Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis
Authors
Keywords
Type 2 diabetes, Genetic loci, Isoleucine, Amino acid analysis, Meta-analysis, Leucine, Metabolic pathways, Valine
Journal
PLOS MEDICINE
Volume 13, Issue 11, Pages e1002179
Publisher
Public Library of Science (PLoS)
Online
2016-11-30
DOI
10.1371/journal.pmed.1002179
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Association Between Low-Density Lipoprotein Cholesterol–Lowering Genetic Variants and Risk of Type 2 Diabetes
- (2016) Luca A. Lotta et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Human gut microbes impact host serum metabolome and insulin sensitivity
- (2016) Helle Krogh Pedersen et al. NATURE
- A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease
- (2016) Robert A. Scott et al. Science Translational Medicine
- Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Cardiovascular Epidemiology and Genetics
- (2015) Pasi Soininen et al. Circulation-Cardiovascular Genetics
- Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans
- (2015) Erin L. Glynn et al. DIABETOLOGIA
- Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study
- (2015) Therese Tillin et al. DIABETOLOGIA
- Metabolomic Profile Associated With Insulin Resistance and Conversion to Diabetes in the Insulin Resistance Atherosclerosis Study
- (2015) Nicholette D. Palmer et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Effect of Naturally Random Allocation to Lower Low-Density Lipoprotein Cholesterol on the Risk of Coronary Heart Disease Mediated by Polymorphisms in NPC1L1, HMGCR, or Both
- (2015) Brian A. Ference et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- New genetic loci link adipose and insulin biology to body fat distribution
- (2015) Dmitry Shungin et al. NATURE
- Genetic studies of body mass index yield new insights for obesity biology
- (2015) Adam E. Locke et al. NATURE
- Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis
- (2015) Po-Ru Loh et al. NATURE GENETICS
- An atlas of genetic correlations across human diseases and traits
- (2015) Brendan Bulik-Sullivan et al. NATURE GENETICS
- Combining information on multiple instrumental variables in Mendelian randomization: comparison of allele score and summarized data methods
- (2015) Stephen Burgess et al. STATISTICS IN MEDICINE
- Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study
- (2015) Søren D. Østergaard et al. PLOS MEDICINE
- Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Cardiovascular Epidemiology and Genetics
- (2015) Pasi Soininen et al. Circulation-Cardiovascular Genetics
- Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism
- (2014) Andrew C. Shin et al. Cell Metabolism
- Impaired Adiponectin Signaling Contributes to Disturbed Catabolism of Branched-Chain Amino Acids in Diabetic Mice
- (2014) Kun Lian et al. DIABETES
- Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity
- (2014) R. A. Scott et al. DIABETES
- Roux-en-Y Gastric Bypass Surgery, but Not Calorie Restriction, Reduces Plasma Branched-Chain Amino Acids in Obese Women Independent of Weight Loss or the Presence of Type 2 Diabetes
- (2014) Mirjam A. Lips et al. DIABETES CARE
- Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase
- (2014) Shih-Chia Tso et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sodium phenylbutyrate decreases plasma branched-chain amino acids in patients with urea cycle disorders
- (2014) Lindsay C. Burrage et al. MOLECULAR GENETICS AND METABOLISM
- An atlas of genetic influences on human blood metabolites
- (2014) So-Youn Shin et al. NATURE GENETICS
- Branched-chain amino acids in metabolic signalling and insulin resistance
- (2014) Christopher J. Lynch et al. Nature Reviews Endocrinology
- Inactivating Mutations in NPC1L1 and Protection from Coronary Heart Disease
- (2014) NEW ENGLAND JOURNAL OF MEDICINE
- Metabolic Signatures of Adiposity in Young Adults: Mendelian Randomization Analysis and Effects of Weight Change
- (2014) Peter Würtz et al. PLOS MEDICINE
- A Genome-wide Association Study of the Human Metabolome in a Community-Based Cohort
- (2013) Eugene P. Rhee et al. Cell Metabolism
- Genetic Determinant for Amino Acid Metabolites and Changes in Body Weight and Insulin Resistance in Response to Weight-Loss Diets
- (2013) Min Xu et al. CIRCULATION
- Metabolite Profiles During Oral Glucose Challenge
- (2013) Jennifer E. Ho et al. DIABETES
- Biomarkers for Type 2 Diabetes and Impaired Fasting Glucose Using a Nontargeted Metabolomics Approach
- (2013) C. Menni et al. DIABETES
- Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data
- (2013) Stephen Burgess et al. GENETIC EPIDEMIOLOGY
- Discovery and refinement of loci associated with lipid levels
- (2013) Cristen J Willer et al. NATURE GENETICS
- Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain -ketoacid dehydrogenase kinase
- (2013) S.-C. Tso et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
- (2013) V. K. Ridaura et al. SCIENCE
- A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets
- (2012) Jalal Taneera et al. Cell Metabolism
- Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance
- (2012) Christopher B. Newgard Cell Metabolism
- Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach
- (2012) A. Floegel et al. DIABETES
- The influence of pioglitazone on the plasma amino acid profile in patients with nonalcoholic steatohepatitis (NASH)
- (2012) Eiji Kakazu et al. Hepatology International
- A Novel Regulatory Defect in the Branched-Chain α-Keto Acid Dehydrogenase Complex Due to a Mutation in thePPM1KGene Causes a Mild Variant Phenotype of Maple Syrup Urine Disease
- (2012) Alfonso Oyarzabal et al. HUMAN MUTATION
- What makes UK Biobank special?
- (2012) Rory Collins LANCET
- Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
- (2012) Benjamin F Voight et al. LANCET
- Novel biomarkers for pre-diabetes identified by metabolomics
- (2012) Rui Wang-Sattler et al. Molecular Systems Biology
- Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
- (2012) NATURE GENETICS
- Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
- (2012) Robert A Scott et al. NATURE GENETICS
- A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
- (2012) Alisa K Manning et al. NATURE GENETICS
- Genome-wide association study identifies multiple loci influencing human serum metabolite levels
- (2012) Johannes Kettunen et al. NATURE GENETICS
- Sodium Phenylbutyrate, a Drug With Known Capacity to Reduce Endoplasmic Reticulum Stress, Partially Alleviates Lipid-Induced Insulin Resistance and β-Cell Dysfunction in Humans
- (2011) Changting Xiao et al. DIABETES
- Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study
- (2011) DIABETOLOGIA
- Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans
- (2011) Eugene P. Rhee et al. JOURNAL OF CLINICAL INVESTIGATION
- Metabolite profiles and the risk of developing diabetes
- (2011) Thomas J Wang et al. NATURE MEDICINE
- METAL: fast and efficient meta-analysis of genomewide association scans
- (2010) C. J. Willer et al. BIOINFORMATICS
- Phenylbutyrate therapy for maple syrup urine disease
- (2010) Nicola Brunetti-Pierri et al. HUMAN MOLECULAR GENETICS
- Genotype imputation for genome-wide association studies
- (2010) Jonathan Marchini et al. NATURE REVIEWS GENETICS
- A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance
- (2009) Christopher B. Newgard et al. Cell Metabolism
- Molecular and Metabolic Evidence for Mitochondrial Defects Associated With -Cell Dysfunction in a Mouse Model of Type 2 Diabetes
- (2009) H. Lu et al. DIABETES
- The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver
- (2009) Nicola L. Beer et al. HUMAN MOLECULAR GENETICS
- Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells
- (2009) Gang Lu et al. JOURNAL OF CLINICAL INVESTIGATION
- SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap
- (2008) A. D. Johnson et al. BIOINFORMATICS
- Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
- (2008) Oded Shaham et al. Molecular Systems Biology
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now