavy Stable Isotope Labeled Internal Standard and Application to a Preclinical Study of an IgG1 Biopharmaceutical
- (2015) Fabian Higel et al. PHARMACEUTICAL RESEARCH
- Streptococcal IdeS: therapeutic potential for Guillain–Barré syndrome
- (2015) Ryo Takahashi et al. Scientific Reports
- Complete Removal of Extracellular IgG Antibodies in a Randomized Dose-Escalation Phase I Study with the Bacterial Enzyme IdeS – A Novel Therapeutic Opportunity
- (2015) Lena Winstedt et al. PLoS One
- Advantages of Extended Bottom-Up Proteomics Using Sap9 for Analysis of Monoclonal Antibodies
- (2014) Kristina Srzentić et al. ANALYTICAL CHEMISTRY
- Middle-Down Analysis of Monoclonal Antibodies with Electron Transfer Dissociation Orbitrap Fourier Transform Mass Spectrometry
- (2014) Luca Fornelli et al. ANALYTICAL CHEMISTRY
- From High- to Super-resolution Mass Spectrometry
- (2014) Yury O. Tsybin CHIMIA
- LC–MS analysis of polyclonal IgGs using IdeS enzymatic proteolysis for oxidation monitoring
- (2014) Yann Leblanc et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Extended bottom-up proteomics with secreted aspartic protease Sap9
- (2014) Ünige A. Laskay et al. Journal of Proteomics
- Biosimilars entering the clinic without animal studies
- (2014) Leon AGJM van Aerts et al. mAbs
- A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies
- (2014) Jan Stracke et al. mAbs
- Comparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles—Part 1: Separation-based methods
- (2014) Dietmar Reusch et al. mAbs
- Versatile characterization of glycosylation modification in CTLA4-Ig fusion proteins by liquid chromatography-mass spectrometry
- (2014) Lei Zhu et al. mAbs
- A new tool for monoclonal antibody analysis
- (2014) Yan An et al. mAbs
- The therapeutic monoclonal antibody market
- (2014) Dawn M Ecker et al. mAbs
- Immunoglobulin G (IgG) Fab Glycosylation Analysis Using a New Mass Spectrometric High-throughput Profiling Method Reveals Pregnancy-associated Changes
- (2014) Albert Bondt et al. MOLECULAR & CELLULAR PROTEOMICS
- Complement Is Activated by IgG Hexamers Assembled at the Cell Surface
- (2014) C. A. Diebolder et al. SCIENCE
- Assessing analytical methods to monitor isoAsp formation in monoclonal antibodies
- (2014) Catherine M. Eakin et al. Frontiers in Pharmacology
- Structural comparison of two anti-CD20 monoclonal antibody drug products using middle-down mass spectrometry
- (2013) Bo Wang et al. ANALYST
- Nondenaturing Size-Exclusion Chromatography-Mass Spectrometry to Measure Stress-Induced Aggregation in a Complex Mixture of Monoclonal Antibodies
- (2013) Jonathan Woodard et al. ANALYTICAL CHEMISTRY
- N- and O-Glycosylation Analysis of Etanercept Using Liquid Chromatography and Quadrupole Time-of-Flight Mass Spectrometry Equipped with Electron-Transfer Dissociation Functionality
- (2013) Stephane Houel et al. ANALYTICAL CHEMISTRY
- The carbohydrate switch between pathogenic and immunosuppressive antigen-specific antibodies
- (2013) Mattias Collin et al. EXPERIMENTAL DERMATOLOGY
- Rapid IgG heavy chain cleavage by the streptococcal IgG endopeptidase IdeS is mediated by IdeS monomers and is not due to enzyme dimerization
- (2013) Reine Vindebro et al. FEBS LETTERS
- Mass spectrometry for the biophysical characterization of therapeutic monoclonal antibodies
- (2013) Hao Zhang et al. FEBS LETTERS
- Protein Digestion: An Overview of the Available Techniques and Recent Developments
- (2013) Linda Switzar et al. JOURNAL OF PROTEOME RESEARCH
- Rapid Fc glycosylation analysis of Fc fusions with IdeS and liquid chromatography mass spectrometry
- (2013) Heather Lynaugh et al. mAbs
- Structural analysis of a therapeutic monoclonal antibody dimer by hydroxyl radical footprinting
- (2013) Galahad Deperalta et al. mAbs
- Antibody-drug conjugates
- (2013) Alain Beck et al. mAbs
- Correct primary structure assessment and extensive glyco-profiling of cetuximab by a combination of intact, middle-up, middle-down and bottom-up ESI and MALDI mass spectrometry techniques
- (2013) Daniel Ayoub et al. mAbs
- Antibody-drug conjugate model fast characterization by LC-MS following IdeS proteolytic digestion
- (2013) Elsa Wagner-Rousset et al. mAbs
- Glycoproteomic Analysis of Antibodies
- (2013) Gerhild Zauner et al. MOLECULAR & CELLULAR PROTEOMICS
- Fluorogenic Tagging Methodology Applied to Characterize Oxidized Tyrosine and Phenylalanine in an Immunoglobulin Monoclonal Antibody
- (2013) Shuxia Zhou et al. PHARMACEUTICAL RESEARCH
- Analytical characterization of biosimilar antibodies and Fc-fusion proteins
- (2013) Alain Beck et al. TRAC-TRENDS IN ANALYTICAL CHEMISTRY
- Characterization of critical reagents in ligand-binding assays: enabling robust bioanalytical methods and lifecycle management
- (2013) Brian J Geist et al. Bioanalysis
- IgG Protease Mac/IdeS Is Not Essential for Phagocyte Resistance or Mouse Virulence of M1T1 Group A Streptococcus
- (2013) C. Y. M. Okumura et al. mBio
- Characterization of Therapeutic Antibodies and Related Products
- (2012) Alain Beck et al. ANALYTICAL CHEMISTRY
- Exploring an Orbitrap Analyzer for the Characterization of Intact Antibodies by Native Mass Spectrometry
- (2012) Sara Rosati et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Identification of a Novel Host-Specific IgM Protease in Streptococcus suis
- (2012) J. Seele et al. JOURNAL OF BACTERIOLOGY
- Quantitative glycan profiling of normal human plasma derived immunoglobulin and its fragments Fab and Fc
- (2012) Kalyan Rao Anumula JOURNAL OF IMMUNOLOGICAL METHODS
- Streptococcal IdeS and Its Impact on Immune Response and Inflammation
- (2012) Ulrich von Pawel-Rammingen Journal of Innate Immunity
- Characterization of Fc-Fusion Protein Aggregates Derived from Extracellular Domain Disulfide Bond Rearrangements
- (2012) James Strand et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Disulfide bond structures of IgG molecules
- (2012) Hongcheng Liu et al. mAbs
- Analysis and Functional Consequences of Increased Fab-Sialylation of Intravenous Immunoglobulin (IVIG) after Lectin Fractionation
- (2012) Fabian Käsermann et al. PLoS One
- Sialylation-independent mechanism involved in the amelioration of murine immune thrombocytopenia using intravenous gammaglobulin
- (2012) Danila Leontyev et al. TRANSFUSION
- Fast analysis of recombinant monoclonal antibodies using IdeS proteolytic digestion and electrospray mass spectrometry
- (2011) Guillaume Chevreux et al. ANALYTICAL BIOCHEMISTRY
- Cysteine proteinase SpeB from Streptococcus pyogenes – a potent modifier of immunologically important host and bacterial proteins
- (2011) Daniel C. Nelson et al. BIOLOGICAL CHEMISTRY
- High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans
- (2011) A. M. Goetze et al. GLYCOBIOLOGY
- Rates and impact of human antibody glycation in vivo
- (2011) A. M. Goetze et al. GLYCOBIOLOGY
- Rapid LC–MS screening for IgG Fc modifications and allelic variants in blood
- (2011) Andrew M. Goetze et al. MOLECULAR IMMUNOLOGY
- Cleavage of IgGs by proteases associated with invasive diseases
- (2010) Randall J. Brezski et al. mAbs
- Separation of 2-aminobenzamide labeled glycans using hydrophilic interaction chromatography columns packed with 1.7μm sorbent
- (2009) Joomi Ahn et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Trends in Glycosylation, Glycoanalysis and Glycoengineering of Therapeutic Antibodies and Fc-Fusion Proteins
- (2008) Alain Beck et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Mass spectrometry for structural characterization of therapeutic antibodies
- (2008) Zhongqi Zhang et al. MASS SPECTROMETRY REVIEWS
- Cetuximab-Induced Anaphylaxis and IgE Specific for Galactose-α-1,3-Galactose
- (2008) Christine H. Chung et al. NEW ENGLAND JOURNAL OF MEDICINE
- IdeS: A Bacterial Proteolytic Enzyme with Therapeutic Potential
- (2008) Björn P. Johansson et al. PLoS One
- Making autoantibodies safe
- (2008) C. N. Scanlan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started