The Cyclophilin Inhibitor SCY-635 Disrupts Hepatitis C Virus NS5A-Cyclophilin A Complexes

The cyclophilin inhibitor SCY-635 suppresses viral replication and induces endogenous interferons in patients with chronic HCV genotype 1 infection

(2012) Sam Hopkins et al.   JOURNAL OF HEPATOLOGY

Preclinical Characterization of Naturally Occurring Polyketide Cyclophilin Inhibitors from the Sanglifehrin Family

(2011) Matthew A. Gregory et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Safety, pharmacokinetics, and antiviral activity of the cyclophilin inhibitor NIM811 alone or in combination with pegylated interferon in HCV-infected patients receiving 14 days of therapy

(2011) Eric Lawitz et al.   ANTIVIRAL RESEARCH

Telaprevir Alone or With Peginterferon and Ribavirin Reduces HCV RNA in Patients With Chronic Genotype 2 but Not Genotype 3 Infections

(2011) Graham R. Foster et al.   GASTROENTEROLOGY

Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus

(2011) Jean-Michel Pawlotsky   HEPATOLOGY

Domain 3 of NS5A Protein from the Hepatitis C Virus Has Intrinsic α-Helical Propensity and Is a Substrate of Cyclophilin A

(2011) Dries Verdegem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclophilin A Interacts with Domain II of Hepatitis C Virus NS5A and Stimulates RNA Binding in an Isomerase-Dependent Manner

(2011) T. L. Foster et al.   JOURNAL OF VIROLOGY

Mechanism of Resistance of Hepatitis C Virus Replicons to Structurally Distinct Cyclophilin Inhibitors

(2010) X. Puyang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A–cyclophilin A interaction to cyclophilin inhibitors

(2010) Udayan Chatterji et al.   JOURNAL OF HEPATOLOGY

The use of AlphaLISA technology to detect interaction between hepatitis C virus-encoded NS5A and cyclophilin A

(2010) Helen Waller et al.   JOURNAL OF VIROLOGICAL METHODS

Cyclosporine Inhibits a Direct Interaction between Cyclophilins and Hepatitis C NS5A

(2010) Fiona Fernandes et al.   PLoS One

DEB025 (Alisporivir) Inhibits Hepatitis C Virus Replication by Preventing a Cyclophilin A Induced Cis-Trans Isomerisation in Domain II of NS5A

(2010) Lotte Coelmont et al.   PLoS One

A Major Determinant of Cyclophilin Dependence and Cyclosporine Susceptibility of Hepatitis C Virus Identified by a Genetic Approach

(2010) Feng Yang et al.   PLoS Pathogens

Review: New direct-acting antivirals in the development for hepatitis C virus infection

(2010) Paul J. Pockros   Therapeutic Advances in Gastroenterology

Development of novel antiviral therapies for hepatitis C virus

(2010) Kai Lin   VIROLOGICA SINICA

SCY-635, a Novel Nonimmunosuppressive Analog of Cyclosporine That Exhibits Potent Inhibition of Hepatitis C Virus RNA Replication In Vitro

(2009) S. Hopkins et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of cellular and viral factors related to anti-hepatitis C virus activity of cyclophilin inhibitor

(2009) Kaku Goto et al.   CANCER SCIENCE

Hepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolylcis/transIsomerase Activity of Cyclophilins A and B

(2009) Xavier Hanoulle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Isomerase Active Site of Cyclophilin A Is Critical for Hepatitis C Virus Replication

(2009) Udayan Chatterji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role of Cyclophilin A and Its Prolyl-Peptidyl Isomerase Activity in the Structure and Function of the Hepatitis C Virus Replication Complex

(2009) Z. Liu et al.   JOURNAL OF VIROLOGY

Protease and polymerase inhibitors for the treatment of hepatitis C

(2009) Tarik Asselah et al.   LIVER INTERNATIONAL

Multiple cyclophilins involved in different cellular pathways mediate HCV replication

(2009) L. Alex Gaither et al.   VIROLOGY

Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics

(2009) Artur Kaul et al.   PLoS Pathogens

Emerging drugs for hepatitis C

(2008) Vincent Soriano et al.   EXPERT OPINION ON EMERGING DRUGS

The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus

(2008) Robert Flisiak et al.   HEPATOLOGY

Cyclophilin A Is an Essential Cofactor for Hepatitis C Virus Infection and the Principal Mediator of Cyclosporine Resistance In Vitro

(2008) F. Yang et al.   JOURNAL OF VIROLOGY