XBP1s Is an Anti-lipogenic Protein

Nonalcoholic Fatty Liver Disease

(2015) Mary E. Rinella   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Current efforts and trends in the treatment of NASH

(2015) Vlad Ratziu et al.   JOURNAL OF HEPATOLOGY

Mortality From Chronic Liver Diseases in Diabetes

(2014) Giacomo Zoppini et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

BRD7 Regulates XBP1s’ Activity and Glucose Homeostasis through Its Interaction with the Regulatory Subunits of PI3K

(2014) Sang Won Park et al.   Cell Metabolism

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease

(2014) Gerald I. Shulman   NEW ENGLAND JOURNAL OF MEDICINE

Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s–PPARα axis signalling

(2014) Mengle Shao et al.   Nature Communications

Prevalence of Nonalcoholic Fatty Liver Disease in the United States: The Third National Health and Nutrition Examination Survey, 1988–1994

(2013) Mariana Lazo et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Unfolded Protein Response Signaling and Metabolic Diseases

(2013) Jaemin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-alcoholic fatty liver disease as an independent manifestation of the metabolic syndrome: Results of a US national survey in three ethnic groups

(2013) Mark M Smits et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance

(2013) J. L. Cantley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic Reticulum Stress Sensing in the Unfolded Protein Response

(2013) B. M. Gardner et al.   Cold Spring Harbor Perspectives in Biology

Intrahepatic Diacylglycerol Content Is Associated With Hepatic Insulin Resistance in Obese Subjects

(2012) Faidon Magkos et al.   GASTROENTEROLOGY

The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology

(2012) Naga Chalasani et al.   GASTROENTEROLOGY

Dysfunctional Adiposity and the Risk of Prediabetes and Type 2 Diabetes in Obese Adults

(2012) Ian J. Neeland et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prevalence of Obesity and Trends in the Distribution of Body Mass Index Among US Adults, 1999-2010

(2012) Katherine M. Flegal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism

(2012) Yingfeng Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice

(2011) K. Raddatz et al.   DIABETOLOGIA

The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis

(2011) Kezhong Zhang et al.   EMBO JOURNAL

Frequency and Outcomes of Liver Transplantation for Nonalcoholic Steatohepatitis in the United States

(2011) Michael R. Charlton et al.   GASTROENTEROLOGY

Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice

(2011) Michael J. Jurczak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p38 MAPK–mediated regulation of Xbp1s is crucial for glucose homeostasis

(2011) Jaemin Lee et al.   NATURE MEDICINE

Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction

(2011) Yingjiang Zhou et al.   NATURE MEDICINE

GLP-1 Analogs Reduce Hepatocyte Steatosis and Improve Survival by Enhancing the Unfolded Protein Response and Promoting Macroautophagy

(2011) Shvetank Sharma et al.   PLoS One

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

(2011) N. Kumashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2

(2011) F. R. Jornayvaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study

(2010) Christopher D. Williams et al.   GASTROENTEROLOGY

Tackling of unhealthy diets, physical inactivity, and obesity: health effects and cost-effectiveness

(2010) Michele Cecchini et al.   LANCET

Induction of Liver Steatosis and Lipid Droplet Formation in ATF6α-Knockout Mice Burdened with Pharmacological Endoplasmic Reticulum Stress

(2010) Keisuke Yamamoto et al.   MOLECULAR BIOLOGY OF THE CELL

The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation

(2010) Sang Won Park et al.   NATURE MEDICINE

GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

(2009) Hélène L. Kammoun et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators

(2008) D. Thomas Rutkowski et al.   DEVELOPMENTAL CELL

Endoplasmic Reticulum Stress Is Reduced in Tissues of Obese Subjects After Weight Loss

(2008) M. F. Gregor et al.   DIABETES

Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1

(2008) A.-H. Lee et al.   SCIENCE