Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases
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Title
Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases
Authors
Keywords
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Journal
NATURAL PRODUCT REPORTS
Volume 31, Issue 1, Pages 109-139
Publisher
Royal Society of Chemistry (RSC)
Online
2013-11-30
DOI
10.1039/c3np70065h
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- Identification of 3-hydroxy-β-damascone and related carotenoid-derived aroma compounds as novel potent inducers of Nrf2-mediated phase 2 response with concomitant anti-inflammatory activity
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- A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders
- (2009) Jiyoung Kim et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Kaempferol Suppresses Cisplatin-Induced Apoptosis Via Inductions of Heme Oxygenase-1 and Glutamate-Cysteine Ligase Catalytic Subunit in HEI-OC1 cells
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- Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription
- (2009) Lichuan Yang et al. PLoS One
- Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte
- (2009) Pei-Chun Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Altered Disposition of Acetaminophen in Nrf2-null and Keap1-knockdown Mice
- (2009) Scott A. Reisman et al. TOXICOLOGICAL SCIENCES
- The Absence of the Pro-antioxidant Transcription Factor Nrf2 Exacerbates Experimental Autoimmune Encephalomyelitis
- (2009) Delinda A. Johnson et al. TOXICOLOGICAL SCIENCES
- Nrf2 protects against airway disorders
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- Ginsenoside Rb1 protects against 6-hydroxydopamine-induced oxidative stress by increasing heme oxygenase-1 expression through an estrogen receptor-related PI3K/Akt/Nrf2-dependent pathway in human dopaminergic cells
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- Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene compound
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- Antiviral Activity of Nrf2 in a Murine Model of Respiratory Syncytial Virus Disease
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- (2008) P J Syapin BRITISH JOURNAL OF PHARMACOLOGY
- Multitargeted cancer prevention by quercetin
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- RNAi-Mediated Silencing of Nuclear Factor Erythroid-2-Related Factor 2 Gene Expression in Non-Small Cell Lung Cancer Inhibits Tumor Growth and Increases Efficacy of Chemotherapy
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- Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
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- Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway
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- Resveratrol protects primary rat hepatocytes against oxidative stress damage:
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- The coffee diterpene kahweol induces heme oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stress
- (2008) Yong Pil Hwang et al. FEBS LETTERS
- Naringenin-7-O-glucoside protects against doxorubicin-induced toxicity in H9c2 cardiomyocytes by induction of endogenous antioxidant enzymes
- (2008) Xiuzhen Han et al. FOOD AND CHEMICAL TOXICOLOGY
- Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress
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- (2008) Rachana Patel et al. FREE RADICAL BIOLOGY AND MEDICINE
- Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer
- (2008) Tatsuhiro Shibata et al. GASTROENTEROLOGY
- Nuclear Factor-Eythroid 2–Related Factor 2 Prevents Alcohol-Induced Fulminant Liver Injury
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- Phosphorylation and Dephosphorylation of Tyrosine 141 Regulate Stability and Degradation of INrf2
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- Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes
- (2008) Xiaoqing He et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- GSK-3β down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress
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- Nuclear Erythroid 2-Related Factor 2-Antioxidative Response Element Signaling Pathway in Motor Cortex and Spinal Cord in Amyotrophic Lateral Sclerosis
- (2008) Alexander Sarlette et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- NF-E2-Related Factor 2 Inhibits Lipid Accumulation and Oxidative Stress in Mice Fed a High-Fat Diet
- (2008) Y. Tanaka et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Risk factors for cardiovascular disease in women: Relationship to lipid peroxidation and oxidative stress
- (2008) J. Esteban Castelao et al. MEDICAL HYPOTHESES
- Dibenzoylmethane Activates Nrf2-Dependent Detoxification Pathway and Inhibits Benzo(a)pyrene Induced DNA Adducts in Lungs
- (2008) R. Thimmulappa et al. Medicinal Chemistry
- Nuclear factor erythroid 2-related factor 2 protects against beta amyloid
- (2008) Katja Kanninen et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Kavalactones Protect Neural Cells against Amyloid Peptide-Induced Neurotoxicity via Extracellular Signal-Regulated Kinase 1/2-Dependent Nuclear Factor Erythroid 2-Related Factor 2 Activation
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- Hormetic Dietary Phytochemicals
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- Dual roles of Nrf2 in cancer
- (2008) A LAU et al. PHARMACOLOGICAL RESEARCH
- Disruption of Nrf2, a Key Inducer of Antioxidant Defenses, Attenuates ApoE-Mediated Atherosclerosis in Mice
- (2008) Thomas E. Sussan et al. PLoS One
- Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
- (2008) T. Shibata et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2–Keap1 signaling
- (2008) Narayanan Sriram et al. PULMONARY PHARMACOLOGY & THERAPEUTICS
- A Possible Role of Nrf2 in Prevention of Renal Oxidative Damage by Ferric Nitrilotriacetate
- (2008) Keita Kanki et al. TOXICOLOGIC PATHOLOGY
- Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity
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- Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes inmice
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- Mechanism of phytoestrogen puerarin-mediated cytoprotection following oxidative injury: Estrogen receptor-dependent up-regulation of PI3K/Akt and HO-1
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- Comparison of citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice
- (2008) Misty Prince et al. TOXICOLOGY LETTERS
- Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets
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- Role of the Nrf2-antioxidant system in cytotoxicity mediated by anticancer cisplatin: Implication to cancer cell resistance
- (2007) Jeong-Min Cho et al. CANCER LETTERS
- Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG
- (2007) Hye-Kyung Na et al. FOOD AND CHEMICAL TOXICOLOGY
- Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1
- (2007) E. Olatunde Farombi et al. FOOD AND CHEMICAL TOXICOLOGY
- Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: Therapeutic implications for Parkinson's disease explained via in silico studies
- (2007) Balusamy Jagatha et al. FREE RADICAL BIOLOGY AND MEDICINE
- Carnosic acid, acatechol-typeelectrophilic compound, protects neurons bothin vitroandin vivothrough activation of the Keap1/Nrf2 pathway viaS-alkylation of targeted cysteines on Keap1
- (2007) Takumi Satoh et al. JOURNAL OF NEUROCHEMISTRY
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