Assessing analytical methods to monitor isoAsp formation in monoclonal antibodies

Fast analysis of recombinant monoclonal antibodies using IdeS proteolytic digestion and electrospray mass spectrometry

(2011) Guillaume Chevreux et al.   ANALYTICAL BIOCHEMISTRY

Analysis of Isoaspartic Acid by Selective Proteolysis with Asp-N and Electron Transfer Dissociation Mass Spectrometry

(2010) Wenqin Ni et al.   ANALYTICAL CHEMISTRY

Electron transfer dissociation with supplemental activation to differentiate aspartic and isoaspartic residues in doubly charged peptide cations

(2010) Wai Yi Kelly Chan et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Asparagine-linked Oligosaccharides Present on a Non-consensus Amino Acid Sequence in the CH1 Domain of Human Antibodies

(2009) John F. Valliere-Douglass et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain

(2009) Boxu Yan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Separation and Characterization of an IgG2 Antibody Containing a Cyclic Imide in CDR1 of Light Chain by Hydrophobic Interaction Chromatography and Mass Spectrometry

(2008) John Valliere-Douglass et al.   ANALYTICAL CHEMISTRY

Isomerization of a Single Aspartyl Residue of Anti-Epidermal Growth Factor Receptor Immunoglobulin γ2 Antibody Highlights the Role Avidity Plays in Antibody Activity

(2008) Douglas S. Rehder et al.   BIOCHEMISTRY

Trends in Glycosylation, Glycoanalysis and Glycoengineering of Therapeutic Antibodies and Fc-Fusion Proteins

(2008) Alain Beck et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Molecular mass analysis of antibodies by on-line SEC-MS

(2008) Lowell J. Brady et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Toward biosimilar monoclonal antibodies

(2008) Christian K Schneider et al.   NATURE BIOTECHNOLOGY

Protein Isoaspartate Methyltransferase Prevents Apoptosis Induced by Oxidative Stress in Endothelial Cells: Role of Bcl-Xl Deamidation and Methylation

(2008) Amelia Cimmino et al.   PLoS One