Paradoxical Lower Serum Triglyceride Levels and Higher Type 2 Diabetes Mellitus Susceptibility in Obese Individuals with the PNPLA3 148M Variant

Mendelian Randomization Studies Do Not Support a Role for Raised Circulating Triglyceride Levels Influencing Type 2 Diabetes, Glucose Levels, or Insulin Resistance

(2011) N. Maneka G. De Silva et al.   DIABETES

Mouse patatin-like phospholipase domain-containing 3 influences systemic lipid and glucose homeostasis

(2011) Aijun Qiao et al.   HEPATOLOGY

The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population

(2011) Chih-Wen Wang et al.   LIVER INTERNATIONAL

The Association of PNPLA3 Variants with Liver Enzymes in Childhood Obesity Is Driven by the Interaction with Abdominal Fat

(2011) Emanuele Miraglia del Giudice et al.   PLoS One

Combined Effect of Inflammatory Gene Polymorphisms and the Risk of Ischemic Stroke in a Prospective Cohort of Subjects With Type 2 Diabetes: A Go-DARTS Study

(2010) C. N. A. Palmer et al.   DIABETES

Effects of PNPLA3 on Liver Fat and Metabolic Profile in Hispanic Children and Adolescents

(2010) M. I. Goran et al.   DIABETES

Patatin-like phospholipase domain-containing 3 and the pathogenesis and progression of pediatric nonalcoholic fatty liver disease

(2010) Jeffrey D. Browning et al.   HEPATOLOGY

Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease

(2010) Weiqin Chen et al.   HEPATOLOGY

I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease

(2010) Luca Valenti et al.   HEPATOLOGY

PNPLA3variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease

(2010) Elizabeth K. Speliotes et al.   HEPATOLOGY

The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life

(2010) Stefano Romeo et al.   JOURNAL OF HEPATOLOGY

Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome

(2010) Mahesh K. Basantani et al.   JOURNAL OF LIPID RESEARCH

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

(2010) Kaixin Zhou et al.   NATURE GENETICS

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

A feed-forward loop amplifies nutritional regulation of PNPLA3

(2010) Yongcheng Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene

(2009) K. Kantartzis et al.   DIABETES

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans

(2009) A. Kotronen et al.   DIABETOLOGIA

Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins

(2009) B. Kollerits et al.   HUMAN MOLECULAR GENETICS

Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent

(2009) S Romeo et al.   INTERNATIONAL JOURNAL OF OBESITY

A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis

(2009) Shaoqing He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overproduction of Very Low–Density Lipoproteins Is the Hallmark of the Dyslipidemia in the Metabolic Syndrome

(2008) Martin Adiels et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Increased Liver Fat, Impaired Insulin Clearance, and Hepatic and Adipose Tissue Insulin Resistance in Type 2 Diabetes

(2008) Anna Kotronen et al.   GASTROENTEROLOGY

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

(2008) Catherine Postic et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS