Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles

SnapShot: CGAS-STING Signaling

(2018) Lorenzo Galluzzi et al.   CELL

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Cytosolic DNA Sensing Promotes Macrophage Transformation and Governs Myocardial Ischemic Injury

(2018) Dian J. Cao et al.   CIRCULATION

Beneficial effects of acute trans-resveratrol supplementation in treated hypertensive patients with endothelial dysfunction

(2018) B.C.A.A Marques et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

MitoQ improves mitochondrial dysfunction in heart failure induced by pressure overload

(2018) Rogério Faustino Ribeiro Junior et al.   FREE RADICAL BIOLOGY AND MEDICINE

Building and decoding ubiquitin chains for mitophagy

(2018) J. Wade Harper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aspirin Recapitulates Features of Caloric Restriction

(2018) Federico Pietrocola et al.   Cell Reports

P6486The integration of AKI and an elevation in plasma level of high sensitivity cardiac troponin T after PCI predicted more major cardiovascular events in acute coronary syndrome patients

(2017) L. Luo et al.   EUROPEAN HEART JOURNAL

Extracellular nucleosides and nucleotides as immunomodulators

(2017) Oliver Kepp et al.   IMMUNOLOGICAL REVIEWS

Short-term administration of Nicotinamide Mononucleotide preserves cardiac mitochondrial homeostasis and prevents heart failure

(2017) Rongli Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension

(2017) Lian Tian et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Moderate therapeutic hypothermia induces multimodal protective effects in oxygen-glucose deprivation/reperfusion injured cardiomyocytes

(2017) Jana Krech et al.   MITOCHONDRION

Conditional MitoTimer reporter mice for assessment of mitochondrial structure, oxidative stress, and mitophagy

(2017) Rebecca J. Wilson et al.   MITOCHONDRION

Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening

(2017) Daniela M. Arduino et al.   MOLECULAR CELL

Hypoxia induces heart regeneration in adult mice

(2017) Yuji Nakada et al.   NATURE

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

(2017) Timothy S. Luongo et al.   NATURE

IRF3 and type I interferons fuel a fatal response to myocardial infarction

(2017) Kevin R King et al.   NATURE MEDICINE

Sarcoplasmic reticulum–mitochondria communication in cardiovascular pathophysiology

(2017) Camila Lopez-Crisosto et al.   Nature Reviews Cardiology

Myocardial stress and autophagy: mechanisms and potential therapies

(2017) Lea M. D. Delbridge et al.   Nature Reviews Cardiology

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Mitochondrial diseases: the contribution of organelle stress responses to pathology

(2017) Anu Suomalainen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases

(2017) Kathleen A. Hershberger et al.   Nature Reviews Nephrology

The immunology of atherosclerosis

(2017) Anton Gisterå et al.   Nature Reviews Nephrology

Chronic administration of mitochondrion-targeted peptide SS-31 prevents atherosclerotic development in ApoE knockout mice fed Western diet

(2017) Meng Zhang et al.   PLoS One

AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1

(2017) Traci L. Marin et al.   Science Signaling

Discovery of Highly Potent 2-Sulfonyl-Pyrimidinyl Derivatives for Apoptosis Inhibition and Ischemia Treatment

(2017) Li Li et al.   ACS Medicinal Chemistry Letters

MicroRNA in cardiovascular biology and disease

(2017) Anna Wojciechowska et al.   Advances in Clinical and Experimental Medicine

Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice

(2017) Aleksandr E. Vendrov et al.   Journal of the American Heart Association

Divergent Effects of miR‐181 Family Members on Myocardial Function Through Protective Cytosolic and Detrimental Mitochondrial microRNA Targets

(2017) Samarjit Das et al.   Journal of the American Heart Association

AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1

(2017) Traci L. Marin et al.   Science Signaling

Physiological Mitochondrial Fragmentation Is a Normal Cardiac Adaptation to Increased Energy Demand

(2017) Michael Coronado et al.   CIRCULATION RESEARCH

Administration of antioxidant peptide SS-31 attenuates transverse aortic constriction-induced pulmonary arterial hypertension in mice

(2016) Hung-i Lu et al.   ACTA PHARMACOLOGICA SINICA

Mitochondrial complex I-linked disease

(2016) Richard J. Rodenburg   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization

(2016) Wen Yang et al.   CELL

Involvement of mitochondrial permeability transition pore (mPTP) in cardiac arrhythmias: Evidence from cyclophilin D knockout mice

(2016) Richard Gordan et al.   CELL CALCIUM

Interplay of mitochondrial metabolism and microRNAs

(2016) Julian Geiger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload–Induced Mitochondrial Dysfunction and Heart FailureCLINICAL PERSPECTIVE

(2016) Akihiro Shirakabe et al.   CIRCULATION

MicroRNA-21 Lowers Blood Pressure in Spontaneous Hypertensive Rats by Upregulating Mitochondrial TranslationClinical Perspective

(2016) Huaping Li et al.   CIRCULATION

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart FailureCLINICAL PERSPECTIVE

(2016) Haipeng Sun et al.   CIRCULATION

Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome AcidificationCLINICAL PERSPECTIVE

(2016) Dan L. Li et al.   CIRCULATION

Lipid Use and Misuse by the Heart

(2016) P. Christian Schulze et al.   CIRCULATION RESEARCH

Mitochondrial Function, Biology, and Role in Disease

(2016) Elizabeth Murphy et al.   CIRCULATION RESEARCH

Poly(ADP-ribose) polymerase 1 deficiency increases nitric oxide production and attenuates aortic atherogenesis through downregulation of arginase II

(2016) Shu-jian Wei et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Emerging drugs for the treatment of angina pectoris

(2016) Cher-Rin Chong et al.   EXPERT OPINION ON EMERGING DRUGS

MicroRNA-2861 regulates programmed necrosis in cardiomyocyte by impairing adenine nucleotide translocase 1 expression

(2016) Kun Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Cyclophilin D in Vascular Oxidative Stress and HypertensionNovelty and Significance

(2016) Hana A. Itani et al.   HYPERTENSION

Caspases Connect Cell-Death Signaling to Organismal Homeostasis

(2016) Lorenzo Galluzzi et al.   IMMUNITY

miR-106a promotes cardiac hypertrophy by targeting mitofusin 2

(2016) Xiaoxiang Guan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Preservation of myocardial fatty acid oxidation prevents diastolic dysfunction in mice subjected to angiotensin II infusion

(2016) Yong Seon Choi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

α-MHC MitoTimer mouse: In vivo mitochondrial turnover model reveals remarkable mitochondrial heterogeneity in the heart

(2016) Aleksandr Stotland et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cyclosporine A in Reperfused Myocardial Infarction

(2016) Filippo Ottani et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway

(2016) Xian Jiang et al.   MOLECULAR CELL

Correcting mitochondrial fusion by manipulating mitofusin conformations

(2016) Antonietta Franco et al.   NATURE

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Inflammatory processes in cardiovascular disease: a route to targeted therapies

(2016) Neil Ruparelia et al.   Nature Reviews Cardiology

Advances in drug, ablation and device therapy for cardiac arrhythmias

(2016) Laurent Macle et al.   Nature Reviews Cardiology

Acute coronary syndromes in women and men

(2016) Neha J. Pagidipati et al.   Nature Reviews Cardiology

Mitochondrial function as a therapeutic target in heart failure

(2016) David A. Brown et al.   Nature Reviews Cardiology

Regulated necrosis: disease relevance and therapeutic opportunities

(2016) Marcus Conrad et al.   NATURE REVIEWS DRUG DISCOVERY

Necroptosis in development, inflammation and disease

(2016) Ricardo Weinlich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Six months of resveratrol supplementation has no measurable effect in type 2 diabetic patients. A randomized, double blind, placebo-controlled trial

(2016) S. Bo et al.   PHARMACOLOGICAL RESEARCH

Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function

(2016) Sushabhan Sadhukhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Permeability Transition: New Findings and Persisting Uncertainties

(2016) Valentina Izzo et al.   TRENDS IN CELL BIOLOGY

Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction

(2016) A R Hall et al.   Cell Death & Disease

CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation

(2016) Shangcheng Xu et al.   Nature Communications

Nanoparticle‐Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia‐Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction

(2016) Ayako Ishikita et al.   Journal of the American Heart Association

Restoration of Mitochondrial Cardiolipin Attenuates Cardiac Damage in Swine Renovascular Hypertension

(2016) Alfonso Eirin et al.   Journal of the American Heart Association

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

(2016) Angela V. Hafner et al.   Aging-US

Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis

(2016) Wei Lu et al.   PLoS One

Nanoparticle-Mediated Targeting of Cyclosporine A Enhances Cardioprotection Against Ischemia-Reperfusion Injury Through Inhibition of Mitochondrial Permeability Transition Pore Opening

(2016) Gentaro Ikeda et al.   Scientific Reports

The Sirt1 activator SRT1720 attenuates angiotensin II-induced atherosclerosis in apoE−/− mice through inhibiting vascular inflammatory response

(2015) Yi xi Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Puerarin prevents cardiac hypertrophy induced by pressure overload through activation of autophagy

(2015) Bei Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Effectiveness of Preoperative Trimetazidine on Myocardial Preservation in Coronary Artery Bypass Graft Patients: A Systematic Review and Meta-Analysis

(2015) Nan Zhang et al.   CARDIOLOGY

Gene therapy for cardiovascular disease: advances in vector development, targeting, and delivery for clinical translation

(2015) Melvin Y. Rincon et al.   CARDIOVASCULAR RESEARCH

MicroRNA-150 protects the mouse heart from ischaemic injury by regulating cell death

(2015) Yaoping Tang et al.   CARDIOVASCULAR RESEARCH

Circulating mitochondrial DNA and Toll-like receptor 9 are associated with vascular dysfunction in spontaneously hypertensive rats

(2015) Cameron G. McCarthy et al.   CARDIOVASCULAR RESEARCH

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

miR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation

(2015) Z Li et al.   CELL DEATH AND DIFFERENTIATION

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

Homocysteine andMTHFRMutations

(2015) Stephan Moll et al.   CIRCULATION

Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse HeartsNovelty and Significance

(2015) Moshi Song et al.   CIRCULATION RESEARCH

Mitochondrial Reprogramming Induced by CaMKII  Mediates Hypertrophy Decompensation

(2015) B. D. Westenbrink et al.   CIRCULATION RESEARCH

Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in AtherosclerosisNovelty and Significance

(2015) Denuja Karunakaran et al.   CIRCULATION RESEARCH

Translational Regulation of the Mitochondrial Genome Following Redistribution of Mitochondrial MicroRNA in the Diabetic HeartCLINICAL PERSPECTIVE

(2015) Rajaganapathi Jagannathan et al.   Circulation-Cardiovascular Genetics

Defective autophagy is a key feature of cerebral cavernous malformations

(2015) Saverio Marchi et al.   EMBO Molecular Medicine

EMBRACE STEMI study: a Phase 2a trial to evaluate the safety, tolerability, and efficacy of intravenous MTP-131 on reperfusion injury in patients undergoing primary percutaneous coronary intervention

(2015) C. Michael Gibson et al.   EUROPEAN HEART JOURNAL

Mitochondrial DNA-LL-37 Complex Promotes Atherosclerosis by Escaping from Autophagic Recognition

(2015) Zhiye Zhang et al.   IMMUNITY

Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure

(2015) Thomas J. Cahill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacologic Inhibition of the NLRP3 Inflammasome Preserves Cardiac Function After Ischemic and Nonischemic Injury in the Mouse

(2015) Carlo Marchetti et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Mitochondrial calcium and the regulation of metabolism in the heart

(2015) George S.B. Williams et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Rapamycin Promotes the Autophagic Degradation of Oxidized Low-Density Lipoprotein in Human Umbilical Vein Endothelial Cells

(2015) Yanlin Zhang et al.   JOURNAL OF VASCULAR RESEARCH

Bendavia restores mitochondrial energy metabolism gene expression and suppresses cardiac fibrosis in the border zone of the infarcted heart

(2015) Jianru Shi et al.   LIFE SCIENCES

Organelle-Specific Initiation of Autophagy

(2015) Valentina Sica et al.   MOLECULAR CELL

New medical therapies for heart failure

(2015) Thomas G. von Lueder et al.   Nature Reviews Cardiology

Coronary microvascular dysfunction: sex-specific risk, diagnosis and therapy

(2015) Jenna Dean et al.   Nature Reviews Cardiology

Inflammation and the pathogenesis of atrial fibrillation

(2015) Yu-Feng Hu et al.   Nature Reviews Cardiology

Anti-inflammatory therapies for atherosclerosis

(2015) Magnus Bäck et al.   Nature Reviews Cardiology

Cyclosporine before PCI in Patients with Acute Myocardial Infarction

(2015) Thien-Tri Cung et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Cardioprotective Effect of Vitamin E (Alpha-Tocopherol) Is Strongly Related to Age and Gender in Mice

(2015) Xiao-Xia Hu et al.   PLoS One

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart

(2015) Tyler P. Rasmussen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial calcium overload is a key determinant in heart failure

(2015) Gaetano Santulli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice

(2015) T. Wai et al.   SCIENCE

Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice

(2015) G. Gong et al.   SCIENCE

Altered expression of P2Y2 and P2X7 purinergic receptors in the isolated rat heart mediates ischemia–reperfusion injury

(2015) Miriam Granado et al.   VASCULAR PHARMACOLOGY

NFAT4-dependent miR-324-5p regulates mitochondrial morphology and cardiomyocyte cell death by targeting Mtfr1

(2015) K Wang et al.   Cell Death & Disease

Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure

(2015) San-Pin Wu et al.   Nature Communications

E2F1-dependent miR-421 regulates mitochondrial fragmentation and myocardial infarction by targeting Pink1

(2015) Kun Wang et al.   Nature Communications

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

(2015) Vinodkumar B. Pillai et al.   Nature Communications

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

(2015) Timothy S. Luongo et al.   Cell Reports

The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart

(2015) Jennifer Q. Kwong et al.   Cell Reports

Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart

(2015) Wenjing Xu et al.   Cell Reports

Translational Regulation of the Mitochondrial Genome Following Redistribution of Mitochondrial MicroRNA in the Diabetic HeartCLINICAL PERSPECTIVE

(2015) Rajaganapathi Jagannathan et al.   Circulation-Cardiovascular Genetics

Heart‐Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium

(2015) Claudia Kiermayer et al.   Journal of the American Heart Association

Improvement in Cardiac Energetics by Perhexiline in Heart Failure Due to Dilated Cardiomyopathy

(2015) Roger M. Beadle et al.   JACC-Heart Failure

A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis

(2015) James G. Krueger et al.   PLoS One

Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart

(2014) Dao-Fu Dai et al.   AGING CELL

E2F1-regulated miR-30b suppresses Cyclophilin D and protects heart from ischemia/reperfusion injury and necrotic cell death

(2014) K Wang et al.   CELL DEATH AND DIFFERENTIATION

Spermidine induces autophagy by inhibiting the acetyltransferase EP300

(2014) F Pietrocola et al.   CELL DEATH AND DIFFERENTIATION

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

(2014) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Myocardial Contractile Dysfunction Is Associated With Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but Not in Obese Patients

(2014) David Montaigne et al.   CIRCULATION

Histone Deacetylase Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy

(2014) Min Xie et al.   CIRCULATION

Inhibiting Mitochondrial Na + /Ca 2+ Exchange Prevents Sudden Death in a Guinea Pig Model of Heart Failure

(2014) Ting Liu et al.   CIRCULATION RESEARCH

Impaired In Vivo Mitochondrial Krebs Cycle Activity After Myocardial Infarction Assessed Using Hyperpolarized Magnetic Resonance Spectroscopy

(2014) Michael S. Dodd et al.   Circulation-Cardiovascular Imaging

Insights Into Metabolic Remodeling of the Hypertrophic and Failing Myocardium

(2014) Bradford G. Hill et al.   Circulation-Heart Failure

Metabolomic Analysis of Pressure-Overloaded and Infarcted Mouse Hearts

(2014) Brian E. Sansbury et al.   Circulation-Heart Failure

Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: MITOCARE study results

(2014) D. Atar et al.   EUROPEAN HEART JOURNAL

The effect of perhexiline on myocardial protection during coronary artery surgery: a two-centre, randomized, double-blind, placebo-controlled trial

(2014) N. E. Drury et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Multicentre double-blind randomized controlled trial of perhexiline as a metabolic modulator to augment myocardial protection in patients with left ventricular hypertrophy undergoing cardiac surgery

(2014) Eshan L. Senanayake et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Atg5 deficiency-mediated mitophagy aggravates cardiac inflammation and injury in response to angiotensin II

(2014) Wei Zhao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Atrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy

(2014) Tania Zaglia et al.   JOURNAL OF CLINICAL INVESTIGATION

Cinnamic Anilides as New Mitochondrial Permeability Transition Pore Inhibitors Endowed with Ischemia-Reperfusion Injury Protective Effect in Vivo

(2014) Daniele Fancelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Translation of TRO40303 from myocardial infarction models to demonstration of safety and tolerance in a randomized Phase I trial

(2014) Sophie Le Lamer et al.   Journal of Translational Medicine

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

(2014) Guillermo Mariño et al.   MOLECULAR CELL

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

Current and emerging strategies for the prevention of graft-versus-host disease

(2014) Sung Won Choi et al.   Nature Reviews Clinical Oncology

Mitochondrial dynamics and inheritance during cell division, development and disease

(2014) Prashant Mishra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pharmacogenetics and immunosuppressive drugs in solid organ transplantation

(2014) Teun van Gelder et al.   Nature Reviews Nephrology

Disturbed mitochondrial dynamics and neurodegenerative disorders

(2014) Florence Burté et al.   Nature Reviews Neurology

Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition

(2014) M Bonora et al.   ONCOGENE

miR-181c Regulates the Mitochondrial Genome, Bioenergetics, and Propensity for Heart Failure In Vivo

(2014) Samarjit Das et al.   PLoS One

Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion

(2014) Takanobu Yamamoto et al.   PLoS One

Impaired Autophagy Contributes to Adverse Cardiac Remodeling in Acute Myocardial Infarction

(2014) Xiaoqian Wu et al.   PLoS One

Doxorubicin-induced carbonylation and degradation of cardiac myosin binding protein C promote cardiotoxicity

(2014) Baikuntha Aryal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tubulin hyperacetylation is adaptive in cardiac proteotoxicity by promoting autophagy

(2014) Patrick M. McLendon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic control of cell death

(2014) D. R. Green et al.   SCIENCE

Molecular mechanisms of regulated necrosis

(2014) Lorenzo Galluzzi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner

(2014) Mohamed Elgendy et al.   Nature Communications

CaMKII inhibitors: from research tools to therapeutic agents

(2014) Patricia Pellicena et al.   Frontiers in Pharmacology

The Effect of Coenzyme Q 10 on Morbidity and Mortality in Chronic Heart Failure

(2014) Svend A. Mortensen et al.   JACC-Heart Failure

Calorie restriction can reverse, as well as prevent, aging cardiomyopathy

(2013) Lin Yan et al.   AGE

Mitophagy Is Required for Acute Cardioprotection by Simvastatin

(2013) Allen M. Andres et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxisome Proliferator-activated Receptor γ, Coactivator 1α Deletion Induces Angiotensin II–Associated Vascular Dysfunction by Increasing Mitochondrial Oxidative Stress and Vascular Inflammation

(2013) Swenja Kröller-Schön et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

(2013) Hazel H Szeto   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of apoptosis by the intrinsic but not the extrinsic apoptotic pathway in myocardial ischemia-reperfusion

(2013) Arnt V. Kristen et al.   CARDIOVASCULAR PATHOLOGY

The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury

(2013) Øystein Sandanger et al.   CARDIOVASCULAR RESEARCH

Role of the c subunit of the FOATP synthase in mitochondrial permeability transition

(2013) Massimo Bonora et al.   CELL CYCLE

Mitochondrial Contagion Induced by Parkin Deficiency in Drosophila Hearts and Its Containment by Suppressing Mitofusin

(2013) Poonam Bhandari et al.   CIRCULATION RESEARCH

Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission

(2013) Willard W. Sharp et al.   FASEB JOURNAL

miR-761 regulates the mitochondrial network by targeting mitochondrial fission factor

(2013) Bo Long et al.   FREE RADICAL BIOLOGY AND MEDICINE

The breathing heart — Mitochondrial respiratory chain dysfunction in cardiac disease

(2013) Konstantin Schwarz et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia–Reperfusion in the Mouse

(2013) Carlo Marchetti et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Reduction of Early Reperfusion Injury With the Mitochondria-Targeting Peptide Bendavia

(2013) David A. Brown et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Enhanced autophagy ameliorates cardiac proteinopathy

(2013) Md. Shenuarin Bhuiyan et al.   JOURNAL OF CLINICAL INVESTIGATION

NCLX: The mitochondrial sodium calcium exchanger

(2013) Liron Boyman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress

(2013) Sadhana A. Samant et al.   MOLECULAR AND CELLULAR BIOLOGY

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter

(2013) Xin Pan et al.   NATURE CELL BIOLOGY

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2

(2013) Yasuhiro Maejima et al.   NATURE MEDICINE

New concepts in the design of drug-eluting coronary stents

(2013) Scot Garg et al.   Nature Reviews Cardiology

Pharmacological approaches to restore mitochondrial function

(2013) Pénélope A. Andreux et al.   NATURE REVIEWS DRUG DISCOVERY

Dynasore Protects Mitochondria and Improves Cardiac Lusitropy in Langendorff Perfused Mouse Heart

(2013) Danchen Gao et al.   PLoS One

Attenuation of Doxorubicin-Induced Cardiotoxicity by mdivi-1: A Mitochondrial Division/Mitophagy Inhibitor

(2013) Mayel Gharanei et al.   PLoS One

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

NKG2D Blockade Significantly Attenuates Ischemia-Reperfusion Injury in a Cardiac Transplantation Model

(2013) B. Shen et al.   TRANSPLANTATION PROCEEDINGS

Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart

(2013) Atsushi Hoshino et al.   Nature Communications

Acute Inhibition of Excessive Mitochondrial Fission After Myocardial Infarction Prevents Long‐term Cardiac Dysfunction

(2013) Marie‐Hélène Disatnik et al.   Journal of the American Heart Association

Rationale and Design of the ‘MITOCARE’ Study: A Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of TRO40303 for the Reduction of Reperfusion Injury in Patients Undergoing Percutaneous Coronary Intervention for Acute Myocardial Infarction

(2012) MITOCARE Study Group   CARDIOLOGY

Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload

(2012) Jerome Piquereau et al.   CARDIOVASCULAR RESEARCH

NecroX-5 prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter

(2012) Vu Thi Thu et al.   CARDIOVASCULAR RESEARCH

Autophagy Links Inflammasomes to Atherosclerotic Progression

(2012) Babak Razani et al.   Cell Metabolism

Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis

(2012) Xianghai Liao et al.   Cell Metabolism

Rheb is a Critical Regulator of Autophagy During Myocardial Ischemia

(2012) Sebastiano Sciarretta et al.   CIRCULATION

Mitochondrial Control of Cellular Life, Stress, and Death

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