The carbohydrate switch between pathogenic and immunosuppressive antigen-specific antibodies

Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition

(2013) Khaled Amara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impact of Immune Complex Size and Glycosylation on IgG Binding to Human Fc Rs

(2013) A. Lux et al.   JOURNAL OF IMMUNOLOGY

Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers

(2013) Gordan Lauc et al.   PLoS Genetics

IVIg-mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1

(2012) Inessa Schwab et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pathogenesis of Bullous Pemphigoid

(2012) Hideyuki Ujiie et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Tolerance induction with T cell–dependent protein antigens induces regulatory sialylated IgGs

(2012) Carolin M. Oefner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Enzymatic autoantibody glycan hydrolysis alleviates autoimmunity against type VII collagen

(2012) Misa Hirose et al.   JOURNAL OF AUTOIMMUNITY

IgG glycan hydrolysis by EndoS inhibits experimental autoimmune encephalomyelitis

(2012) Mahdia Benkhoucha et al.   Journal of Neuroinflammation

Intravenous Immunoglobulin Expands Regulatory T Cells in Autoimmune Rheumatic Disease

(2012) J. BAYRY et al.   JOURNAL OF RHEUMATOLOGY

IgG Glycosylation Changes and MBL2 Polymorphisms: Associations with Markers of Systemic Inflammation and Joint Destruction in Rheumatoid Arthritis

(2012) L. N. TROELSEN et al.   JOURNAL OF RHEUMATOLOGY

Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1

(2012) Christian M Karsten et al.   NATURE MEDICINE

Analysis and Functional Consequences of Increased Fab-Sialylation of Intravenous Immunoglobulin (IVIG) after Lectin Fractionation

(2012) Fabian Käsermann et al.   PLoS One

Frequency of Th17 CD4+ T Cells in Early Rheumatoid Arthritis: A Marker of Anti-CCP Seropositivity

(2012) Irene Arroyo-Villa et al.   PLoS One

Sialylation-independent mechanism involved in the amelioration of murine immune thrombocytopenia using intravenous gammaglobulin

(2012) Danila Leontyev et al.   TRANSFUSION

Pathogenesis of Epidermolysis Bullosa Acquisita

(2011) Ralf J. Ludwig et al.   DERMATOLOGIC CLINICS

New targets of pemphigus vulgaris antibodies identified by protein array technology

(2011) Mina Kalantari-Dehaghi et al.   EXPERIMENTAL DERMATOLOGY

Complement-Fixing Anti-Type VII Collagen Antibodies Are Induced in Th1-Polarized Lymph Nodes of Epidermolysis Bullosa Acquisita-Susceptible Mice

(2011) Christoph M. Hammers et al.   JOURNAL OF IMMUNOLOGY

TLR9 in Peritoneal B-1b Cells Is Essential for Production of Protective Self-Reactive IgM To Control Th17 Cells and Severe Autoimmunity

(2011) A. D. Stoehr et al.   JOURNAL OF IMMUNOLOGY

Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway

(2011) Robert M. Anthony et al.   NATURE

Intravenous immunoglobulin therapy in rheumatic diseases

(2011) Jagadeesh Bayry et al.   Nature Reviews Rheumatology

Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis

(2010) Altan Ercan et al.   ARTHRITIS AND RHEUMATISM

Glycan profiling of anti-citrullinated protein antibodies isolated from human serum and synovial fluid

(2010) Hans U. Scherer et al.   ARTHRITIS AND RHEUMATISM

Role of Th17 cells in human autoimmune arthritis

(2010) Jan Leipe et al.   ARTHRITIS AND RHEUMATISM

The IgG-specific endoglycosidase EndoS inhibits both cellular and complement-mediated autoimmune hemolysis

(2010) M. Allhorn et al.   BLOOD

Lymphocytes from patients with rheumatoid arthritis produce agalactosylated IgG in vitro

(2010) K. B. BODMAN et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

What’s new in bullous pemphigoid

(2010) Hideyuki UJIIE et al.   JOURNAL OF DERMATOLOGY

Development of self-reactive germinal center B cells and plasma cells in autoimmune FcγRIIB-deficient mice

(2010) Thomas Tiller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Generation of Antibodies of Distinct Subclasses and Specificity Is Linked to H2s in an Active Mouse Model of Epidermolysis Bullosa Acquisita

(2010) Ralf J. Ludwig et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IgG Glycan Hydrolysis Attenuates ANCA-Mediated Glomerulonephritis

(2010) M. M. van Timmeren et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

(2010) Eli A Stahl et al.   NATURE GENETICS

Successful treatment of experimental glomerulonephritis with IdeS and EndoS, IgG-degrading streptococcal enzymes

(2010) R. Yang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Is IgG galactosylation the relevant factor for pregnancy-induced remission of rheumatoid arthritis?

(2010) Frauke Förger et al.   ARTHRITIS RESEARCH & THERAPY

Toll-like Receptors in Autoimmunity

(2009) Maria Fischer et al.   Annals of the New York Academy of Sciences

Indirect inhibition of in vivo and in vitro T-cell responses by intravenous immunoglobulins due to impaired antigen presentation

(2009) E. Aubin et al.   BLOOD

High-Dose Intravenous Immunoglobulin (IVIG) Therapy in Autoimmune Skin Blistering Diseases

(2009) Norito Ishii et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Pathogenicity of IgG subclass autoantibodies to type VII collagen: Induction of dermal–epidermal separation

(2009) Andreas Recke et al.   JOURNAL OF AUTOIMMUNITY

T Cells Are Required for the Production of Blister-Inducing Autoantibodies in Experimental Epidermolysis Bullosa Acquisita

(2009) A. G. Sitaru et al.   JOURNAL OF IMMUNOLOGY

DC-SIGN and  2,6-sialylated IgG Fc interaction is dispensable for the anti-inflammatory activity of IVIg on human dendritic cells

(2009) J. Bayry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunoglobulin G galactosylation and sialylation are associated with pregnancy-induced improvement of rheumatoid arthritis and the postpartum flare: results from a large prospective cohort study

(2009) Fleur E van de Geijn et al.   ARTHRITIS RESEARCH & THERAPY

Reversible changes in serum immunoglobulin galactosylation during the immune response and treatment of inflammatory autoimmune arthritis

(2008) K Van Beneden et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-Inflammatory Actions of Intravenous Immunoglobulin

(2008) Falk Nimmerjahn et al.   Annual Review of Immunology

Human IgG/FcγR Interactions Are Modulated by Streptococcal IgG Glycan Hydrolysis

(2008) Maria Allhorn et al.   PLoS One

In vivo enzymatic modulation of IgG glycosylation inhibits autoimmune disease in an IgG subclass-dependent manner

(2008) H. Albert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IgG glycan hydrolysis by a bacterial enzyme as a therapy against autoimmune conditions

(2008) M. Collin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a receptor required for the anti-inflammatory activity of IVIG

(2008) R. M. Anthony et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

(2008) R. M. Anthony et al.   SCIENCE

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning

(2007) Thomas Tiller et al.   JOURNAL OF IMMUNOLOGICAL METHODS