Transient receptor potential vanilloid 1 as a therapeutic target in analgesia

Intact Microtubules Preserve Transient Receptor Potential Vanilloid 1 (TRPV1) Functionality through Receptor Binding

(2012) Barbara Storti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Surgical and Chemical Sensory Denervation on Non-neural Expression of the Transient Receptor Potential Vanilloid 1 (TRPV1) Receptors in the Rat

(2012) József Kun et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

High spontaneous activity of C-nociceptors in painful polyneuropathy

(2012) Inge Petter Kleggetveit et al.   PAIN

Sensory and Signaling Mechanisms of Bradykinin, Eicosanoids, Platelet-Activating Factor, and Nitric Oxide in Peripheral Nociceptors

(2012) Gábor Pethő et al.   PHYSIOLOGICAL REVIEWS

Receptor-targeting mechanisms of pain-causing toxins: How ow?

(2012) Christopher J. Bohlen et al.   TOXICON

Multisteric TRPV1 nocisensor: a target for analgesics

(2012) János Szolcsányi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The dilated TRPA1 channel pore state is blocked by amiloride and analogues

(2011) Tue G. Banke   BRAIN RESEARCH

Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch

(2011) P. Anand et al.   BRITISH JOURNAL OF ANAESTHESIA

NGX-4010, a Capsaicin 8% Dermal Patch, Administered Alone or in Combination With Systemic Neuropathic Pain Medications, Reduces Pain in Patients With Postherpetic Neuralgia

(2011) Gordon A. Irving et al.   CLINICAL JOURNAL OF PAIN

Inhibition of the Function of TRPV1-Expressing Nociceptive Sensory Neurons by Somatostatin 4 Receptor Agonism: echanism and Therapeutical Implications

(2011) Janos Szolcsanyi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The Vanilloid Agonist Resiniferatoxin for Interventional-Based Pain Control

(2011) Michael J. Iadarola et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Therapeutic Targeting of TRPV1 by Resiniferatoxin, from Preclinical Studies to Clinical Trials

(2011) Igor Kissin et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Identification of a Tetrameric Assembly Domain in the C Terminus of Heat-activated TRPV1 Channels

(2011) Feng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trpv1 Reporter Mice Reveal Highly Restricted Brain Distribution and Functional Expression in Arteriolar Smooth Muscle Cells

(2011) D. J. Cavanaugh et al.   JOURNAL OF NEUROSCIENCE

TRPV1 and TRPA1 Function and Modulation Are Target Tissue Dependent

(2011) S. Malin et al.   JOURNAL OF NEUROSCIENCE

Preservation of Acute Pain and Efferent Functions Following Intrathecal Resiniferatoxin-Induced Analgesia in Rats

(2011) Mahendra Bishnoi et al.   JOURNAL OF PAIN

Civamide Cream 0.075% in Patients with Osteoarthritis of the Knee: A 12-Week Randomized Controlled Clinical Trial with a Longterm Extension

(2011) T. J. SCHNITZER et al.   JOURNAL OF RHEUMATOLOGY

Transient receptor potential channels as therapeutic targets

(2011) Magdalene M. Moran et al.   NATURE REVIEWS DRUG DISCOVERY

The history of TRP channels, a commentary and reflection

(2011) Craig Montell   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The transient receptor potential family of ion channels

(2011) Bernd Nilius et al.   GENOME BIOLOGY

Nociception, neurogenic inflammation and thermoregulation in TRPV1 knockdown transgenic mice

(2010) Dániel Márton Tóth et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of Nociceptive Transmission at the Periphery Via TRPA1-TRPV1 Interactions

(2010) Armen N. Akopian   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

A “Cute” Desensitization of TRPV1

(2010) Filip Touska et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

TRPV1-lineage neurons are required for thermal sensation

(2010) Santosh K Mishra et al.   EMBO JOURNAL

Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bath

(2010) Valéria Tékus et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Transient receptor potential vanilloid-1 antagonists: a survey of recent patent literature

(2010) Eric A Voight et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

A Randomized, Controlled, Open-Label Study of the Long-Term Effects of NGX-4010, a High-Concentration Capsaicin Patch, on Epidermal Nerve Fiber Density and Sensory Function in Healthy Volunteers

(2010) William R. Kennedy et al.   JOURNAL OF PAIN

Modulation of single-channel properties of TRPV1 by phosphorylation

(2010) Milena Studer et al.   JOURNAL OF PHYSIOLOGY-LONDON

Acute and preventive pharmacologic treatment of cluster headache

(2010) G. J. Francis et al.   NEUROLOGY

A Multicenter, Randomized, Double-Blind, Controlled Study of NGX-4010, a High-Concentration Capsaicin Patch, for the Treatment of Postherpetic Neuralgia

(2010) Gordon A. Irving et al.   PAIN MEDICINE

Antinociceptive desensitizing actions of TRPV1 receptor agonists capsaicin, resiniferatoxin and N-oleoyldopamine as measured by determination of the noxious heat and cold thresholds in the rat

(2009) Kata Bölcskei et al.   EUROPEAN JOURNAL OF PAIN

A-kinase anchoring protein 150 controls protein kinase C-mediated phosphorylation and sensitization of TRPV1

(2009) Nathaniel A. Jeske et al.   PAIN

Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage

(2009) Parul Sikand et al.   PAIN

Betulin Is a Potent Anti-Tumor Agent that Is Enhanced by Cholesterol

(2009) Franziska B. Mullauer et al.   PLoS One

The pharmacological challenge to tame the transient receptor potential vanilloid-1 (TRPV1) nocisensor

(2008) P Holzer   BRITISH JOURNAL OF PHARMACOLOGY

Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway

(2008) Martin J. Gunthorpe et al.   DRUG DISCOVERY TODAY

Tunable Calcium Current through TRPV1 Receptor Channels

(2008) Damien S. K. Samways et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Separate Peripheral Pathways for Pruritus in Man

(2008) Barbara Namer et al.   JOURNAL OF NEUROPHYSIOLOGY

Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice

(2008) Thomas Christoph et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A functional equivalent of endoplasmic reticulum and Golgi in axons for secretion of locally synthesized proteins

(2008) Tanuja T. Merianda et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Tissue-Specific Regulation of Microvascular Diameter: Opposite Functional Roles of Neuronal and Smooth Muscle Located Vanilloid Receptor-1

(2008) T. Kark et al.   MOLECULAR PHARMACOLOGY

TRPV1 shows dynamic ionic selectivity during agonist stimulation

(2008) Man-Kyo Chung et al.   NATURE NEUROSCIENCE

Proinflammatory Mediators Modulate the Heat-Activated Ion Channel TRPV1 via the Scaffolding Protein AKAP79/150

(2008) Xuming Zhang et al.   NEURON

Thermal nociception and TRPV1 function are attenuated in mice lacking the nucleotide receptor P2Y2

(2008) Sacha A. Malin et al.   PAIN

Human Keratinocytes Are Vanilloid Resistant

(2008) László Pecze et al.   PLoS One

Structure of TRPV1 channel revealed by electron cryomicroscopy

(2008) V. Y. Moiseenkova-Bell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of ATP and its receptors on nociception in rat model of masseter muscle pain

(2007) Masamichi Shinoda et al.   PAIN