Design and synthesis of the stabilized analogs of belactosin A with the unnatural cis-cyclopropane structure

Potent Proteasome Inhibitors Derived from the Unnatural cis-Cyclopropane Isomer of Belactosin A: Synthesis, Biological Activity, and Mode of Action

(2013) Shuhei Kawamura et al.   JOURNAL OF MEDICINAL CHEMISTRY

Investigation of the Noncovalent Binding Mode of Covalent Proteasome Inhibitors around the Transition State by Combined Use of Cyclopropylic Strain-Based Conformational Restriction and Computational Modeling

(2013) Shuhei Kawamura et al.   JOURNAL OF MEDICINAL CHEMISTRY

Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

(2012) Alexei F. Kisselev et al.   CHEMISTRY & BIOLOGY

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

(2011) Antonia F. Stepan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Synthesis and biological activity of optimized belactosin C congeners

(2011) Vadim S. Korotkov et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Building on bortezomib: second-generation proteasome inhibitors as anti-cancer therapy

(2010) Lawrence R. Dick et al.   DRUG DISCOVERY TODAY

Investigation of the Bioactive Conformation of Histamine H3Receptor Antagonists by the Cyclopropylic Strain-Based Conformational Restriction Strategy

(2010) Mizuki Watanabe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Three-dimensional structure-activity relationship study of belactosin A and its stereo- and regioisomers: development of potent proteasome inhibitors by a stereochemical diversity-oriented strategy

(2009) Keisuke Yoshida et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Role of Biotransformation Studies in Minimizing Metabolism-Related Liabilities in Drug Discovery

(2008) Yue-Zhong Shu et al.   AAPS Journal

Synthesis of 1-arylpiperazyl-2-phenylcyclopropanes designed as antidopaminergic agents: Cyclopropane-based conformationally restricted analogs of haloperidol

(2008) Kazuya Yamaguchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Proteasome Inhibitors in Cancer Therapy: Lessons from the First Decade

(2008) R. Z. Orlowski et al.   CLINICAL CANCER RESEARCH

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synthesis of 2,3- and 3,4-Methanoamino Acid Equivalents with Stereochemical Diversity and Their Conversion into the Tripeptide Proteasome Inhibitor Belactosin A and Its Highly PotentCis-Cyclopropane Stereoisomer

(2008) Keisuke Yoshida et al.   ORGANIC LETTERS

The roles of the proteasome pathway in signal transduction and neurodegenerative diseases

(2008) Jiao-Jiao Chen et al.   Neuroscience Bulletin