Article
Immunology
Mingjie Jin, Siyu Liang, Jing Wang, Huihui Zhang, Yueling Zhang, Wanjiang Zhang, Siguo Liu, Fang Xie
Summary: This study reveals the important role of the PepO protease in Streptococcus suis by assisting the bacterium in resisting cathelicidin-mediated killing. PepO cleaves and degrades cathelicidins LL-37 and mCRAMP, impairing their antibacterial abilities and affecting neutrophil migration, anti-apoptosis activity, and lysosome development in macrophages. Furthermore, the loss of PepO attenuates organ injury and bacterial burdens in a murine model of S. suis bacteraemia.
Review
Microbiology
Mareva Bleuze, Marcelo Gottschalk, Mariela Segura
Summary: Streptococcus suis infection can lead to various clinical manifestations mainly due to exacerbated inflammation, in which neutrophils play a key role. However, research on the functions and roles of neutrophils in Streptococcus suis infection is still limited.
Article
Medicine, Research & Experimental
Xingxing Dong, Yanjie Chao, Yang Zhou, Rui Zhou, Wei Zhang, Vincent A. Fischetti, Xiaohong Wang, Ye Feng, Jinquan Li
Summary: Researchers have identified a new human-associated clade of Streptococcus suis, named HAC, originating from European swine breeds exported in the 1960s and 1970s. The formation of HAC reveals healthy-pig carriers as a potential source for human infection, and new HAC-specific genes serve as promising markers for pathogen detection and surveillance.
EMBO MOLECULAR MEDICINE
(2021)
Review
Microbiology
Muriel Dresen, Peter Valentin-Weigand, Yenehiwot Berhanu Weldearegay
Summary: This review focuses on the role of Streptococcus suis metabolism in adapting to different in vivo host niches, as well as its link to virulence. The potential of targeting metabolic pathways for new therapeutic strategies is also discussed.
Article
Immunology
Chengpei Ni, Yi Han, Yajing Wang, Ting Ma, Dan Sha, Yanan Xu, Wenting Cao, Song Gao
Summary: This study evaluates the differences between humanized HLA and murine H2 in Streptococcus suis (S. suis) infection using humanized transgenic mice. The results show that humanized mice exhibit heightened pro-inflammatory responses, exacerbated tissue damage, increased granulocyte recruitment, and impaired resolution compared to wild-type mice. The humanized mice model can serve as an optimal animal model for investigating the pathogenic and therapeutic mechanisms associated with sepsis and other infectious diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Engineering, Multidisciplinary
Chaoyang Zhang, Lu Liu, Peng Zhang, Jingpo Cui, Xiaoxia Qin, Lichao Ma, Kun Han, Zhanhui Wang, Shaolin Wang, Shuangyang Ding, Zhangqi Shen
Summary: Antimicrobial resistance is a major global health threat. This study identified a new resistance gene, srpA, in Streptococcus suis, which mediates resistance to multiple antibiotics. Functional analysis revealed that srpA protects the ribosome and clarifies the mechanisms underlying resistance to ribosomal antibiotics.
Article
Immunology
Xinchi Zhu, Shuoyue Wang, Yu Du, Zijing Liang, Huochun Yao, Xiang Chen, Zongfu Wu
Summary: This study utilized RNA-Seq to reveal the transcriptional landscape of Streptococcus suis under oxidative stress. Several novel genes responsible for resisting oxidative stress were identified, along with a novel aquaporin, Aagp, which plays a crucial role during hydrogen peroxide stress. Additionally, Aagp may be involved in glycerol transport and contributes to S. suis virulence.
Article
Immunology
Pengjiang Yang, Lei Yang, Kun Cao, Qian Hu, Yuli Hu, Jun Shi, Dun Zhao, Xinglong Yu
Summary: The Cba protein of Streptococcus suis is a collagen adhesin that plays a role in biofilm formation, host cell adhesion, phagocytic resistance, and virulence. Knocking out the cba gene significantly impairs these functions. Furthermore, immunization with the Cba protein enhances the severity of infection, suggesting the presence of antibody-dependent enhancement in Streptococcus suis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Li Yi, Manyu Jin, Mengxia Gao, Haikun Wang, Qingying Fan, Daniel Grenier, Liyun Sun, Shaohui Wang, Yang Wang
Summary: Respiratory infections greatly impact the swine industry globally, with co-infections of Streptococcus suis and Actinobacillus pleuropneumoniae often forming biofilms. However, the methods for detecting these bacteria in co-infections and biofilms are immature. This study successfully established a TaqMan real-time PCR method for simultaneous detection of S. suis and A. pleuropneumoniae, which may aid in disease detection, prevention, and control.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Zijing Wang, Xiao Liu, Zhaoxin Shi, Rihong Zhao, Yalu Ji, Fang Tang, Yuan Guan, Xin Feng, Changjiang Sun, Liancheng Lei, Wenyu Han, Xiang-Dang Du, Jingmin Gu
Summary: A novel lysin, Ply1228, derived from the prophage of Streptococcus suis type 12, was found to have specific lytic activity against various S. suis strains and demonstrated therapeutic potential in a mouse model of S. suis bacteremia.
VETERINARY MICROBIOLOGY
(2022)
Review
Immunology
Thomas J. Roodsant, Boas C. L. van der Putten, Sara M. Tamminga, Constance Schultsz, Kees C. H. van der Ark
Summary: This study identified virulence factors that likely contribute to the zoonotic potential of Streptococcus suis through a systematic review and genomic meta-analysis. Over 50 potential virulence factors were identified in the core genome, with 26 being more prevalent in human isolates. Notably, Hhly3 and NisR/K were particularly enriched in human isolates.
Article
Multidisciplinary Sciences
Warangkhana Songsungthong, Sunisa Prasopporn, Louise Bohan, Potjanee Srimanote, Ubolsree Leartsakulpanich, Suganya Yongkiettrakul
Summary: This study screened the Pathogen Box compound library and identified 30 compounds that effectively inhibit the growth of Streptococcus suis, with MMV675968 being the most potent. MMV675968 was found to target S. suis dihydrofolate reductase and showed better efficacy compared to other DHFR inhibitors, serving as a potential starting point for developing antibiotics against drug resistant S. suis.
Article
Veterinary Sciences
Qiankun Bai, Ruhui Fan, Ningyuan Zhong, Jianan Liu, Xinming Pan, Huochun Yao, Jiale Ma
Summary: This study explores the role of Pentraxin 3 (PTX3) during Streptococcus suis serotype 2 (SS2) infection and verifies its potential as a new and effective biological agent. The results showed that PTX3 facilitates phagocytosis, inflammatory cell recruitment, and cytokine IL-6 release, contributing to bacterial clearance during SS2 infection. The presence of capsular polysaccharide of SS2 (CPS2) is required for PTX3 to trigger the inflammatory response, suggesting PTX3 as a potential biological agent for prevention and treatment of SS2-related streptococcosis.
VETERINARY SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Mengxia Gao, Jing Zuo, Yamin Shen, Shuo Yuan, Shuji Gao, Yuxin Wang, Yang Wang, Li Yi
Summary: In this study, the interaction between Streptococcus suis (S. suis) and Haemophilus parasuis (H. parasuis) was investigated during single infections and co-infections. It was found that these two pathogens compete in vitro, but synergistically increase colonization capacity after co-infection in vivo. The expression of virulence genes and susceptibility to antibiotics were also different in mixed culture compared to single culture. These findings highlight the importance of considering mixed species interactions in bacterial disease control and antibiotic treatment.
Article
Veterinary Sciences
April A. Estrada, Marcelo Gottschalk, Connie J. Gebhart, Douglas G. Marthaler
Summary: Pan-genome analysis of Streptococcus suis identified novel candidate virulence-associated genes (VAGs) and proposed a genotyping scheme for predicting pathogenicity. Mobile genetic elements carrying antimicrobial resistance genes (ARGs) were also identified.
VETERINARY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Christian Spoerry, Jana Seele, Peter Valentin-Weigand, Christoph G. Baums, Ulrich von Pawel-Rammingen
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Reine Vindebro, Christian Spoerry, Ulrich von Pawel-Rammingen
Article
Chemistry, Medicinal
Kristina Berggren, Reine Vindebro, Claes Bergstrom, Christian Spoerry, Helena Persson, Tomas Fex, Jan Kihlberg, Ulrich von Pawel-Rammingen, Kristina Luthmant
JOURNAL OF MEDICINAL CHEMISTRY
(2012)
Article
Multidisciplinary Sciences
Christian Spoerry, Pontus Hessle, Melanie J. Lewis, Lois Paton, Jenny M. Woof, Ulrich von Pawel-Rammingen
Correction
Multidisciplinary Sciences
Christian Spoerry, Pontus Hessle, Melanie J. Lewis, Lois Paton, Jenny M. Woof, Ulrich von Pawel-Rammingen