A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies

Characterization of monoclonal antibody size variants containing extra light chains

(2013) Connie Lu et al.   mAbs

Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies

(2013) Tilman Schlothauer et al.   mAbs

Antibodies to watch in 2013

(2013) Janice M Reichert   mAbs

Charge Heterogeneity of Monoclonal Antibodies by Multiplexed Imaged Capillary Isoelectric Focusing Immunoassay with Chemiluminescence Detection

(2012) David A. Michels et al.   ANALYTICAL CHEMISTRY

Monoclonal antibody therapeutics: history and future

(2012) Nicholas APS Buss et al.   CURRENT OPINION IN PHARMACOLOGY

Analytical Protein A Chromatography as a Quantitative Tool for the Screening of Methionine Oxidation in Monoclonal Antibodies

(2012) Caroline Loew et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Neonatal Fc receptor and IgG-based therapeutics

(2011) Timothy T. Kuo et al.   mAbs

Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies

(2011) Weirong Wang et al.   MOLECULAR IMMUNOLOGY

Kinetics of Chemical Degradation in Monoclonal Antibodies: Relationship between Rates at the Molecular and Peptide Levels

(2010) Roxana Ionescu et al.   ANALYTICAL CHEMISTRY

Separation of post-translational modifications in monoclonal antibodies by exploiting subtle conformational changes under mildly acidic conditions

(2010) Shiyi Wang et al.   JOURNAL OF CHROMATOGRAPHY A

Human immunoglobulin allotypes

(2010) Roy Jefferis et al.   mAbs

Charge variants in IgG1

(2010) Leslie A. Khawli et al.   mAbs

Post-translational Modifications Differentially Affect IgG1 Conformation and Receptor Binding

(2010) Damian Houde et al.   MOLECULAR & CELLULAR PROTEOMICS

Enhanced antibody half-life improves in vivo activity

(2010) Jonathan Zalevsky et al.   NATURE BIOTECHNOLOGY

Development trends for human monoclonal antibody therapeutics

(2010) Aaron L. Nelson et al.   NATURE REVIEWS DRUG DISCOVERY

Conformational changes in oxidatively stressed monoclonal antibodies studied by hydrogen exchange mass spectrometry

(2010) William Burkitt et al.   PROTEIN SCIENCE

Impact of methionine oxidation on the binding of human IgG1 to FcRn and Fcγ receptors

(2009) Andrea Bertolotti-Ciarlet et al.   MOLECULAR IMMUNOLOGY

Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn

(2009) Hai Pan et al.   PROTEIN SCIENCE

High-throughput immunoglobulin G N-glycan characterization using rapid resolution reverse-phase chromatography tandem mass spectrometry

(2008) Bradley D. Prater et al.   ANALYTICAL BIOCHEMISTRY

Structure and Stability Changes of Human IgG1 Fc as a Consequence of Methionine Oxidation

(2008) Dingjiang Liu et al.   BIOCHEMISTRY

Effect of methionine oxidation of a recombinant monoclonal antibody on the binding affinity to protein A and protein G

(2008) Georgeen Gaza-Bulseco et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Neonatal Fc Receptor Mediates Internalization of Fc in Transfected Human Endothelial Cells

(2008) Nancy A. Goebl et al.   MOLECULAR BIOLOGY OF THE CELL