Natural products and Pharma 2011: Strategic changes spur new opportunities

Eribulin mesylate

(2011) Timothy K. Huyck et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

(2011) L. Laureti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation

(2010) Yihua Chen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The Discovery of Salinosporamide K from the Marine Bacterium “Salinispora pacifica” by Genome Mining Gives Insight into Pathway Evolution

(2010) Alessandra S. Eustáquio et al.   CHEMBIOCHEM

Genome mining for ribosomally synthesized natural products

(2010) Juan E Velásquez et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Natural Products Version 2.0: Connecting Genes to Molecules

(2010) Christopher T. Walsh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes

(2010) G. P. Horsman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered Streptomyces platensis Strains That Overproduce Antibiotics Platensimycin and Platencin

(2009) M. J. Smanski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibody−Drug Conjugates: Linking Cytotoxic Payloads to Monoclonal Antibodies

(2009) Laurent Ducry et al.   BIOCONJUGATE CHEMISTRY

Recent advances in the chemistry, biosynthesis and pharmacology of rapamycin analogs

(2009) Edmund I. Graziani   NATURAL PRODUCT REPORTS

Pharmaceutical industry financial performance

(2009) Michael Goodman   NATURE REVIEWS DRUG DISCOVERY

Optimizing Natural Products by Biosynthetic Engineering: Discovery of Nonquinone Hsp90 Inhibitors†

(2008) Ming-Qiang Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pre-fractionated Microbial Samples – The Second Generation Natural Products Library at Wyeth

(2008) Melissa Wagenaar   MOLECULES

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY

Function-Oriented Synthesis, Step Economy, and Drug Design

(2007) Paul A. Wender et al.   ACCOUNTS OF CHEMICAL RESEARCH