Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles
出版年份 2018 全文链接
标题
Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles
作者
关键词
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出版物
Nature Reviews Cardiology
Volume -, Issue -, Pages -
出版商
Springer Nature America, Inc
发表日期
2018-09-03
DOI
10.1038/s41569-018-0074-0
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- SnapShot: CGAS-STING Signaling
- (2018) Lorenzo Galluzzi et al. CELL
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- (2018) Lorenzo Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- Cytosolic DNA Sensing Promotes Macrophage Transformation and Governs Myocardial Ischemic Injury
- (2018) Dian J. Cao et al. CIRCULATION
- Beneficial effects of acute trans-resveratrol supplementation in treated hypertensive patients with endothelial dysfunction
- (2018) B.C.A.A Marques et al. CLINICAL AND EXPERIMENTAL HYPERTENSION
- MitoQ improves mitochondrial dysfunction in heart failure induced by pressure overload
- (2018) Rogério Faustino Ribeiro Junior et al. FREE RADICAL BIOLOGY AND MEDICINE
- Building and decoding ubiquitin chains for mitophagy
- (2018) J. Wade Harper et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Aspirin Recapitulates Features of Caloric Restriction
- (2018) Federico Pietrocola et al. Cell Reports
- P6486The integration of AKI and an elevation in plasma level of high sensitivity cardiac troponin T after PCI predicted more major cardiovascular events in acute coronary syndrome patients
- (2017) L. Luo et al. EUROPEAN HEART JOURNAL
- Extracellular nucleosides and nucleotides as immunomodulators
- (2017) Oliver Kepp et al. IMMUNOLOGICAL REVIEWS
- Short-term administration of Nicotinamide Mononucleotide preserves cardiac mitochondrial homeostasis and prevents heart failure
- (2017) Rongli Zhang et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension
- (2017) Lian Tian et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Moderate therapeutic hypothermia induces multimodal protective effects in oxygen-glucose deprivation/reperfusion injured cardiomyocytes
- (2017) Jana Krech et al. MITOCHONDRION
- Conditional MitoTimer reporter mice for assessment of mitochondrial structure, oxidative stress, and mitophagy
- (2017) Rebecca J. Wilson et al. MITOCHONDRION
- Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening
- (2017) Daniela M. Arduino et al. MOLECULAR CELL
- Hypoxia induces heart regeneration in adult mice
- (2017) Yuji Nakada et al. NATURE
- The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability
- (2017) Timothy S. Luongo et al. NATURE
- IRF3 and type I interferons fuel a fatal response to myocardial infarction
- (2017) Kevin R King et al. NATURE MEDICINE
- Sarcoplasmic reticulum–mitochondria communication in cardiovascular pathophysiology
- (2017) Camila Lopez-Crisosto et al. Nature Reviews Cardiology
- Myocardial stress and autophagy: mechanisms and potential therapies
- (2017) Lea M. D. Delbridge et al. Nature Reviews Cardiology
- Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
- (2017) Lorenzo Galluzzi et al. NATURE REVIEWS DRUG DISCOVERY
- Mitochondrial diseases: the contribution of organelle stress responses to pathology
- (2017) Anu Suomalainen et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases
- (2017) Kathleen A. Hershberger et al. Nature Reviews Nephrology
- The immunology of atherosclerosis
- (2017) Anton Gisterå et al. Nature Reviews Nephrology
- Chronic administration of mitochondrion-targeted peptide SS-31 prevents atherosclerotic development in ApoE knockout mice fed Western diet
- (2017) Meng Zhang et al. PLoS One
- AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1
- (2017) Traci L. Marin et al. Science Signaling
- Discovery of Highly Potent 2-Sulfonyl-Pyrimidinyl Derivatives for Apoptosis Inhibition and Ischemia Treatment
- (2017) Li Li et al. ACS Medicinal Chemistry Letters
- MicroRNA in cardiovascular biology and disease
- (2017) Anna Wojciechowska et al. Advances in Clinical and Experimental Medicine
- Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice
- (2017) Aleksandr E. Vendrov et al. Journal of the American Heart Association
- Divergent Effects of miR‐181 Family Members on Myocardial Function Through Protective Cytosolic and Detrimental Mitochondrial microRNA Targets
- (2017) Samarjit Das et al. Journal of the American Heart Association
- AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1
- (2017) Traci L. Marin et al. Science Signaling
- Physiological Mitochondrial Fragmentation Is a Normal Cardiac Adaptation to Increased Energy Demand
- (2017) Michael Coronado et al. CIRCULATION RESEARCH
- Administration of antioxidant peptide SS-31 attenuates transverse aortic constriction-induced pulmonary arterial hypertension in mice
- (2016) Hung-i Lu et al. ACTA PHARMACOLOGICA SINICA
- Mitochondrial complex I-linked disease
- (2016) Richard J. Rodenburg BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization
- (2016) Wen Yang et al. CELL
- Involvement of mitochondrial permeability transition pore (mPTP) in cardiac arrhythmias: Evidence from cyclophilin D knockout mice
- (2016) Richard Gordan et al. CELL CALCIUM
- Interplay of mitochondrial metabolism and microRNAs
- (2016) Julian Geiger et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload–Induced Mitochondrial Dysfunction and Heart FailureCLINICAL PERSPECTIVE
- (2016) Akihiro Shirakabe et al. CIRCULATION
- MicroRNA-21 Lowers Blood Pressure in Spontaneous Hypertensive Rats by Upregulating Mitochondrial TranslationClinical Perspective
- (2016) Huaping Li et al. CIRCULATION
- Catabolic Defect of Branched-Chain Amino Acids Promotes Heart FailureCLINICAL PERSPECTIVE
- (2016) Haipeng Sun et al. CIRCULATION
- Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome AcidificationCLINICAL PERSPECTIVE
- (2016) Dan L. Li et al. CIRCULATION
- Lipid Use and Misuse by the Heart
- (2016) P. Christian Schulze et al. CIRCULATION RESEARCH
- Mitochondrial Function, Biology, and Role in Disease
- (2016) Elizabeth Murphy et al. CIRCULATION RESEARCH
- Poly(ADP-ribose) polymerase 1 deficiency increases nitric oxide production and attenuates aortic atherogenesis through downregulation of arginase II
- (2016) Shu-jian Wei et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Emerging drugs for the treatment of angina pectoris
- (2016) Cher-Rin Chong et al. EXPERT OPINION ON EMERGING DRUGS
- MicroRNA-2861 regulates programmed necrosis in cardiomyocyte by impairing adenine nucleotide translocase 1 expression
- (2016) Kun Wang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Mitochondrial Cyclophilin D in Vascular Oxidative Stress and HypertensionNovelty and Significance
- (2016) Hana A. Itani et al. HYPERTENSION
- Caspases Connect Cell-Death Signaling to Organismal Homeostasis
- (2016) Lorenzo Galluzzi et al. IMMUNITY
- miR-106a promotes cardiac hypertrophy by targeting mitofusin 2
- (2016) Xiaoxiang Guan et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Preservation of myocardial fatty acid oxidation prevents diastolic dysfunction in mice subjected to angiotensin II infusion
- (2016) Yong Seon Choi et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- α-MHC MitoTimer mouse: In vivo mitochondrial turnover model reveals remarkable mitochondrial heterogeneity in the heart
- (2016) Aleksandr Stotland et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Cyclosporine A in Reperfused Myocardial Infarction
- (2016) Filippo Ottani et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway
- (2016) Xian Jiang et al. MOLECULAR CELL
- Correcting mitochondrial fusion by manipulating mitofusin conformations
- (2016) Antonietta Franco et al. NATURE
- CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis
- (2016) Ting Zhang et al. NATURE MEDICINE
- Cardioprotection and lifespan extension by the natural polyamine spermidine
- (2016) Tobias Eisenberg et al. NATURE MEDICINE
- Inflammatory processes in cardiovascular disease: a route to targeted therapies
- (2016) Neil Ruparelia et al. Nature Reviews Cardiology
- Advances in drug, ablation and device therapy for cardiac arrhythmias
- (2016) Laurent Macle et al. Nature Reviews Cardiology
- Acute coronary syndromes in women and men
- (2016) Neha J. Pagidipati et al. Nature Reviews Cardiology
- Mitochondrial function as a therapeutic target in heart failure
- (2016) David A. Brown et al. Nature Reviews Cardiology
- Regulated necrosis: disease relevance and therapeutic opportunities
- (2016) Marcus Conrad et al. NATURE REVIEWS DRUG DISCOVERY
- Necroptosis in development, inflammation and disease
- (2016) Ricardo Weinlich et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
- (2016) Michael S. Bonkowski et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Six months of resveratrol supplementation has no measurable effect in type 2 diabetic patients. A randomized, double blind, placebo-controlled trial
- (2016) S. Bo et al. PHARMACOLOGICAL RESEARCH
- Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function
- (2016) Sushabhan Sadhukhan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial Permeability Transition: New Findings and Persisting Uncertainties
- (2016) Valentina Izzo et al. TRENDS IN CELL BIOLOGY
- Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction
- (2016) A R Hall et al. Cell Death & Disease
- CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation
- (2016) Shangcheng Xu et al. Nature Communications
- Nanoparticle‐Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia‐Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction
- (2016) Ayako Ishikita et al. Journal of the American Heart Association
- Restoration of Mitochondrial Cardiolipin Attenuates Cardiac Damage in Swine Renovascular Hypertension
- (2016) Alfonso Eirin et al. Journal of the American Heart Association
- Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy
- (2016) Angela V. Hafner et al. Aging-US
- Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis
- (2016) Wei Lu et al. PLoS One
- Nanoparticle-Mediated Targeting of Cyclosporine A Enhances Cardioprotection Against Ischemia-Reperfusion Injury Through Inhibition of Mitochondrial Permeability Transition Pore Opening
- (2016) Gentaro Ikeda et al. Scientific Reports
- The Sirt1 activator SRT1720 attenuates angiotensin II-induced atherosclerosis in apoE−/− mice through inhibiting vascular inflammatory response
- (2015) Yi xi Chen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Puerarin prevents cardiac hypertrophy induced by pressure overload through activation of autophagy
- (2015) Bei Liu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Effectiveness of Preoperative Trimetazidine on Myocardial Preservation in Coronary Artery Bypass Graft Patients: A Systematic Review and Meta-Analysis
- (2015) Nan Zhang et al. CARDIOLOGY
- Gene therapy for cardiovascular disease: advances in vector development, targeting, and delivery for clinical translation
- (2015) Melvin Y. Rincon et al. CARDIOVASCULAR RESEARCH
- MicroRNA-150 protects the mouse heart from ischaemic injury by regulating cell death
- (2015) Yaoping Tang et al. CARDIOVASCULAR RESEARCH
- Circulating mitochondrial DNA and Toll-like receptor 9 are associated with vascular dysfunction in spontaneously hypertensive rats
- (2015) Cameron G. McCarthy et al. CARDIOVASCULAR RESEARCH
- Mitochondrial ROS Signaling in Organismal Homeostasis
- (2015) Gerald S. Shadel et al. CELL
- miR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation
- (2015) Z Li et al. CELL DEATH AND DIFFERENTIATION
- Acetyl Coenzyme A: A Central Metabolite and Second Messenger
- (2015) Federico Pietrocola et al. Cell Metabolism
- Homocysteine andMTHFRMutations
- (2015) Stephan Moll et al. CIRCULATION
- Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse HeartsNovelty and Significance
- (2015) Moshi Song et al. CIRCULATION RESEARCH
- Mitochondrial Reprogramming Induced by CaMKII Mediates Hypertrophy Decompensation
- (2015) B. D. Westenbrink et al. CIRCULATION RESEARCH
- Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in AtherosclerosisNovelty and Significance
- (2015) Denuja Karunakaran et al. CIRCULATION RESEARCH
- Translational Regulation of the Mitochondrial Genome Following Redistribution of Mitochondrial MicroRNA in the Diabetic HeartCLINICAL PERSPECTIVE
- (2015) Rajaganapathi Jagannathan et al. Circulation-Cardiovascular Genetics
- Defective autophagy is a key feature of cerebral cavernous malformations
- (2015) Saverio Marchi et al. EMBO Molecular Medicine
- EMBRACE STEMI study: a Phase 2a trial to evaluate the safety, tolerability, and efficacy of intravenous MTP-131 on reperfusion injury in patients undergoing primary percutaneous coronary intervention
- (2015) C. Michael Gibson et al. EUROPEAN HEART JOURNAL
- Mitochondrial DNA-LL-37 Complex Promotes Atherosclerosis by Escaping from Autophagic Recognition
- (2015) Zhiye Zhang et al. IMMUNITY
- Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure
- (2015) Thomas J. Cahill et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pharmacologic Inhibition of the NLRP3 Inflammasome Preserves Cardiac Function After Ischemic and Nonischemic Injury in the Mouse
- (2015) Carlo Marchetti et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Mitochondrial calcium and the regulation of metabolism in the heart
- (2015) George S.B. Williams et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Rapamycin Promotes the Autophagic Degradation of Oxidized Low-Density Lipoprotein in Human Umbilical Vein Endothelial Cells
- (2015) Yanlin Zhang et al. JOURNAL OF VASCULAR RESEARCH
- Bendavia restores mitochondrial energy metabolism gene expression and suppresses cardiac fibrosis in the border zone of the infarcted heart
- (2015) Jianru Shi et al. LIFE SCIENCES
- Organelle-Specific Initiation of Autophagy
- (2015) Valentina Sica et al. MOLECULAR CELL
- New medical therapies for heart failure
- (2015) Thomas G. von Lueder et al. Nature Reviews Cardiology
- Coronary microvascular dysfunction: sex-specific risk, diagnosis and therapy
- (2015) Jenna Dean et al. Nature Reviews Cardiology
- Inflammation and the pathogenesis of atrial fibrillation
- (2015) Yu-Feng Hu et al. Nature Reviews Cardiology
- Anti-inflammatory therapies for atherosclerosis
- (2015) Magnus Bäck et al. Nature Reviews Cardiology
- Cyclosporine before PCI in Patients with Acute Myocardial Infarction
- (2015) Thien-Tri Cung et al. NEW ENGLAND JOURNAL OF MEDICINE
- The Cardioprotective Effect of Vitamin E (Alpha-Tocopherol) Is Strongly Related to Age and Gender in Mice
- (2015) Xiao-Xia Hu et al. PLoS One
- Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart
- (2015) Tyler P. Rasmussen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial calcium overload is a key determinant in heart failure
- (2015) Gaetano Santulli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice
- (2015) T. Wai et al. SCIENCE
- Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice
- (2015) G. Gong et al. SCIENCE
- Altered expression of P2Y2 and P2X7 purinergic receptors in the isolated rat heart mediates ischemia–reperfusion injury
- (2015) Miriam Granado et al. VASCULAR PHARMACOLOGY
- NFAT4-dependent miR-324-5p regulates mitochondrial morphology and cardiomyocyte cell death by targeting Mtfr1
- (2015) K Wang et al. Cell Death & Disease
- Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure
- (2015) San-Pin Wu et al. Nature Communications
- E2F1-dependent miR-421 regulates mitochondrial fragmentation and myocardial infarction by targeting Pink1
- (2015) Kun Wang et al. Nature Communications
- Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3
- (2015) Vinodkumar B. Pillai et al. Nature Communications
- The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition
- (2015) Timothy S. Luongo et al. Cell Reports
- The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart
- (2015) Jennifer Q. Kwong et al. Cell Reports
- Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart
- (2015) Wenjing Xu et al. Cell Reports
- Translational Regulation of the Mitochondrial Genome Following Redistribution of Mitochondrial MicroRNA in the Diabetic HeartCLINICAL PERSPECTIVE
- (2015) Rajaganapathi Jagannathan et al. Circulation-Cardiovascular Genetics
- Heart‐Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium
- (2015) Claudia Kiermayer et al. Journal of the American Heart Association
- Improvement in Cardiac Energetics by Perhexiline in Heart Failure Due to Dilated Cardiomyopathy
- (2015) Roger M. Beadle et al. JACC-Heart Failure
- A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis
- (2015) James G. Krueger et al. PLoS One
- Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart
- (2014) Dao-Fu Dai et al. AGING CELL
- E2F1-regulated miR-30b suppresses Cyclophilin D and protects heart from ischemia/reperfusion injury and necrotic cell death
- (2014) K Wang et al. CELL DEATH AND DIFFERENTIATION
- Spermidine induces autophagy by inhibiting the acetyltransferase EP300
- (2014) F Pietrocola et al. CELL DEATH AND DIFFERENTIATION
- Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
- (2014) L Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- Myocardial Contractile Dysfunction Is Associated With Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but Not in Obese Patients
- (2014) David Montaigne et al. CIRCULATION
- Histone Deacetylase Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy
- (2014) Min Xie et al. CIRCULATION
- Inhibiting Mitochondrial Na + /Ca 2+ Exchange Prevents Sudden Death in a Guinea Pig Model of Heart Failure
- (2014) Ting Liu et al. CIRCULATION RESEARCH
- Impaired In Vivo Mitochondrial Krebs Cycle Activity After Myocardial Infarction Assessed Using Hyperpolarized Magnetic Resonance Spectroscopy
- (2014) Michael S. Dodd et al. Circulation-Cardiovascular Imaging
- Insights Into Metabolic Remodeling of the Hypertrophic and Failing Myocardium
- (2014) Bradford G. Hill et al. Circulation-Heart Failure
- Metabolomic Analysis of Pressure-Overloaded and Infarcted Mouse Hearts
- (2014) Brian E. Sansbury et al. Circulation-Heart Failure
- Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: MITOCARE study results
- (2014) D. Atar et al. EUROPEAN HEART JOURNAL
- The effect of perhexiline on myocardial protection during coronary artery surgery: a two-centre, randomized, double-blind, placebo-controlled trial
- (2014) N. E. Drury et al. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
- Multicentre double-blind randomized controlled trial of perhexiline as a metabolic modulator to augment myocardial protection in patients with left ventricular hypertrophy undergoing cardiac surgery
- (2014) Eshan L. Senanayake et al. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
- Atg5 deficiency-mediated mitophagy aggravates cardiac inflammation and injury in response to angiotensin II
- (2014) Wei Zhao et al. FREE RADICAL BIOLOGY AND MEDICINE
- Atrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy
- (2014) Tania Zaglia et al. JOURNAL OF CLINICAL INVESTIGATION
- Cinnamic Anilides as New Mitochondrial Permeability Transition Pore Inhibitors Endowed with Ischemia-Reperfusion Injury Protective Effect in Vivo
- (2014) Daniele Fancelli et al. JOURNAL OF MEDICINAL CHEMISTRY
- Translation of TRO40303 from myocardial infarction models to demonstration of safety and tolerance in a randomized Phase I trial
- (2014) Sophie Le Lamer et al. Journal of Translational Medicine
- Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A
- (2014) Guillermo Mariño et al. MOLECULAR CELL
- Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
- (2014) Edward T. Chouchani et al. NATURE
- Cargo recognition and trafficking in selective autophagy
- (2014) Alexandra Stolz et al. NATURE CELL BIOLOGY
- Current and emerging strategies for the prevention of graft-versus-host disease
- (2014) Sung Won Choi et al. Nature Reviews Clinical Oncology
- Mitochondrial dynamics and inheritance during cell division, development and disease
- (2014) Prashant Mishra et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Pharmacogenetics and immunosuppressive drugs in solid organ transplantation
- (2014) Teun van Gelder et al. Nature Reviews Nephrology
- Disturbed mitochondrial dynamics and neurodegenerative disorders
- (2014) Florence Burté et al. Nature Reviews Neurology
- Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition
- (2014) M Bonora et al. ONCOGENE
- miR-181c Regulates the Mitochondrial Genome, Bioenergetics, and Propensity for Heart Failure In Vivo
- (2014) Samarjit Das et al. PLoS One
- Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion
- (2014) Takanobu Yamamoto et al. PLoS One
- Impaired Autophagy Contributes to Adverse Cardiac Remodeling in Acute Myocardial Infarction
- (2014) Xiaoqian Wu et al. PLoS One
- Doxorubicin-induced carbonylation and degradation of cardiac myosin binding protein C promote cardiotoxicity
- (2014) Baikuntha Aryal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tubulin hyperacetylation is adaptive in cardiac proteotoxicity by promoting autophagy
- (2014) Patrick M. McLendon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metabolic control of cell death
- (2014) D. R. Green et al. SCIENCE
- Molecular mechanisms of regulated necrosis
- (2014) Lorenzo Galluzzi et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner
- (2014) Mohamed Elgendy et al. Nature Communications
- CaMKII inhibitors: from research tools to therapeutic agents
- (2014) Patricia Pellicena et al. Frontiers in Pharmacology
- The Effect of Coenzyme Q 10 on Morbidity and Mortality in Chronic Heart Failure
- (2014) Svend A. Mortensen et al. JACC-Heart Failure
- Calorie restriction can reverse, as well as prevent, aging cardiomyopathy
- (2013) Lin Yan et al. AGE
- Mitophagy Is Required for Acute Cardioprotection by Simvastatin
- (2013) Allen M. Andres et al. ANTIOXIDANTS & REDOX SIGNALING
- Peroxisome Proliferator-activated Receptor γ, Coactivator 1α Deletion Induces Angiotensin II–Associated Vascular Dysfunction by Increasing Mitochondrial Oxidative Stress and Vascular Inflammation
- (2013) Swenja Kröller-Schön et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics
- (2013) Hazel H Szeto BRITISH JOURNAL OF PHARMACOLOGY
- Inhibition of apoptosis by the intrinsic but not the extrinsic apoptotic pathway in myocardial ischemia-reperfusion
- (2013) Arnt V. Kristen et al. CARDIOVASCULAR PATHOLOGY
- The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury
- (2013) Øystein Sandanger et al. CARDIOVASCULAR RESEARCH
- Role of the c subunit of the FOATP synthase in mitochondrial permeability transition
- (2013) Massimo Bonora et al. CELL CYCLE
- Mitochondrial Contagion Induced by Parkin Deficiency in Drosophila Hearts and Its Containment by Suppressing Mitofusin
- (2013) Poonam Bhandari et al. CIRCULATION RESEARCH
- Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission
- (2013) Willard W. Sharp et al. FASEB JOURNAL
- miR-761 regulates the mitochondrial network by targeting mitochondrial fission factor
- (2013) Bo Long et al. FREE RADICAL BIOLOGY AND MEDICINE
- The breathing heart — Mitochondrial respiratory chain dysfunction in cardiac disease
- (2013) Konstantin Schwarz et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia–Reperfusion in the Mouse
- (2013) Carlo Marchetti et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Reduction of Early Reperfusion Injury With the Mitochondria-Targeting Peptide Bendavia
- (2013) David A. Brown et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
- Enhanced autophagy ameliorates cardiac proteinopathy
- (2013) Md. Shenuarin Bhuiyan et al. JOURNAL OF CLINICAL INVESTIGATION
- NCLX: The mitochondrial sodium calcium exchanger
- (2013) Liron Boyman et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress
- (2013) Sadhana A. Samant et al. MOLECULAR AND CELLULAR BIOLOGY
- The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter
- (2013) Xin Pan et al. NATURE CELL BIOLOGY
- Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
- (2013) Robert A Koeth et al. NATURE MEDICINE
- Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2
- (2013) Yasuhiro Maejima et al. NATURE MEDICINE
- New concepts in the design of drug-eluting coronary stents
- (2013) Scot Garg et al. Nature Reviews Cardiology
- Pharmacological approaches to restore mitochondrial function
- (2013) Pénélope A. Andreux et al. NATURE REVIEWS DRUG DISCOVERY
- Dynasore Protects Mitochondria and Improves Cardiac Lusitropy in Langendorff Perfused Mouse Heart
- (2013) Danchen Gao et al. PLoS One
- Attenuation of Doxorubicin-Induced Cardiotoxicity by mdivi-1: A Mitochondrial Division/Mitophagy Inhibitor
- (2013) Mayel Gharanei et al. PLoS One
- PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria
- (2013) Y. Chen et al. SCIENCE
- NKG2D Blockade Significantly Attenuates Ischemia-Reperfusion Injury in a Cardiac Transplantation Model
- (2013) B. Shen et al. TRANSPLANTATION PROCEEDINGS
- Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart
- (2013) Atsushi Hoshino et al. Nature Communications
- Acute Inhibition of Excessive Mitochondrial Fission After Myocardial Infarction Prevents Long‐term Cardiac Dysfunction
- (2013) Marie‐Hélène Disatnik et al. Journal of the American Heart Association
- Rationale and Design of the MITOCARE Study: A Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of TRO40303 for the Reduction of Reperfusion Injury in Patients Undergoing Percutaneous Coronary Intervention for Acute Myocardial Infarction
- (2012) MITOCARE Study Group CARDIOLOGY
- Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload
- (2012) Jerome Piquereau et al. CARDIOVASCULAR RESEARCH
- NecroX-5 prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter
- (2012) Vu Thi Thu et al. CARDIOVASCULAR RESEARCH
- Autophagy Links Inflammasomes to Atherosclerotic Progression
- (2012) Babak Razani et al. Cell Metabolism
- Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis
- (2012) Xianghai Liao et al. Cell Metabolism
- Rheb is a Critical Regulator of Autophagy During Myocardial Ischemia
- (2012) Sebastiano Sciarretta et al. CIRCULATION
- Mitochondrial Control of Cellular Life, Stress, and Death
- (2012) Lorenzo Galluzzi et al. CIRCULATION RESEARCH
- Targeting cell death in the reperfused heart: Pharmacological approaches for cardioprotection
- (2012) Martinus I.F.J. Oerlemans et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Effect of Adenosine-Regulating Agent Acadesine on Morbidity and Mortality Associated With Coronary Artery Bypass Grafting
- (2012) Mark F. Newman et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Mitochondrial permeability transition in the diabetic heart: Contributions of thiol redox state and mitochondrial calcium to augmented reperfusion injury
- (2012) Ruben C. Sloan et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome
- (2012) Xiaoke Yin et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Ablation of ALCAT1 Mitigates Hypertrophic Cardiomyopathy through Effects on Oxidative Stress and Mitophagy
- (2012) X. Liu et al. MOLECULAR AND CELLULAR BIOLOGY
- Physiological Roles of Mitochondrial Reactive Oxygen Species
- (2012) Laura A. Sena et al. MOLECULAR CELL
- CaMKII determines mitochondrial stress responses in heart
- (2012) Mei-ling A. Joiner et al. NATURE
- Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
- (2012) Takafumi Oka et al. NATURE
- The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun
- (2012) Nagalingam R Sundaresan et al. NATURE MEDICINE
- Inherited calcium channelopathies in the pathophysiology of arrhythmias
- (2012) Luigi Venetucci et al. Nature Reviews Cardiology
- Altered sarcoplasmic reticulum calcium cycling—targets for heart failure therapy
- (2012) Changwon Kho et al. Nature Reviews Cardiology
- Sirtuins as regulators of metabolism and healthspan
- (2012) Riekelt H. Houtkooper et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Mitochondria: master regulators of danger signalling
- (2012) Lorenzo Galluzzi et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Mitochondrial division/mitophagy inhibitor (Mdivi) Ameliorates Pressure Overload Induced Heart Failure
- (2012) Srikanth Givvimani et al. PLoS One
- A Common Missense Variant in the ATP Receptor P2X7 Is Associated with Reduced Risk of Cardiovascular Events
- (2012) Olof Gidlöf et al. PLoS One
- The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy
- (2012) Ahmet Ucar et al. Nature Communications
- Autophagy limits acute myocardial infarction induced by permanent coronary artery occlusion
- (2011) Hiromitsu Kanamori et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- SIRT1-mediated acute cardioprotection
- (2011) Sergiy M. Nadtochiy et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Mitochondrial Fusion is Essential for Organelle Function and Cardiac Homeostasis
- (2011) Yun Chen et al. CIRCULATION RESEARCH
- The Role of Comorbidities in Cardioprotection
- (2011) Michael N. Sack et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
- Cardiolipin Binds to CD1d and Stimulates CD1d-Restricted T Cells in the Normal Murine Repertoire
- (2011) M. Dieude et al. JOURNAL OF IMMUNOLOGY
- p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia
- (2011) Atsushi Hoshino et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Oxidation of Myofibrillar Proteins in Human Heart Failure
- (2011) Marcella Canton et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy
- (2011) Dao-Fu Dai et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Mitofusin-2 Maintains Mitochondrial Structure and Contributes to Stress-Induced Permeability Transition in Cardiac Myocytes
- (2011) K. N. Papanicolaou et al. MOLECULAR AND CELLULAR BIOLOGY
- Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
- (2011) Joshua M. Baughman et al. NATURE
- A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter
- (2011) Diego De Stefani et al. NATURE
- Trimetazidine improves exercise performance in patients with peripheral arterial disease
- (2011) Cristiana Vitale et al. PHARMACOLOGICAL RESEARCH
- Preconditioning Involves Selective Mitophagy Mediated by Parkin and p62/SQSTM1
- (2011) Chengqun Huang et al. PLoS One
- PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function
- (2011) F. Billia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging
- (2011) D. R. Green et al. SCIENCE
- Inhibition of autophagy in the heart induces age-related cardiomyopathy
- (2010) Manabu Taneike et al. Autophagy
- Expression of mitochondrial fusion–fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition
- (2010) Sabzali Javadov et al. BASIC RESEARCH IN CARDIOLOGY
- Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury
- (2010) Sang-Bing Ong et al. CIRCULATION
- Metabolic Modulator Perhexiline Corrects Energy Deficiency and Improves Exercise Capacity in Symptomatic Hypertrophic Cardiomyopathy
- (2010) Khalid Abozguia et al. CIRCULATION
- Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes
- (2010) Nirmala Hariharan et al. CIRCULATION RESEARCH
- Mitofusin 2 Inhibits Angiotensin II-Induced Myocardial Hypertrophy
- (2010) Haiyi Yu et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
- TRO40303, a New Cardioprotective Compound, Inhibits Mitochondrial Permeability Transition
- (2010) S. Schaller et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
- (2010) Peter Duewell et al. NATURE
- Circulating mitochondrial DAMPs cause inflammatory responses to injury
- (2010) Qin Zhang et al. NATURE
- miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1
- (2010) Jian-Xun Wang et al. NATURE MEDICINE
- Mitochondrial protein import: from proteomics to functional mechanisms
- (2010) Oliver Schmidt et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Mitochondrial Pruning by Nix and BNip3: An Essential Function for Cardiac-Expressed Death Factors
- (2010) Gerald W. Dorn Journal of Cardiovascular Translational Research
- Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy
- (2009) M. Sulaiman et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Mitochondrial OPA1, apoptosis, and heart failure
- (2009) Le Chen et al. CARDIOVASCULAR RESEARCH
- Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery
- (2009) B Zhivotovsky et al. CELL DEATH AND DIFFERENTIATION
- Activation of a HIF1α-PPARγ Axis Underlies the Integration of Glycolytic and Lipid Anabolic Pathways in Pathologic Cardiac Hypertrophy
- (2009) Jaya Krishnan et al. Cell Metabolism
- Interleukin-1 Regulates Multiple Atherogenic Mechanisms in Response to Fat Feeding
- (2009) Janet Chamberlain et al. PLoS One
- A Mitochondria-Targeted Triphenylphosphonium-Conjugated Nitroxide Functions as a Radioprotector/Mitigator
- (2009) Jianfei Jiang et al. RADIATION RESEARCH
- No death without life: vital functions of apoptotic effectors
- (2008) L Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- Mitochondria-Penetrating Peptides
- (2008) Kristin L. Horton et al. CHEMISTRY & BIOLOGY
- Trimetazidine, a Metabolic Modulator, Has Cardiac and Extracardiac Benefits in Idiopathic Dilated Cardiomyopathy
- (2008) Helena Tuunanen et al. CIRCULATION
- Effect of Intra-Coronary Nicorandil Administration Prior to Reperfusion in Acute ST Segment Elevation Myocardial Infarction
- (2008) Han Cheol Lee et al. CIRCULATION JOURNAL
- Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice
- (2008) Olesya Vakhrusheva et al. CIRCULATION RESEARCH
- Vitamins E and C in the Prevention of Cardiovascular Disease in Men
- (2008) Howard D. Sesso JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Resveratrol Inhibits Cardiac Hypertrophy via AMP-activated Protein Kinase and Akt
- (2008) Anita Y. M. Chan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction
- (2008) Christophe Piot et al. NEW ENGLAND JOURNAL OF MEDICINE
- Autophagy is an adaptive response in desmin-related cardiomyopathy
- (2008) P. Tannous et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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