Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms

Derivatization of (5R)-hydroxytriptolide from benzylamine to enhance mass spectrometric detection: Application to a Phase I pharmacokinetic study in humans

(2011) Jia Liu et al.   ANALYTICA CHIMICA ACTA

Triptolide augments the effects of 5-lipoxygenase RNA interference in suppressing pancreatic tumor growth in a xenograft mouse model

(2011) Xiaoling Ding et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Triptolide Directly Inhibits dCTP Pyrophosphatase

(2011) Timothy W. Corson et al.   CHEMBIOCHEM

Complexity of dendritic cell subsets and their function in the host immune system

(2011) Rahul Kushwah et al.   IMMUNOLOGY

Triptolide and its expanding multiple pharmacological functions

(2011) Qiuyan Liu   INTERNATIONAL IMMUNOPHARMACOLOGY

MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML

(2011) B Z Carter et al.   LEUKEMIA

XPB, a subunit of TFIIH, is a target of the natural product triptolide

(2011) Denis V Titov et al.   Nature Chemical Biology

Total synthesis of novel D-ring-modified triptolide analogues: structure–cytotoxic activity relationship studies on the D-ring of triptolide

(2011) Bing Zhou et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Triptolide (TPL) Inhibits Global Transcription by Inducing Proteasome-Dependent Degradation of RNA Polymerase II (Pol II)

(2011) Ying Wang et al.   PLoS One

Effects of triptolide on RIZ1 expression, proliferation and apoptosis in multiple myeloma U266 cells

(2010) Fei Zhao et al.   ACTA PHARMACOLOGICA SINICA

Design, synthesis, and biological evaluation of novel water-soluble triptolide derivatives: Antineoplastic activity against imatinib-resistant CML cells bearing T315I mutant Bcr-Abl

(2010) Fang Xu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel triptolide analogues for anticancer activity

(2010) Bing Zhou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells

(2010) Ramani Soundararajan et al.   CANCER BIOLOGY & THERAPY

RETRACTED: Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer cells

(2010) Haili Li et al.   CANCER LETTERS

RNA polymerase – An important molecular target of triptolide in cancer cells

(2010) Jingxuan Pan   CANCER LETTERS

Diastereoselective formal total synthesis of (±)-triptolide via a novel cationic cyclization of 2-alkenyl-1,3-dithiolane

(2010) Sylvie Goncalves et al.   CHEMICAL COMMUNICATIONS

Report of 12 cases of ankylosing spondylitis patients treated with Tripterygium wilfordii

(2010) Wei Ji et al.   CLINICAL RHEUMATOLOGY

Role of triptolide in cell proliferation, cell cycle arrest, apoptosis and histone methylation in multiple myeloma U266 cells

(2010) Fei Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Triptolide Induces Cell Death in Pancreatic Cancer Cells by Apoptotic and Autophagic Pathways

(2010) Nameeta Mujumdar et al.   GASTROENTEROLOGY

Triptolide promotes spinal cord repair by inhibiting astrogliosis and inflammation

(2010) Zhida Su et al.   GLIA

Meta-Analysis of Tripterygium Wilfordii Hook F in the Immunosuppressive Treatment of IgA Nephropathy

(2010) Yi-Zhi Chen et al.   INTERNAL MEDICINE

Triptolide and TRAIL Combination Enhances Apoptosis in Cholangiocarcinoma

(2010) Kimberly A. Clawson et al.   JOURNAL OF SURGICAL RESEARCH

Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9-induced podocyte injury in vitro

(2010) Zhao-Hong Chen et al.   KIDNEY INTERNATIONAL

Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide

(2010) Zhao-Li Zhou et al.   Molecular Cancer

Triptolide ameliorates IL-10-deficient mice colitis by mechanisms involving suppression of IL-6/STAT3 signaling pathway and down-regulation of IL-17

(2010) Yi Li et al.   MOLECULAR IMMUNOLOGY

Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD

(2010) S. J. Leuenroth et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Efficient synthesis of the key intermediate triptophenolide methyl ether for the synthesis of (−)-triptolide

(2010) Bing Zhou et al.   TETRAHEDRON

Triptolide inhibits Jak2 transcription and induces apoptosis in human myeloproliferative disorder cells bearing Jak2V617F through caspase-3-mediated cleavage of Mcl-1

(2009) Qi Chen et al.   CANCER LETTERS

Triptolide Inhibits Bcr-Abl Transcription and Induces Apoptosis in STI571-resistant Chronic Myelogenous Leukemia Cells Harboring T315I Mutation

(2009) X. Shi et al.   CLINICAL CANCER RESEARCH

Phase I dose-escalation study of F60008, a novel apoptosis inducer, in patients with advanced solid tumours

(2009) J.J.E.M. Kitzen et al.   EUROPEAN JOURNAL OF CANCER

Alternative activation of macrophages: Immune function and cellular biology

(2009) Audrey Varin et al.   IMMUNOBIOLOGY

Design and Synthesis of Novel C14-Hydroxyl Substituted Triptolide Derivatives as Potential Selective Antitumor Agents

(2009) Zheng Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-κB/IκBα transcriptional complex

(2009) Pablo Kizelsztein et al.   JOURNAL OF NEUROIMMUNOLOGY

Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA

(2009) S. Vispe et al.   MOLECULAR CANCER THERAPEUTICS

A Small-Molecule Triptolide Suppresses Angiogenesis and Invasion of Human Anaplastic Thyroid Carcinoma Cells via Down-Regulation of the Nuclear Factor- B Pathway

(2009) W. Zhu et al.   MOLECULAR PHARMACOLOGY

Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo

(2009) Yuan-Wu Chen et al.   ORAL ONCOLOGY

Effects of triptolide from Tripterygium wilfordii on ERα and p53 expression in two human breast cancer cell lines

(2009) Jing Liu et al.   PHYTOMEDICINE

Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo

(2009) Mara B. Antonoff et al.   SURGERY

Triptolide alters histone H3K9 and H3K27 methylation state and induces G0/G1 arrest and caspase-dependent apoptosis in multiple myeloma in vitro

(2009) Fei Zhao et al.   TOXICOLOGY

Anti-angiogenic activity of triptolide in anaplastic thyroid carcinoma is mediated by targeting vascular endothelial and tumor cells

(2009) Wenbo Zhu et al.   VASCULAR PHARMACOLOGY

Effects of triptolide from Radix Tripterygium wilfordii (Leigongteng) on cartilage cytokines and transcription factor NF-κB: a study on induced arthritis in rats

(2009) Cheng Xiao et al.   Chinese Medicine

Effective therapy for nephritis in (NZB × NZW)F1 mice with triptolide and tripdiolide, the principal active components of the Chinese herbal remedyTripterygium wilfordii Hook F

(2008) Xuelian Tao et al.   ARTHRITIS AND RHEUMATISM

Fluorination of triptolide and its analogues and their cytotoxicity

(2008) Yutaka Aoyagi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5

(2008) B. Z. Carter et al.   BLOOD

Triptolide-Induced Transcriptional Arrest Is Associated with Changes in Nuclear Substructure

(2008) S. J. Leuenroth et al.   CANCER RESEARCH

Formal total synthesis of triptolide

(2008) Natalie A. Miller et al.   CHEMICAL COMMUNICATIONS

The suppressive effect of triptolide on chronic colitis and TNF-α/TNFR2 signal pathway in interleukin-10 deficient mice

(2008) Xiaowei Wei et al.   CLINICAL IMMUNOLOGY

Differential effects of triptolide and tetrandrine on activation of COX-2, NF-κB, and AP-1 and virus production in dengue virus-infected human lung cells

(2008) Jun-Ting Liou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibitory effect of triptolide on interleukin-18 and its receptor in rheumatoid arthritis synovial fibroblasts

(2008) Y. Lu et al.   INFLAMMATION RESEARCH

Antiangiogenic activity of Tripterygium wilfordii and its terpenoids

(2008) Ming-Fang He et al.   JOURNAL OF ETHNOPHARMACOLOGY

Triptolide modulates T-cell inflammatory responses and ameliorates experimental autoimmune encephalomyelitis

(2008) Ying Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Triptolide Reduces Cystogenesis in a Model of ADPKD

(2008) S. J. Leuenroth et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Triptolide Inhibits the Differentiation of Th17 cells and Suppresses Collagen-induced Arthritis

(2008) Y. Wang et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Prolongation of Rat Intestinal Allograft Survival by Administration of Triptolide-Modified Donor Bone Marrow-Derived Dendritic Cells

(2008) T. Chen et al.   TRANSPLANTATION PROCEEDINGS