β-Lactone formation during product release from a nonribosomal peptide synthetase

Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-like Proteins Support a Highly Dynamic Domain Architecture

(2016) Bradley R. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate?

(2016) Mark E. Horsman et al.   NATURAL PRODUCT REPORTS

Structures of two distinct conformations of holo-non-ribosomal peptide synthetases

(2016) Eric J. Drake et al.   NATURE

Synthetic cycle of the initiation module of a formylating nonribosomal peptide synthetase

(2016) Janice M. Reimer et al.   NATURE

Polyketide and nonribosomal peptide retro-biosynthesis and global gene cluster matching

(2016) Chris A Dejong et al.   Nature Chemical Biology

An Unusual Peroxo Intermediate of the Arylamine Oxygenase of the Chloramphenicol Biosynthetic Pathway

(2015) Thomas M. Makris et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis

(2015) Nicole M. Gaudelli et al.   NATURE

The Structure of a Transient Complex of a Nonribosomal Peptide Synthetase and a Cytochrome P450 Monooxygenase

(2014) Kristina Haslinger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

New Insights into Chloramphenicol Biosynthesis in Streptomyces venezuelae ATCC 10712

(2014) Lorena T. Fernández-Martínez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Operon for Biosynthesis of Lipstatin, the Beta-Lactone Inhibitor of Human Pancreatic Lipase

(2014) Tingli Bai et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Characterization of the N-oxygenase AurF from Streptomyces thioletus

(2014) Emmanuel Chanco et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Biosynthesis of the 4-Methyloxazoline-Containing Nonribosomal Peptides, JBIR-34 and -35, in Streptomyces sp. Sp080513GE-23

(2014) Adeline Muliandi et al.   CHEMISTRY & BIOLOGY

Epimerization and substrate gating by a TE domain in β-lactam antibiotic biosynthesis

(2014) Nicole M Gaudelli et al.   Nature Chemical Biology

Biosynthesis of ebelactone A: isotopic tracer, advanced precursor and genetic studies reveal a thioesterase-independent cyclization to give a polyketide β-lactone

(2013) Morgan A Wyatt et al.   JOURNAL OF ANTIBIOTICS

EcdGHK Are Three Tailoring Iron Oxygenases for Amino Acid Building Blocks of the Echinocandin Scaffold

(2013) Wei Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of the Amicetin Biosynthesis Gene Cluster from Streptomyces vinaceusdrappus NRRL 2363 Implicates Two Alternative Strategies for Amide Bond Formation

(2012) Gaiyun Zhang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Polyketide Proofreading by an Acyltransferase-like Enzyme

(2012) Katja Jensen et al.   CHEMISTRY & BIOLOGY

Amalgamation of Nucleosides and Amino Acids in Antibiotic Biosynthesis: Discovery of an l-Threonine:Uridine-5′-Aldehyde Transaldolase

(2012) Sandra Barnard-Britson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The enzymes of β-lactam biosynthesis

(2012) Refaat B. Hamed et al.   NATURAL PRODUCT REPORTS

Chemoselectivity in Chemical Biology: Acyl Transfer Reactions with Sulfur and Selenium

(2011) Nicholas A. McGrath et al.   ACCOUNTS OF CHEMICAL RESEARCH

Different Active-Site Loop Orientation in Serine Hydrolases versus Acyltransferases

(2011) Yun Jiang et al.   CHEMBIOCHEM

β-Lactone natural products and derivatives inactivate homoserine transacetylase, a target for antimicrobial agents

(2011) Gianfranco De Pascale et al.   JOURNAL OF ANTIBIOTICS

Crotonase Catalysis Enables Flexible Production of Functionalized Prolines and Carbapenams

(2011) Refaat B. Hamed et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NRPSpredictor2—a web server for predicting NRPS adenylation domain specificity

(2011) Marc Röttig et al.   NUCLEIC ACIDS RESEARCH

Salinosporamide Natural Products: Potent 20 S Proteasome Inhibitors as Promising Cancer Chemotherapeutics

(2010) Tobias A. M. Gulder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxazolomycin Biosynthesis inStreptomyces albusJA3453 Featuring an “Acyltransferase-less” Type I Polyketide Synthase That Incorporates Two Distinct Extender Units

(2010) Chunhua Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening

(2010) D. A. Bachovchin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

(2010) J. H. Taube et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ATP-Dependent Amide Ligases DdaG and DdaF Assemble the Fumaramoyl-Dipeptide Scaffold of the Dapdiamide Antibiotics

(2009) Marie A. Hollenhorst et al.   BIOCHEMISTRY

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

(2009) A. S. Eustaquio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis

(2008) Y. S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA