Marine-Sourced Anti-Cancer and Cancer Pain Control Agents in Clinical and Late Preclinical Development

Conopeptides as novel options for pain management

(2014) N.L. Daly et al.   DRUGS OF THE FUTURE

New Interfacial Microtubule Inhibitors of Marine Origin, PM050489/PM060184, with Potent Antitumor Activity and a Distinct Mechanism

(2013) Benet Pera et al.   ACS Chemical Biology

Marine Natural Products and Related Compounds as Anticancer Agents: an Overview of their Clinical Status

(2013) Karina Petit et al.   Anti-Cancer Agents in Medicinal Chemistry

Sense and nonsense of high-dose cytarabine for acute myeloid leukemia

(2013) B. Lowenberg   BLOOD

Inhibitory effects of marine-derived DNA-binding anti-tumour tetrahydroisoquinolines on the Fanconi anaemia pathway

(2013) Sandra Martínez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Spinal actions of ω-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model

(2013) A Jayamanne et al.   BRITISH JOURNAL OF PHARMACOLOGY

A phase I pharmacokinetic study of PM00104 (Zalypsis®) administered as a 24-h intravenous infusion every 3 weeks in patients with advanced solid tumors

(2013) J. Capdevila et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Medicinal Chemistry and Chemical Biology of Diketopiperazine-Type Antimicrotubule and Vascular-Disrupting Agents

(2013) Yoshio Hayashi et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Synthesis of Tetrodotoxin, a Classic but Still Fascinating Natural Product

(2013) Toshio Nishikawa et al.   CHEMICAL RECORD

Comparison ofin vitroandin vivobiological effects of trabectedin, lurbinectedin (PM01183) and Zalypsis® (PM00104)

(2013) Michela Romano et al.   INTERNATIONAL JOURNAL OF CANCER

Takeda's Oncology Discovery Strategy

(2013) Brian DeSchuytner et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Microbial natural products: molecular blueprints for antitumor drugs

(2013) Lesley-Ann Giddings et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Isolation and First Total Synthesis of PM050489 and PM060184, Two New Marine Anticancer Compounds

(2013) María Jesús Martín et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phase II study of weekly PM00104 (ZALYPSIS®) in patients with pretreated advanced/metastatic endometrial or cervical cancer

(2013) Lainie P. Martin et al.   MEDICAL ONCOLOGY

DCDT2980S, an Anti-CD22-Monomethyl Auristatin E Antibody-Drug Conjugate, Is a Potential Treatment for Non-Hodgkin Lymphoma

(2013) D. Li et al.   MOLECULAR CANCER THERAPEUTICS

From micrograms to grams: scale-up synthesis of eribulin mesylate

(2013) Melvin J. Yu et al.   NATURAL PRODUCT REPORTS

Brentuximab Vedotin: A CD30-Directed Antibody-Cytotoxic Drug Conjugate

(2013) Ashley M. Newland et al.   PHARMACOTHERAPY

Commercial Manufacture of Halaven®: Chemoselective Transformations En Route to Structurally Complex Macrocyclic Ketones

(2013) Francis Fang et al.   SYNLETT

First-in-man phase I trial of two schedules of the novel synthetic tetrahydroisoquinoline alkaloid PM00104 (Zalypsis) in patients with advanced solid tumours

(2012) T A Yap et al.   BRITISH JOURNAL OF CANCER

Phase I study of PM00104 (Zalypsis®) administered as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors

(2012) Christophe Massard et al.   INVESTIGATIONAL NEW DRUGS

Astellas' Drug Discovery Strategy: Focus on Oncology

(2012) Y. Yanagita et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Intracutaneous and Intravesical Immunotherapy With Keyhole Limpet Hemocyanin Compared With Intravesical Mitomycin in Patients With Non–Muscle-Invasive Bladder Cancer: Results From a Prospective Randomized Phase III Trial

(2012) Rianne J.M. Lammers et al.   JOURNAL OF CLINICAL ONCOLOGY

The application of genomic and molecular data in the treatment of chronic cancer pain

(2012) Ali Turabi et al.   JOURNAL OF SURGICAL ONCOLOGY

Bacterial Biosynthesis and Maturation of the Didemnin Anti-cancer Agents

(2012) Ying Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tetrodotoxin (TTX) as a Therapeutic Agent for Pain

(2012) Francisco Rafael Nieto et al.   Marine Drugs

Long-term Tumor Regression Induced by an Antibody-Drug Conjugate That Targets 5T4, an Oncofetal Antigen Expressed on Tumor-Initiating Cells

(2012) P. Sapra et al.   MOLECULAR CANCER THERAPEUTICS

Didemnins, tamandarins and related natural products

(2012) Jisun Lee et al.   NATURAL PRODUCT REPORTS

Pharmacokinetic Considerations for Antibody Drug Conjugates

(2012) Kedan Lin et al.   PHARMACEUTICAL RESEARCH

The molecular mystique of tetrodotoxin

(2012) Edward G. Moczydlowski   TOXICON

On the origins and biosynthesis of tetrodotoxin

(2011) Rocky Chau et al.   AQUATIC TOXICOLOGY

Impact of Drug Conjugation on Pharmacokinetics and Tissue Distribution of Anti-STEAP1 Antibody–Drug Conjugates in Rats

(2011) C. Andrew Boswell et al.   BIOCONJUGATE CHEMISTRY

In vitro and in vivo evaluation of select kahalalide F analogs with antitumor and antifungal activities

(2011) Abbas Gholipour Shilabin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Selective Overproduction of the Proteasome Inhibitor Salinosporamide A via Precursor Pathway Regulation

(2011) Anna Lechner et al.   CHEMISTRY & BIOLOGY

A phase I and pharmacokinetic study of plitidepsin in children with advanced solid tumours: An Innovative Therapies for Children with Cancer (ITCC) study

(2011) Birgit Geoerger et al.   EUROPEAN JOURNAL OF CANCER

In Vitro and In Vivo Responses of Advanced Prostate Tumors to PSMA ADC, an Auristatin-Conjugated Antibody to Prostate-Specific Membrane Antigen

(2011) X. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Trabectedin and Its C Subunit Modified Analogue PM01183 Attenuate Nucleotide Excision Repair and Show Activity toward Platinum-Resistant Cells

(2011) D. G. Soares et al.   MOLECULAR CANCER THERAPEUTICS

Phase III Multicenter Clinical Trial of the Sialyl-TN (STn)-Keyhole Limpet Hemocyanin (KLH) Vaccine for Metastatic Breast Cancer

(2011) D. Miles et al.   ONCOLOGIST

Antibody drug conjugates — Trojan horses in the war on cancer

(2011) U. Iyer et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity

(2010) JFM Leal et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting apoptosis pathways by natural compounds in cancer: Marine compounds as lead structures and chemical tools for cancer therapy

(2010) Karin von Schwarzenberg et al.   CANCER LETTERS

The Discovery of Salinosporamide K from the Marine Bacterium “Salinispora pacifica” by Genome Mining Gives Insight into Pathway Evolution

(2010) Alessandra S. Eustáquio et al.   CHEMBIOCHEM

Glycoprotein Nonmetastatic B Is an Independent Prognostic Indicator of Recurrence and a Novel Therapeutic Target in Breast Cancer

(2010) A. A. N. Rose et al.   CLINICAL CANCER RESEARCH

Brentuximab vedotin

(2010) A. Copeland et al.   DRUGS OF THE FUTURE

Brentuximab vedotin: delivering an antimitotic drug to activated lymphoma cells

(2010) Stephen M Ansell   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Bioinspired Total Synthesis and Human Proteasome Inhibitory Activity of (−)-Salinosporamide A, (−)-Homosalinosporamide A, and Derivatives Obtained via Organonucleophile Promoted Bis-cyclizations

(2010) Henry Nguyen et al.   JOURNAL OF ORGANIC CHEMISTRY

Marine Antitumor Drugs: Status, Shortfalls and Strategies

(2010) Ira Bhatnagar et al.   Marine Drugs

Molecular pharmacology and antitumor activity of Zalypsis ® in several human cancer cell lines

(2009) Juan F.M. Leal et al.   BIOCHEMICAL PHARMACOLOGY

Function-Oriented Biosynthesis of β-Lactone Proteasome Inhibitors inSalinispora tropica

(2009) Markus Nett et al.   JOURNAL OF MEDICINAL CHEMISTRY

χ-Conopeptide Pharmacophore Development: Toward a Novel Class of Norepinephrine Transporter Inhibitor (Xen2174) for Pain⊥

(2009) Andreas Brust et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of Yondelis® (trabectedin, ET-743). A semisynthetic process solves the supply problem

(2009) Carmen Cuevas et al.   NATURAL PRODUCT REPORTS

Discovery and development of the anticancer agent salinosporamide A (NPI-0052)

(2008) William Fenical et al.   BIOORGANIC & MEDICINAL CHEMISTRY