Mining the Cinnabaramide Biosynthetic Pathway to Generate Novel Proteasome Inhibitors

Salinosporamide Natural Products: Potent 20 S Proteasome Inhibitors as Promising Cancer Chemotherapeutics

(2010) Tobias A. M. Gulder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Prephenate Decarboxylases: A New Prephenate-Utilizing Enzyme Family That Performs Nonaromatizing Decarboxylation en Route to Diverse Secondary Metabolites

(2010) Sarah Mahlstedt et al.   BIOCHEMISTRY

Biosynthesis of Thuggacins in Myxobacteria: Comparative Cluster Analysis Reveals Basis for Natural Product Structural Diversity

(2010) Kathrin Buntin et al.   CHEMISTRY & BIOLOGY

Function-Oriented Biosynthesis of β-Lactone Proteasome Inhibitors inSalinispora tropica

(2009) Markus Nett et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biosynthesis of Salinosporamides from α,β-Unsaturated Fatty Acids: Implications for Extending Polyketide Synthase Diversity

(2009) Yuan Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

(2009) A. S. Eustaquio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploration and engineering of biosynthetic pathways in the marine actinomycete Salinispora tropica

(2009) Markus Nett et al.   PURE AND APPLIED CHEMISTRY

Mutasynthesis of Fluorosalinosporamide, a Potent and Reversible Inhibitor of the Proteasome

(2008) Alessandra S. Eustáquio et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery and development of the anticancer agent salinosporamide A (NPI-0052)

(2008) William Fenical et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Protein–Protein Interactions in Multienzyme Megasynthetases

(2008) Kira J. Weissman et al.   CHEMBIOCHEM

Advances in and applications of proteasome inhibitors

(2008) Bradley S Moore et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides

(2008) Rama Rao Manam et al.   JOURNAL OF MEDICINAL CHEMISTRY

Engineered Biosynthesis of Antiprotealide and Other Unnatural Salinosporamide Proteasome Inhibitors

(2008) Ryan P. McGlinchey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

How to tailor non-ribosomal peptide products—new clues about the structures and mechanisms of modifying enzymes

(2008) Stefan A. Samel et al.   Molecular BioSystems