Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice

A metabolic stress-inducible miR-34a-HNF4α pathway regulates lipid and lipoprotein metabolism

(2015) Yang Xu et al.   Nature Communications

Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD

(2014) Claudia D. Fuchs et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor-controlled lipid homeostasis

(2013) Jiesi Xu et al.   HEPATOLOGY

The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling

(2012) Suneng Fu et al.   Cell Metabolism

The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals

(2012) Young-Ah Moon et al.   Cell Metabolism

Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis

(2012) John Zhong Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of FXR Protects against Diet-Induced Obesity and Accelerates Liver Carcinogenesis inob/obMice

(2012) Yanqiao Zhang et al.   MOLECULAR ENDOCRINOLOGY

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

(2011) Jing-Jie Tang et al.   Cell Metabolism

Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis

(2011) Jiang Wei Wu et al.   HEPATOLOGY

Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis

(2011) Xuemei Ge et al.   JOURNAL OF LIPID RESEARCH

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

Hepatic Hepatocyte Nuclear Factor 4α Is Essential for Maintaining Triglyceride and Cholesterol Homeostasis

(2010) Liya Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat

(2010) Elayne Hondares et al.   Cell Metabolism

Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c

(2010) P. Ferré et al.   DIABETES OBESITY & METABOLISM

Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice

(2010) S. M. Turpin et al.   DIABETOLOGIA

Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning

(2010) Kuok Teong Ong et al.   HEPATOLOGY

A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents

(2010) Nicola Santoro et al.   HEPATOLOGY

PNPLA3variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease

(2010) Elizabeth K. Speliotes et al.   HEPATOLOGY

Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5

(2009) Martina Schweiger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes

(2009) A. Rune et al.   DIABETOLOGIA

GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

(2009) Hélène L. Kammoun et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor α activity

(2009) Jessica M. Sapiro et al.   JOURNAL OF LIPID RESEARCH

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

(2008) E. Bobrovnikova-Marjon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced hepatic expression of adipose tissue triglyceride lipase and CGI-58 may contribute to the development of non-alcoholic fatty liver disease in patients with insulin resistance

(2008) Masaki Kato et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY