Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation
Authors
Keywords
-
Journal
mAbs
Volume 7, Issue 4, Pages 672-680
Publisher
Informa UK Limited
Online
2015-06-03
DOI
10.1080/19420862.2015.1046665
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Method development for the separation of monoclonal antibody charge variants in cation exchange chromatography, Part I: Salt gradient approach
- (2015) Szabolcs Fekete et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Therapeutic monoclonal antibodies and consistent ends: terminal heterogeneity, detection, and impact on quality
- (2014) Kurt Brorson et al. CURRENT OPINION IN BIOTECHNOLOGY
- In vitro and in vivo modifications of recombinant and human IgG antibodies
- (2014) Hongcheng Liu et al. mAbs
- Complement Is Activated by IgG Hexamers Assembled at the Cell Surface
- (2014) C. A. Diebolder et al. SCIENCE
- Investigation of the correlation between charge and glycosylation of IgG1 variants by liquid chromatography–mass spectrometry
- (2013) Jia-Ming Yang et al. ANALYTICAL BIOCHEMISTRY
- Correct primary structure assessment and extensive glyco-profiling of cetuximab by a combination of intact, middle-up, middle-down and bottom-up ESI and MALDI mass spectrometry techniques
- (2013) Daniel Ayoub et al. mAbs
- Conformational characterization of the charge variants of a human IgG1 monoclonal antibody using H/D exchange mass spectrometry
- (2013) Liangjie Tang et al. mAbs
- Antibody Therapeutics in Cancer
- (2013) M. X. Sliwkowski et al. SCIENCE
- Characterization of Therapeutic Antibodies and Related Products
- (2012) Alain Beck et al. ANALYTICAL CHEMISTRY
- Probing of C-terminal lysine variation in a recombinant monoclonal antibody production using Chinese hamster ovary cells with chemically defined media
- (2012) Jun Luo et al. BIOTECHNOLOGY AND BIOENGINEERING
- Exhaustion of Cytotoxic Effector Systems May Limit Monoclonal Antibody-Based Immunotherapy in Cancer Patients
- (2012) F. J. Beurskens et al. JOURNAL OF IMMUNOLOGY
- Worldwide experience with biosimilar development
- (2011) Mark McCamish et al. mAbs
- C-terminal lysine processing of human immunoglobulin G2 heavy chain in vivo
- (2010) Bing Cai et al. BIOTECHNOLOGY AND BIOENGINEERING
- Daratumumab, a Novel Therapeutic Human CD38 Monoclonal Antibody, Induces Killing of Multiple Myeloma and Other Hematological Tumors
- (2010) M. de Weers et al. JOURNAL OF IMMUNOLOGY
- Development trends for human monoclonal antibody therapeutics
- (2010) Aaron L. Nelson et al. NATURE REVIEWS DRUG DISCOVERY
- Binding of Submaximal C1q Promotes Complement-Dependent Cytotoxicity (CDC) of B Cells Opsonized with Anti-CD20 mAbs Ofatumumab (OFA) or Rituximab (RTX): Considerably Higher Levels of CDC Are Induced by OFA than by RTX
- (2009) A. W. Pawluczkowycz et al. JOURNAL OF IMMUNOLOGY
- Glycosylation as a strategy to improve antibody-based therapeutics
- (2009) Roy Jefferis NATURE REVIEWS DRUG DISCOVERY
- C-terminal lysine variants in fully human monoclonal antibodies: Investigation of test methods and possible causes
- (2008) Lawrence W. Dick et al. BIOTECHNOLOGY AND BIOENGINEERING
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started