Biosynthesis and chemical diversity of β-lactone natural products

Characterization of Tetrahydrolipstatin and Stereoderivatives on the Inhibition of Essential Mycobacterium tuberculosis Lipid Esterases

(2018) Christopher M. Goins et al.   BIOCHEMISTRY

Bisoxazolomycin A: a new natural product from ‘Streptomyces subflavus subsp. irumaensis’ AM-3603

(2017) Wilaiwan Koomsiri et al.   JOURNAL OF ANTIBIOTICS

Active Multienzyme Assemblies for Long-Chain Olefinic Hydrocarbon Biosynthesis

(2017) James K. Christenson et al.   JOURNAL OF BACTERIOLOGY

Quantitative Map of β-Lactone-Induced Virulence Regulation

(2017) Joanna Krysiak et al.   JOURNAL OF PROTEOME RESEARCH

A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst

(2017) Aaron A. Koch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Lactone formation during product release from a nonribosomal peptide synthetase

(2017) Jason E Schaffer et al.   Nature Chemical Biology

antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification

(2017) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

An L-threonine transaldolase is required for L-threo-β-hydroxy-α-amino acid assembly during obafluorin biosynthesis

(2017) Thomas A. Scott et al.   Nature Communications

Thiol Probes To Detect Electrophilic Natural Products Based on Their Mechanism of Action

(2016) Gabriel Castro-Falcón et al.   ACS Chemical Biology

Targeted Covalent Inhibitors for Drug Design

(2016) Thomas A. Baillie   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Convergent biosynthetic pathways to β-lactam antibiotics

(2016) Craig A Townsend   CURRENT OPINION IN CHEMICAL BIOLOGY

Ostalactones A–C, β- and ε-Lactones with Lipase Inhibitory Activity from the Cultured Basidiomycete Stereum ostrea

(2016) Hahk-Soo Kang et al.   JOURNAL OF NATURAL PRODUCTS

Progress and prospects for small-molecule probes of bacterial imaging

(2016) Ozden Kocaoglu et al.   Nature Chemical Biology

Translocation of the thioesterase domain for the redesign of plipastatin synthetase

(2016) Ling Gao et al.   Scientific Reports

Novel Natural Oximes and Oxime Esters with a Vibralactone Backbone from the Basidiomycete Boreostereum vibrans

(2016) He-Ping Chen et al.   ChemistryOpen

Profiling of β-Lactam Selectivity for Penicillin-Binding Proteins in Streptococcus pneumoniae D39

(2015) Ozden Kocaoglu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Profiling of β-Lactam Selectivity for Penicillin-Binding Proteins in Escherichia coli Strain DC2

(2015) Ozden Kocaoglu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cystargolides, 20S Proteasome Inhibitors Isolated from Kitasatospora cystarginea

(2015) Krista A. Gill et al.   JOURNAL OF NATURAL PRODUCTS

β-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis

(2015) Nicole M. Gaudelli et al.   NATURE

Gracilins: Spongionella-derived promising compounds for Alzheimer disease

(2015) Marta Leirós et al.   NEUROPHARMACOLOGY

Operon for Biosynthesis of Lipstatin, the Beta-Lactone Inhibitor of Human Pancreatic Lipase

(2014) Tingli Bai et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Total Syntheses of (±)-Omphadiol and (±)-Pyxidatol C through a Cis-Fused 5,7-Carbocyclic Common Intermediate

(2014) Lili Zhou et al.   JOURNAL OF ORGANIC CHEMISTRY

Omuralide and Vibralactone: Differences in the Proteasome- β-Lactone-γ-Lactam Binding Scaffold Alter Target Preferences

(2013) Anja List et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Elucidating the Biosynthetic Pathway for Vibralactone: A Pancreatic Lipase Inhibitor with a Fused Bicyclic β-Lactone

(2013) Pei-Ji Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biosynthesis of ebelactone A: isotopic tracer, advanced precursor and genetic studies reveal a thioesterase-independent cyclization to give a polyketide β-lactone

(2013) Morgan A Wyatt et al.   JOURNAL OF ANTIBIOTICS

Targeting Lipid Esterases in Mycobacteria Grown Under Different Physiological Conditions Using Activity-based Profiling with Tetrahydrolipstatin (THL)

(2013) Madhu Sudhan Ravindran et al.   MOLECULAR & CELLULAR PROTEOMICS

Design and synthesis of the stabilized analogs of belactosin A with the unnatural cis-cyclopropane structure

(2013) Shuhei Kawamura et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Biochemical and Structural Basis for Inhibition of Enterococcus faecalis Hydroxymethylglutaryl-CoA Synthase, mvaS, by Hymeglusin

(2012) D. Andrew Skaff et al.   BIOCHEMISTRY

Synthesis and biological activity of simplified belactosin C analogues

(2012) Armin de Meijere et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and biological investigation of the β-thiolactone and β-lactam analogs of tetrahydrolipstatin

(2012) Sylvain Aubry et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

β-Lactams and β-lactones as activity-based probes in chemical biology

(2012) Thomas Böttcher et al.   MedChemComm

Vibralactone as a Tool to Study the Activity and Structure of the ClpP1P2 Complex from Listeria monocytogenes

(2011) Evelyn Zeiler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mining the Cinnabaramide Biosynthetic Pathway to Generate Novel Proteasome Inhibitors

(2011) Shwan Rachid et al.   CHEMBIOCHEM

Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads

(2011) Nicholas P. West et al.   CHEMICAL COMMUNICATIONS

Cloning, purification, crystallization and preliminary X-ray diffraction of the OleC protein from Stenotrophomonas maltophilia involved in head-to-head hydrocarbon biosynthesis

(2010) Janice A. Frias et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Salinosporamide Natural Products: Potent 20 S Proteasome Inhibitors as Promising Cancer Chemotherapeutics

(2010) Tobias A. M. Gulder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Widespread Head-to-Head Hydrocarbon Biosynthesis in Bacteria and Role of OleA

(2010) D. J. Sukovich et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The Discovery of Salinosporamide K from the Marine Bacterium “Salinispora pacifica” by Genome Mining Gives Insight into Pathway Evolution

(2010) Alessandra S. Eustáquio et al.   CHEMBIOCHEM

Acylating drugs: redesigning natural covalent inhibitors

(2010) Arthur F Kluge et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Oxazolomycin Biosynthesis inStreptomyces albusJA3453 Featuring an “Acyltransferase-less” Type I Polyketide Synthase That Incorporates Two Distinct Extender Units

(2010) Chunhua Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineering Fluorometabolite Production: Fluorinase Expression inSalinispora tropicaYields Fluorosalinosporamide†

(2010) Alessandra S. Eustáquio et al.   JOURNAL OF NATURAL PRODUCTS

The antibiotics market

(2010) Bashar Hamad   NATURE REVIEWS DRUG DISCOVERY

Conformational Dynamics in the Acyl-CoA Synthetases, Adenylation Domains of Non-ribosomal Peptide Synthetases, and Firefly Luciferase

(2009) Andrew M. Gulick   ACS Chemical Biology

Bioactive Diterpene Derivatives from the Marine SpongeSpongionellasp.

(2009) Mostafa E. Rateb et al.   JOURNAL OF NATURAL PRODUCTS

Asymmetric Synthesis, Structure, and Reactivity of Unexpectedly Stable Spiroepoxy-β-Lactones Including Facile Conversion to Tetronic Acids: Application to (+)-Maculalactone A

(2009) Richard J. Duffy et al.   JOURNAL OF ORGANIC CHEMISTRY

Pyrrolizidine alkaloids sequestered by Solomon Island Danaine butterflies. The feeding preferences of the Danainae and Ithomiinae

(2009) J. A. Edgar   JOURNAL OF ZOOLOGY

Three-dimensional structure-activity relationship study of belactosin A and its stereo- and regioisomers: development of potent proteasome inhibitors by a stereochemical diversity-oriented strategy

(2009) Keisuke Yoshida et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

(2009) A. S. Eustaquio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-Lactones as Privileged Structures for the Active-Site Labeling of Versatile Bacterial Enzyme Classes

(2008) Thomas Böttcher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

β-Lactams as Selective Chemical Probes for the in Vivo Labeling of Bacterial Enzymes Involved in Cell Wall Biosynthesis, Antibiotic Resistance, and Virulence

(2008) Isabell Staub et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY