EndoS and EndoS2 hydrolyze Fc-glycans on therapeutic antibodies with different glycoform selectivity and can be used for rapid quantification of high-mannose glycans

Bacterial glycosidases in pathogenesis and glycoengineering

(2014) Jonathan Sjögren et al.   Future Microbiology

Fragments of Bacterial Endoglycosidase S and Immunoglobulin G Reveal Subdomains of Each That Contribute to Deglycosylation

(2014) Emma V. Dixon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fc Glycan-Modulated Immunoglobulin G Effector Functions

(2014) Isaak Quast et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Human IgG Fc domain engineering enhances antitoxin neutralizing antibody activity

(2014) Stylianos Bournazos et al.   JOURNAL OF CLINICAL INVESTIGATION

Combined glyco- and protein-Fc engineering simultaneously enhance cytotoxicity and half-life of a therapeutic antibody

(2014) Céline Monnet et al.   mAbs

Type I and type II Fc receptors regulate innate and adaptive immunity

(2014) Andrew Pincetic et al.   NATURE IMMUNOLOGY

Emerging Principles for the Therapeutic Exploitation of Glycosylation

(2014) Martin Dalziel et al.   SCIENCE

EndoS2is a unique and conserved enzyme of serotype M49 group AStreptococcusthat hydrolyses N-linked glycans on IgG and α1-acid glycoprotein

(2013) Jonathan Sjögren et al.   BIOCHEMICAL JOURNAL

Correct primary structure assessment and extensive glyco-profiling of cetuximab by a combination of intact, middle-up, middle-down and bottom-up ESI and MALDI mass spectrometry techniques

(2013) Daniel Ayoub et al.   mAbs

General mechanism for modulating immunoglobulin effector function

(2013) P. Sondermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proposed mechanism of off-target toxicity for antibody–drug conjugates driven by mannose receptor uptake

(2012) Boris Gorovits et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Enzymatic autoantibody glycan hydrolysis alleviates autoimmunity against type VII collagen

(2012) Misa Hirose et al.   JOURNAL OF AUTOIMMUNITY

Bacterial Hydrolysis of Host Glycoproteins – Powerful Protein Modification and Efficient Nutrient Acquisition

(2012) Julia Garbe et al.   Journal of Innate Immunity

Chemoenzymatic Glycoengineering of Intact IgG Antibodies for Gain of Functions

(2012) Wei Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Marketing approval of mogamulizumab

(2012) Alain Beck et al.   mAbs

Study of the IgG endoglycosidase EndoS in group A streptococcal phagocyte resistance and virulence

(2011) Jonathan Sjögren et al.   BMC MICROBIOLOGY

High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans

(2011) A. M. Goetze et al.   GLYCOBIOLOGY

High Throughput Isolation and Glycosylation Analysis of IgG–Variability and Heritability of the IgG Glycome in Three Isolated Human Populations

(2011) Maja Pučić et al.   MOLECULAR & CELLULAR PROTEOMICS

Glycan labeling strategies and their use in identification and quantification

(2010) L. R. Ruhaak et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The IgG-specific endoglycosidase EndoS inhibits both cellular and complement-mediated autoimmune hemolysis

(2010) M. Allhorn et al.   BLOOD

A Novel Role for the IgG Fc Glycan: The Anti-inflammatory Activity of Sialylated IgG Fcs

(2010) Robert M. Anthony et al.   JOURNAL OF CLINICAL IMMUNOLOGY

IgG Glycan Hydrolysis Attenuates ANCA-Mediated Glomerulonephritis

(2010) M. M. van Timmeren et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Proposal for a standard system for drawing structural diagrams ofN- andO-linked carbohydrates and related compounds

(2009) David J. Harvey et al.   PROTEOMICS

Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action

(2009) Royston Jefferis   TRENDS IN PHARMACOLOGICAL SCIENCES

Human IgG/FcγR Interactions Are Modulated by Streptococcal IgG Glycan Hydrolysis

(2008) Maria Allhorn et al.   PLoS One

IgG glycan hydrolysis by a bacterial enzyme as a therapy against autoimmune conditions

(2008) M. Collin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a receptor required for the anti-inflammatory activity of IVIG

(2008) R. M. Anthony et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycosylation of Recombinant Antibody Therapeutics

(2005) Royston Jefferis   BIOTECHNOLOGY PROGRESS