Ceramides as modulators of cellular and whole-body metabolism

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling

(2011) Russell A. Miller et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucosylceramide synthase in the fat body controls energy metabolism inDrosophila

(2011) Ayako Kohyama-Koganeya et al.   JOURNAL OF LIPID RESEARCH

Insulin Resistance in Non-Obese Subjects Is Associated with Activation of the JNK Pathway and Impaired Insulin Signaling in Skeletal Muscle

(2011) Umesh B. Masharani et al.   PLoS One

Lipid-induced insulin resistance is prevented in lean and obese myotubes by AICAR treatment

(2010) Benjamin T. Bikman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Inhibition of Glycosphingolipid Synthesis Induces a Profound Reduction of Plasma Cholesterol and Inhibits Atherosclerosis Development in APOE*3 Leiden and Low-Density Lipoprotein Receptor−/− Mice

(2010) Florence Bietrix et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Implication of Sphingomyelin/Ceramide Molar Ratio on the Biological Activity of Sphingomyelinase

(2010) Beate Boulgaropoulos et al.   BIOPHYSICAL JOURNAL

A new take on ceramide: Starving cells by cutting off the nutrient supply

(2010) Garret G. Guenther et al.   CELL CYCLE

Ceramide in Redox Signaling and Cardiovascular Diseases

(2010) Xiang Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Acid Sphingomyelinase/Ceramide Pathway: Biomedical Significance and Mechanisms of Regulation

(2010) Y.H. Zeidan et al.   CURRENT MOLECULAR MEDICINE

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

(2010) J. R. Ussher et al.   DIABETES

Studies on the Role of Acid Sphingomyelinase and Ceramide in the Regulation of Tumor Necrosis Factor α (TNFα)-converting Enzyme Activity and TNFα Secretion in Macrophages

(2010) Krasimira A. Rozenova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kdo2-Lipid A, a TLR4-specific Agonist, Inducesde NovoSphingolipid Biosynthesis in RAW264.7 Macrophages, Which Is Essential for Induction of Autophagy

(2010) Kacee Sims et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blockage of ceramide metabolism exacerbates palmitate inhibition of pro-insulin gene expression in pancreatic β-cells

(2010) Jun Guo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

Fatty acid transport across the cell membrane: Regulation by fatty acid transporters

(2010) Robert W. Schwenk et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis

(2009) Frederic Preitner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

(2009) Guang Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The many ways to regulate glucose transporter 4This paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.

(2009) Amira Klip   Applied Physiology Nutrition and Metabolism

Sphingosine 1-phosphate increases glucose uptake through trans-activation of insulin receptor

(2009) Elena Rapizzi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of Sphingomyelin Hydrolysis: Targeting the Lipid Mediator Ceramide as a Key Regulator of Cellular Fate

(2009) Ralf Claus et al.   CURRENT MEDICINAL CHEMISTRY

Insulin Resistance Is Associated With Higher Intramyocellular Triglycerides in Type I but Not Type II Myocytes Concomitant With Higher Ceramide Content

(2009) P. M. Coen et al.   DIABETES

Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice

(2009) Nora Bijl et al.   HEPATOLOGY

Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice

(2009) Hongmei Zhao et al.   HEPATOLOGY

The c-Jun N-Terminal Kinase Mediates the Induction of Oxidative Stress and Insulin Resistance by Palmitate and Toll-like Receptor 2 and 4 Ligands in 3T3-L1 Adipocytes

(2009) J. Davis et al.   HORMONE AND METABOLIC RESEARCH

Involvement of Acid β-Glucosidase 1 in the Salvage Pathway of Ceramide Formation

(2009) Kazuyuki Kitatani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents

(2009) Stephen C. Benoit et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

(2008) Kelly A. Posey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Targeting of PKCζ and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide

(2008) Eric Hajduch et al.   BIOCHEMICAL JOURNAL

The sphingolipid salvage pathway in ceramide metabolism and signaling

(2008) Kazuyuki Kitatani et al.   CELLULAR SIGNALLING

Prominent increase in plasma ganglioside GM3 is associated with clinical manifestations of type I Gaucher disease

(2008) Karen Ghauharali-van der Vlugt et al.   CLINICA CHIMICA ACTA

Down-Regulation of Phosphatidylinositol 3'-Kinase/AKT/Molecular Target of Rapamycin Metabolic Pathway by Primary Letrozole-Based Therapy in Human Breast Cancer

(2008) D. Generali et al.   CLINICAL CANCER RESEARCH

Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

(2008) S. M. Reyna et al.   DIABETES

Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity

(2008) M. Skovbro et al.   DIABETOLOGIA

Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights fromin VivoManipulation of Sphingolipid Metabolism

(2008) William L. Holland et al.   ENDOCRINE REVIEWS

The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases

(2008) Eric L. Smith et al.   FASEB JOURNAL

Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice

(2008) Gergana M. Deevska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduction of plasma glycosphingolipid levels has no impact on atherosclerosis in apolipoprotein E-null mice

(2008) Elias N. Glaros et al.   JOURNAL OF LIPID RESEARCH

Tlr-4 Deficiency Selectively Protects Against Obesity Induced by Diets High in Saturated Fat

(2008) Jeremy E. Davis et al.   Obesity

Serine palmitoyltransferase inhibitor myriocin induces the regression of atherosclerotic plaques in hyperlipidemic ApoE-deficient mice

(2008) T PARK et al.   PHARMACOLOGICAL RESEARCH

Ceramide starves cells to death by downregulating nutrient transporter proteins

(2008) G. G. Guenther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceramide: A common pathway for atherosclerosis?

(2007) Jean Bismuth et al.   ATHEROSCLEROSIS

Overweight, insulin resistance and type II diabetes in type I Gaucher disease patients in relation to enzyme replacement therapy

(2007) M. Langeveld et al.   BLOOD CELLS MOLECULES AND DISEASES

Type I Gaucher Disease, a Glycosphingolipid Storage Disorder, Is Associated with Insulin Resistance

(2007) Mirjam Langeveld et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM