BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

Nrf2 is associated with the regulation of basal transcription activity of the BRCA1 gene

(2013) Qiaoqiao Wang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Abstract 4028: Therapeutic relevance of two novel cancer candidate genes,RASAL2andNENF, activated by DNA hypomethylation

(2012) Barbara Stefanska et al.   CANCER RESEARCH

AberrantKeap1methylation in breast cancer and association with clinicopathological features

(2012) Raffaela Barbano et al.   Epigenetics

HSCs: stressing out over ROS

(2011) Q. Pang   BLOOD

MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism

(2011) Muhua Yang et al.   BREAST CANCER RESEARCH AND TREATMENT

Catechol metabolites of endogenous estrogens induce redox cycling and generate reactive oxygen species in breast epithelial cells

(2011) Karma C. Fussell et al.   CARCINOGENESIS

Tumor suppressor genes and ROS: complex networks of interactions

(2011) Beyza Vurusaner et al.   FREE RADICAL BIOLOGY AND MEDICINE

BRCA1 tumour suppression occurs via heterochromatin-mediated silencing

(2011) Quan Zhu et al.   NATURE

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155

(2011) Suhwan Chang et al.   NATURE MEDICINE

Detoxification: A Novel Function of BRCA1 in Tumor Suppression?

(2011) Hyo Jin Kang et al.   TOXICOLOGICAL SCIENCES

Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells

(2011) Richard Marcotte et al.   Cancer Discovery

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Progesterone induces adult mammary stem cell expansion

(2010) Purna A. Joshi et al.   NATURE

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

(2010) Peter Bouwman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Susceptibility Pathways in Fanconi's Anemia and Breast Cancer

(2010) Alan D. D'Andrea   NEW ENGLAND JOURNAL OF MEDICINE

Triple-Negative Breast Cancer

(2010) William D. Foulkes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit

(2010) C E Smart et al.   ONCOGENE

Mitochondrial Glutathione, a Key Survival Antioxidant

(2009) Montserrat Marí et al.   ANTIOXIDANTS & REDOX SIGNALING

Subtypes of familial breast tumours revealed by expression and copy number profiling

(2009) Nic Waddell et al.   BREAST CANCER RESEARCH AND TREATMENT

Preclinical mouse models for BRCA1-associated breast cancer

(2009) R M Drost et al.   BRITISH JOURNAL OF CANCER

Nrf2: friend or foe for chemoprevention?

(2009) T. W. Kensler et al.   CARCINOGENESIS

BRCA1 down-regulates cellular levels of reactive oxygen species

(2009) Tapas Saha et al.   FEBS LETTERS

Efficacy of interleukin-13 receptor-targeted liposomal doxorubicin in the intracranial brain tumor model

(2009) A. B. Madhankumar et al.   MOLECULAR CANCER THERAPEUTICS

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

(2009) Weimin Chen et al.   MOLECULAR CELL

A Selective Requirement for 53BP1 in the Biological Response to Genomic Instability Induced by Brca1 Deficiency

(2009) Liu Cao et al.   MOLECULAR CELL

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Molecular mechanisms of Nrf2-mediated antioxidant response

(2008) Wenge Li et al.   MOLECULAR CARCINOGENESIS

BRCA1—sowing the seeds crooked in the furrow

(2007) William D Foulkes   NATURE GENETICS