Purification and Identification of Activating Enzymes of CS-0777, a Selective Sphingosine 1-Phosphate Receptor 1 Modulator, in Erythrocytes

Discovery of CS-0777: A Potent, Selective, and Orally Active S1P1 Agonist

(2011) Takahide Nishi et al.   ACS Medicinal Chemistry Letters

Fingolimod for relapsing multiple sclerosis: an update

(2010) Alejandro Horga et al.   EXPERT OPINION ON PHARMACOTHERAPY

Human Carboxymethylenebutenolidase as a Bioactivating Hydrolase of Olmesartan Medoxomil in Liver and Intestine

(2010) Tomoko Ishizuka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Sphingosine 1-Phosphate Transporter, SPNS2, Functions as a Transporter of the Phosphorylated Form of the Immunomodulating Agent FTY720

(2010) Yu Hisano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

(2010) Jeffrey A. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characterization of the ATP-dependent Sphingosine 1-Phosphate Transporter in Rat Erythrocytes

(2009) Naoki Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ketoconazole Increases Fingolimod Blood Levels in a Drug Interaction via CYP4F2 Inhibition

(2009) John M. Kovarik et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Sensitive multiplexed analysis of kinase activities and activity-based kinase identification

(2009) Kazuishi Kubota et al.   NATURE BIOTECHNOLOGY

Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules

(2009) David Marsolais et al.   NATURE REVIEWS DRUG DISCOVERY

Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720

(2008) A KIHARA   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors

(2008) A. Kawahara et al.   SCIENCE