β-Lactams and β-lactones as activity-based probes in chemical biology

Development of Highly Potent Inhibitors of the Ras-Targeting Human Acyl Protein Thioesterases Based on Substrate Similarity Design

(2011) Christian Hedberg et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M

(2011) Marion Rusch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Vibralactone as a Tool to Study the Activity and Structure of the ClpP1P2 Complex from Listeria monocytogenes

(2011) Evelyn Zeiler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development and characterization of improved β-lactone-based anti-virulence drugs targeting ClpP

(2011) Evelyn Zeiler et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Natural Products and Their Biological Targets: Proteomic and Metabolomic Labeling Strategies

(2010) Thomas Böttcher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

New cis-Configured Aziridine-2-carboxylates as Aspartic Acid Protease Inhibitors

(2010) Christian Büchold et al.   ChemMedChem

Acylating drugs: redesigning natural covalent inhibitors

(2010) Arthur F Kluge et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Binding of ceftaroline to penicillin-binding proteins of Staphylococcus aureus and Streptococcus pneumoniae

(2010) H. Moisan et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Small-molecule inhibition of APT1 affects Ras localization and signaling

(2010) Frank J Dekker et al.   Nature Chemical Biology

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mutation of the Active Site Carboxy-Lysine (K70) of OXA-1 β-Lactamase Results in a Deacylation-Deficient Enzyme

(2009) Kyle D. Schneider et al.   BIOCHEMISTRY

Structurally Refined β-Lactones as Potent Inhibitors of Devastating Bacterial Virulence Factors

(2009) Thomas Böttcher et al.   CHEMBIOCHEM

β-Lactones Decrease the Intracellular Virulence ofListeria monocytogenesin Macrophages

(2009) Thomas Böttcher et al.   ChemMedChem

β-Lactam Probes As Selective Chemical-Proteomic Tools for the Identification and Functional Characterization of Resistance Associated Enzymes in MRSA

(2009) Isabell Staub et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activity-Based Proteome Profiling of Potential Cellular Targets of Orlistat − An FDA-Approved Drug with Anti-Tumor Activities

(2009) Peng-Yu Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of Fatty Acid Synthase by Orlistat Accelerates Gastric Tumor Cell Apoptosis in Culture and Increases Survival Rates in Gastric Tumor Bearing Mice In Vivo

(2009) Shawn Dowling et al.   LIPIDS

Next-generation DNA sequencing techniques

(2009) Wilhelm J. Ansorge   New Biotechnology

Chemoselective Ligation and Modification Strategies for Peptides and Proteins

(2008) Christian P. R. Hackenberger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

β-Lactones as Privileged Structures for the Active-Site Labeling of Versatile Bacterial Enzyme Classes

(2008) Thomas Böttcher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry

(2008) Benjamin F. Cravatt et al.   Annual Review of Biochemistry

Activity-based probes as a tool for functional proteomic analysis of proteases

(2008) Marko Fonović et al.   Expert Review of Proteomics

Structural Analysis of Spiro β-Lactone Proteasome Inhibitors

(2008) Michael Groll et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Lactams as Selective Chemical Probes for the in Vivo Labeling of Bacterial Enzymes Involved in Cell Wall Biosynthesis, Antibiotic Resistance, and Virulence

(2008) Isabell Staub et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Lactones as Specific Inhibitors of ClpP Attenuate the Production of Extracellular Virulence Factors ofStaphylococcus aureus

(2008) Thomas Böttcher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana

(2008) Zheming Wang et al.   Nature Chemical Biology