Mitophagy Is Required for Acute Cardioprotection by Simvastatin

Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms

(2012) Anil Kumar et al.   BRAIN RESEARCH

Mitochondria and Mitophagy

(2012) Dieter A. Kubli et al.   CIRCULATION RESEARCH

Autophagy: an affair of the heart

(2012) Roberta A. Gottlieb et al.   HEART FAILURE REVIEWS

Parkin Protein Deficiency Exacerbates Cardiac Injury and Reduces Survival following Myocardial Infarction

(2012) Dieter A. Kubli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of statins on liver cell function and inflammation in septic rats

(2012) Aline Maria Stolf et al.   JOURNAL OF SURGICAL RESEARCH

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

Autophagy Activation: A Novel Mechanism of Atorvastatin to Protect Mesenchymal Stem Cells from Hypoxia and Serum Deprivation via AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Pathway

(2012) Qian Zhang et al.   STEM CELLS AND DEVELOPMENT

PPARγ in coronary atherosclerosis: In vivo expression pattern and correlations with hyperlipidemic status and statin treatment

(2011) Angela Pucci et al.   ATHEROSCLEROSIS

Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt

(2011) Peter J. Mullen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hydrophobic statins induce autophagy and cell death in human rhabdomyosarcoma cells by depleting geranylgeranyl diphosphate

(2011) Makoto Araki et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes

(2011) Hyo-Bum Kwak et al.   FREE RADICAL BIOLOGY AND MEDICINE

In Vivo Cardioprotection by Pitavastatin From Ischemic-reperfusion Injury Through Suppression of IKK/NF-κB and Upregulation of pAkt–e-NOS

(2011) Salma Malik et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Amlodipine and atorvastatin exert protective and additive effects via antiapoptotic and antiautophagic mechanisms after transient middle cerebral artery occlusion in Zucker metabolic syndrome rats

(2011) Xuemei Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

CARDIOPROTECTIVE EFFECTS OF CHLORAMPHENICOL ARE MEDIATED BY AUTOPHAGY

(2011) Zoltan Giricz et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Preconditioning Involves Selective Mitophagy Mediated by Parkin and p62/SQSTM1

(2011) Chengqun Huang et al.   PLoS One

Mitochondrial KATP channels-derived reactive oxygen species activate pro-survival pathway in pravastatin-induced cardioprotection

(2010) Luong Cong Thuc et al.   APOPTOSIS

Mitochondrial Dysfunction Induced by Statin Contributes to Endothelial Dysfunction in Patients with Coronary Artery Disease

(2010) Yuk-Ling Dai et al.   Cardiovascular Toxicology

Simvastatin induces derepression of PTEN expression via NFκB to inhibit breast cancer cell growth

(2010) Nayana Ghosh-Choudhury et al.   CELLULAR SIGNALLING

Profound Cardioprotection With Chloramphenicol Succinate in the Swine Model of Myocardial Ischemia-Reperfusion Injury

(2010) J. A. Sala-Mercado et al.   CIRCULATION

Juvenile Exposure to Anthracyclines Impairs Cardiac Progenitor Cell Function and Vascularization Resulting in Greater Susceptibility to Stress-Induced Myocardial Injury in Adult Mice

(2010) Chengqun Huang et al.   CIRCULATION

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Rosuvastatin Lowers Coenzyme Q10 Levels, but not Mitochondrial Adenosine Triphosphate Synthesis, in Children with Familial Hypercholesterolemia

(2010) Hans J. Avis et al.   JOURNAL OF PEDIATRICS

Mechanism of Statin-Induced Contractile Dysfunction in Rat Cultured Skeletal Myofibers

(2010) Syoko Tanaka et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Coenzyme Q10, Rosuvastatin, and Clinical Outcomes in Heart Failure

(2010) John J.V. McMurray et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Statin-induced autophagy by inhibition of geranylgeranyl biosynthesis in prostate cancer PC3 cells

(2010) Ankur Parikh et al.   PROSTATE

Induction of RISK by HMG-CoA reductase inhibition affords cardioprotection after myocardial infarction

(2009) Gemma Vilahur et al.   ATHEROSCLEROSIS

Cardioprotection and altered mitochondrial adenine nucleotide transport

(2009) Charles Steenbergen et al.   BASIC RESEARCH IN CARDIOLOGY

Effect of simvastatin on cholesterol metabolism in C2C12 myotubes and HepG2 cells, and consequences for statin-induced myopathy

(2009) Peter James Mullen et al.   BIOCHEMICAL PHARMACOLOGY

Mobility and function of Coenzyme Q (ubiquinone) in the mitochondrial respiratory chain

(2009) Giorgio Lenaz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Changes in PPAR gene expression and myocardial tolerance to ischaemia: relevance to pleiotropic effects of statinsThis article is one of a selection of papers published in a special issue on Advances in Cardiovascular Research.

(2009) Táňa Ravingerová et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Number Needed to Treat With Rosuvastatin to Prevent First Cardiovascular Events and Death Among Men and Women With Low Low-Density Lipoprotein Cholesterol and Elevated High-Sensitivity C-Reactive Protein

(2009) Paul M Ridker et al.  

Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect

(2009) Peirang Cao et al.   FASEB JOURNAL

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Statins and cardioprotection — More than just lipid lowering?

(2009) Andrew Ludman et al.   PHARMACOLOGY & THERAPEUTICS

LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection

(2008) Hua Yuan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Interactions between cell death induced by statins and 7-ketocholesterol in rabbit aorta smooth muscle cells

(2008) W Martinet et al.   BRITISH JOURNAL OF PHARMACOLOGY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Plasma coenzyme Q10 predicts lipid-lowering response to high-dose atorvastatin

(2008) Michael A. Pacanowski et al.   Journal of Clinical Lipidology