Fidaxomicin Is an Inhibitor of the Initiation of Bacterial RNA Synthesis

Mechanism of Bacterial Transcription Initiation: RNA Polymerase - Promoter Binding, Isomerization to Initiation-Competent Open Complexes, and Initiation of RNA Synthesis

(2011) Ruth M. Saecker et al.   JOURNAL OF MOLECULAR BIOLOGY

The transcription inhibitor lipiarmycin blocks DNA fitting into the RNA polymerase catalytic site

(2010) Audrey Tupin et al.   EMBO JOURNAL

Allosteric control of Escherichia coli rRNA promoter complexes by DksA

(2009) S. T. Rutherford et al.   GENES & DEVELOPMENT

Molecular Evolution of Multisubunit RNA Polymerases: Structural Analysis

(2009) William J. Lane et al.   JOURNAL OF MOLECULAR BIOLOGY

The RNA Polymerase “Switch Region” Is a Target for Inhibitors

(2008) Jayanta Mukhopadhyay et al.   CELL

Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis

(2008) M. Kurabachew et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Transcription inactivation through local refolding of the RNA polymerase structure

(2008) Georgiy A. Belogurov et al.   NATURE