Extracellular nucleosides and nucleotides as immunomodulators

Targeting adenosine in cancer immunotherapy: a review of recent progress

(2017) Theresa L Whiteside   Expert Review of Anticancer Therapy

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states

(2017) David Furman et al.   NATURE MEDICINE

Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses

(2016) Arabella Young et al.   CANCER CELL

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

(2016) Federico Pietrocola et al.   CANCER CELL

Fasting improves anticancer immunosurveillance via autophagy induction in malignant cells

(2016) Federico Pietrocola et al.   CELL CYCLE

Extracellular ADP facilitates monocyte recruitment in bacterial infection via ERK signaling

(2016) Xiaoyu Zhang et al.   Cellular & Molecular Immunology

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

(2016) Christina Pfirschke et al.   IMMUNITY

Medicinal chemistry of adenosine, P2Y and P2X receptors

(2016) Kenneth A. Jacobson et al.   NEUROPHARMACOLOGY

Extracellular purines, purinergic receptors and tumor growth

(2016) F Di Virgilio et al.   ONCOGENE

The oncolytic peptide LTX-315 triggers immunogenic cell death

(2016) H Zhou et al.   Cell Death & Disease

Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy

(2016) Heng Yang et al.   OncoImmunology

Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives

(2015) Sébastien Roger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

CD73 Is Associated with Poor Prognosis in High-Grade Serous Ovarian Cancer

(2015) Martin Turcotte et al.   CANCER RESEARCH

Classifying Cancers Based on T-cell Infiltration and PD-L1

(2015) Michele W.L. Teng et al.   CANCER RESEARCH

Big opportunities for small molecules in immuno-oncology

(2015) Jerry L. Adams et al.   NATURE REVIEWS DRUG DISCOVERY

Live to die another way: modes of programmed cell death and the signals emanating from dying cells

(2015) Yaron Fuchs et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Perception of self: distinguishing autoimmunity from autoinflammation

(2015) Tessa S. van Kempen et al.   Nature Reviews Rheumatology

Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer

(2015) Julie Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1

(2015) E. Vacchelli et al.   SCIENCE

Adenosine Receptor 2A Blockade Increases the Efficacy of Anti–PD-1 through Enhanced Antitumor T-cell Responses

(2015) Paul A. Beavis et al.   Cancer Immunology Research

High hydrostatic pressure induces immunogenic cell death in human tumor cells

(2014) Jitka Fucikova et al.   INTERNATIONAL JOURNAL OF CANCER

Chemotherapeutic Drugs Induce ATP Release via Caspase-gated Pannexin-1 Channels and a Caspase/Pannexin-1-independent Mechanism

(2014) Andrea Boyd-Tressler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Expression of Ecto-Nucleotidases CD39 and CD73 in Human Endometrial Tumors

(2014) Elisabet Aliagas et al.   MEDIATORS OF INFLAMMATION

Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

(2014) Antonella Sistigu et al.   NATURE MEDICINE

Immune-dependent antineoplastic effects of cisplatin plus pyridoxine in non-small-cell lung cancer

(2014) F Aranda et al.   ONCOGENE

Glucose metabolism is inhibited by caspases upon the induction of apoptosis

(2014) L A Pradelli et al.   Cell Death & Disease

A dual role for autophagy in a murine model of lung cancer

(2014) Shuan Rao et al.   Nature Communications

Co-blockade of immune checkpoints and adenosine A2Areceptor suppresses metastasis

(2014) Arabella Young et al.   OncoImmunology

Screening of novel immunogenic cell death inducers within the NCI Mechanistic Diversity Set

(2014) Abdul Qader Sukkurwala et al.   OncoImmunology

Molecular mechanisms of ATP secretion during immunogenic cell death

(2013) I Martins et al.   CELL DEATH AND DIFFERENTIATION

Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs

(2013) B. Allard et al.   CLINICAL CANCER RESEARCH

Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

(2013) Yuting Ma et al.   IMMUNITY

Synergy between the ectoenzymes CD39 and CD73 contributes to adenosinergic immunosuppression in human malignant gliomas

(2013) Shuo Xu et al.   NEURO-ONCOLOGY

Overexpression of CD73 in Prostate Cancer is Associated with Lymph Node Metastasis

(2013) Qing Yang et al.   PATHOLOGY & ONCOLOGY RESEARCH

CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer

(2013) S. Loi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD39 and CD73 in immunity and inflammation

(2013) Luca Antonioli et al.   TRENDS IN MOLECULAR MEDICINE

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

ATP is released from autophagic vesicles to the extracellular space in a VAMP7-dependent manner

(2012) Claudio Marcelo Fader et al.   Autophagy

CD73-Deficient Mice Are Resistant to Carcinogenesis

(2012) J. Stagg et al.   CANCER RESEARCH

Mechanisms of ATP release and signalling in the blood vessel wall

(2012) A. W. Lohman et al.   CARDIOVASCULAR RESEARCH

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

Stat3 and Gfi-1 Transcription Factors Control Th17 Cell Immunosuppressive Activity via the Regulation of Ectonucleotidase Expression

(2012) Fanny Chalmin et al.   IMMUNITY

Production of Adenosine by Ectonucleotidases: A Key Factor in Tumor Immunoescape

(2012) François Ghiringhelli et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

5′-ectonucleotidase mediates multiple-drug resistance in glioblastoma multiforme cells

(2012) Claudia Quezada et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Vesicular and conductive mechanisms of nucleotide release

(2012) Eduardo R. Lazarowski   Purinergic Signalling

Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death

(2012) L. Menger et al.   Science Translational Medicine

New markers for minimal residual disease detection in acute lymphoblastic leukemia

(2011) E. Coustan-Smith et al.   BLOOD

Programmed Cell Death in Animal Development and Disease

(2011) Yaron Fuchs et al.   CELL

CD39 Expression on T Lymphocytes Correlates With Severity of Disease in Patients With Chronic Lymphocytic Leukemia

(2011) Dianne Pulte et al.   Clinical Lymphoma Myeloma & Leukemia

CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice

(2011) Long Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Contribution of IL-17–producing γδ T cells to the efficacy of anticancer chemotherapy

(2011) Yuting Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adenosine A2B Receptor Blockade Slows Growth of Bladder and Breast Tumors

(2011) C. Cekic et al.   JOURNAL OF IMMUNOLOGY

Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation

(2011) Y. Qu et al.   JOURNAL OF IMMUNOLOGY

Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer

(2011) Beat M. Künzli et al.   Purinergic Signalling

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Peptidoglycan derived fromStaphylococcus epidermidisinduces Connexin43 hemichannel activity with consequences on the innate immune response in endothelial cells

(2010) Jennifer Robertson et al.   BIOCHEMICAL JOURNAL

Adenosine receptors and cancer

(2010) Stefania Gessi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Tumor Cell Death and ATP Release Prime Dendritic Cells and Efficient Anticancer Immunity

(2010) L. Aymeric et al.   CANCER RESEARCH

Chemotherapy induces ATP release from tumor cells

(2010) Isabelle Martins et al.   CELL CYCLE

CD39/ENTPD1 Expression by CD4+Foxp3+ Regulatory T Cells Promotes Hepatic Metastatic Tumor Growth in Mice

(2010) Xiaofeng Sun et al.   GASTROENTEROLOGY

Extracellular ATP May Contribute to Tissue Repair by Rapidly Stimulating Purinergic Receptor X7-Dependent Vascular Endothelial Growth Factor Release from Primary Human Monocytes

(2010) L. M. Hill et al.   JOURNAL OF IMMUNOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

(2010) Faraaz B. Chekeni et al.   NATURE

Extracellular adenosine triphosphate and adenosine in cancer

(2010) J Stagg et al.   ONCOGENE

Purinergic Signaling: A Fundamental Mechanism in Neutrophil Activation

(2010) Y. Chen et al.   Science Signaling

Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells

(2009) M Uhl et al.   CELL DEATH AND DIFFERENTIATION

Purinergic receptors in airway epithelia

(2009) Eduardo R Lazarowski et al.   CURRENT OPINION IN PHARMACOLOGY

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Immunogenic death of colon cancer cells treated with oxaliplatin

(2009) A Tesniere et al.   ONCOGENE

T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response

(2009) Michail V. Sitkovsky   TRENDS IN IMMUNOLOGY