Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase Cδ

Phase II study of bryostatin 1 and vincristine for aggressive non-Hodgkin lymphoma relapsing after an autologous stem cell transplant

(2009) Paul M. Barr et al.   AMERICAN JOURNAL OF HEMATOLOGY

A Simple Analogue of Tumor-Promoting Aplysiatoxin Is an Antineoplastic Agent Rather Than a Tumor Promoter: Development of a Synthetically Accessible Protein Kinase C Activator with Bryostatin-like Activity

(2009) Yu Nakagawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Bryostatin 1 A-Ring Acetate is Not the Critical Determinant for Antagonism of Phorbol Ester-Induced Biological Responses

(2009) Gary E. Keck et al.   ORGANIC LETTERS

Phase II trial of sequential paclitaxel and 1 h infusion of bryostatin-1 in patients with advanced esophageal cancer

(2008) Geoffrey Y. Ku et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Wealth of Opportunity - The C1 Domain as a Target for Drug Development

(2008) P. Blumberg et al.   CURRENT DRUG TARGETS

Targeting Protein Kinase C (PKC) in Physiology and Cancer of the Gastric Cell System

(2008) Michael Fahrmann   CURRENT MEDICINAL CHEMISTRY

Characterization of the Interaction of Phorbol Esters with the C1 Domain of MRCK (Myotonic Dystrophy Kinase-related Cdc42 Binding Kinase) α/β

(2008) Sung Hee Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficient Synthetic Access to a New Family of Highly Potent Bryostatin Analogues via a Prins-Driven Macrocyclization Strategy

(2008) Paul A. Wender et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Convergent Assembly of Highly Potent Analogues of Bryostatin 1 via Pyran Annulation: Bryostatin Look-Alikes That Mimic Phorbol Ester Function

(2008) Gary E. Keck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches

(2008) Barry M. Trost et al.   NATURE

Substitution on the A-Ring Confers to Bryopyran Analogues the Unique Biological Activity Characteristic of Bryostatins and Distinct From That of the Phorbol Esters

(2008) Gary E. Keck et al.   ORGANIC LETTERS

Practical Synthesis of Prostratin, DPP, and Their Analogs, Adjuvant Leads Against Latent HIV

(2008) P. A. Wender et al.   SCIENCE

Function-Oriented Synthesis, Step Economy, and Drug Design

(2007) Paul A. Wender et al.   ACCOUNTS OF CHEMICAL RESEARCH