Synthesis and biological investigation of the β-thiolactone and β-lactam analogs of tetrahydrolipstatin

Development of Highly Potent Inhibitors of the Ras-Targeting Human Acyl Protein Thioesterases Based on Substrate Similarity Design

(2011) Christian Hedberg et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M

(2011) Marion Rusch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exploring the potential of the β-thiolactones in bioorganic chemistry

(2011) Sylvain Aubry et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Click-based synthesis and proteomic profiling of lipstatin analogues

(2010) Mun H. Ngai et al.   CHEMICAL COMMUNICATIONS

Acylating drugs: redesigning natural covalent inhibitors

(2010) Arthur F Kluge et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Synthesis and Structure−Activity Relationships ofN-(2-Oxo-3-oxetanyl)amides asN-Acylethanolamine-hydrolyzing Acid Amidase Inhibitors

(2010) Carlos Solorzano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bioinspired Total Synthesis and Human Proteasome Inhibitory Activity of (−)-Salinosporamide A, (−)-Homosalinosporamide A, and Derivatives Obtained via Organonucleophile Promoted Bis-cyclizations

(2010) Henry Nguyen et al.   JOURNAL OF ORGANIC CHEMISTRY

Double Diastereoselective, Nucleophile-Catalyzed Aldol Lactonizations (NCAL) Leading to β-Lactone Fused Carbocycles and Extensions to β-Lactone Fused Tetrahydrofurans

(2010) Kay A. Morris et al.   ORGANIC LETTERS

An Expedient Procedure for the Oxidative Cleavage of Olefinic Bonds with PhI(OAc)2, NMO, and Catalytic OsO4

(2010) K. C. Nicolaou et al.   ORGANIC LETTERS

SN2-Type Nucleophilic Opening of β-Thiolactones (Thietan-2-ones) as a Source of Thioacids for Coupling Reactions

(2009) David Crich et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic StaudingerVilarrasa Reaction for the Direct Ligation of Carboxylic Acids and Azides

(2009) Jordi Burés et al.   JOURNAL OF ORGANIC CHEMISTRY

Matrix Photochemistry, Photoelectron Spectroscopy, Solid-Phase Structure, and Ring Strain Energy of β-Propiothiolactone

(2009) Nahir Y. Dugarte et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Activity-Based Proteome Profiling of Potential Cellular Targets of Orlistat − An FDA-Approved Drug with Anti-Tumor Activities

(2009) Peng-Yu Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergency of Triazolium and Imidazolium-Derived NHCs for Catalytic, Enantioselective Cyclopentane Synthesis

(2009) Juthanat Kaeobamrung et al.   ORGANIC LETTERS

Growth Inhibition of Human Colon Cancer Cell Line HCT116 by Bis[2-(acylamino)phenyl] Disulfide and Its Action Mechanism

(2008) Satoshi Yamakawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

β-Lactam congeners of orlistat as inhibitors of fatty acid synthase

(2008) Wei Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of Novel β-Lactone Inhibitors of Fatty Acid Synthase

(2008) Robyn D. Richardson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enantioselective Total Syntheses of Omuralide, 7-epi-Omuralide, and (+)-Lactacystin

(2008) Christopher J. Hayes et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of (±)- and (−)-Vibralactone and Vibralactone C†

(2008) Quan Zhou et al.   JOURNAL OF ORGANIC CHEMISTRY

Rapid Synthesis of 1,3,4,4-Tetrasubstituted β-Lactams from Methyleneaziridines Using a Four-Component Reaction‡

(2008) Claire C. A. Cariou et al.   JOURNAL OF ORGANIC CHEMISTRY