Role of Optineurin in the Mitochondrial Dysfunction: Potential Implications in Neurodegenerative Diseases and Cancer

The genetics of Parkinson disease

(2018) Hao Deng et al.   AGEING RESEARCH REVIEWS

Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation

(2018) Thomas Goiran et al.   CELL DEATH AND DIFFERENTIATION

Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria

(2018) Antonina J. Kruppa et al.   DEVELOPMENTAL CELL

Mitophagy in neurodegenerative diseases

(2018) Carlo Rodolfo et al.   NEUROCHEMISTRY INTERNATIONAL

Optineurin-mediated mitophagy protects renal tubular epithelial cells against accelerated senescence in diabetic nephropathy

(2018) Kehong Chen et al.   Cell Death & Disease

Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis

(2017) Anna S. Gukovskaya et al.   GASTROENTEROLOGY

HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo

(2017) Dagmar E Ehrnhoefer et al.   HUMAN MOLECULAR GENETICS

Mitochondrial fission facilitates the selective mitophagy of protein aggregates

(2017) Jonathon L. Burman et al.   JOURNAL OF CELL BIOLOGY

Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells

(2017) Kai Liu et al.   MOLECULAR CELL

Cytosolic proteostasis through importing of misfolded proteins into mitochondria

(2017) Linhao Ruan et al.   NATURE

The role of mitochondria in amyotrophic lateral sclerosis

(2017) Emma F. Smith et al.   NEUROSCIENCE LETTERS

Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasis

(2017) T C Kenny et al.   ONCOGENE

Optineurin in amyotrophic lateral sclerosis: Multifunctional adaptor protein at the crossroads of different neuroprotective mechanisms

(2017) Andrea Markovinovic et al.   PROGRESS IN NEUROBIOLOGY

Methylation of BNIP3 in pancreatic cancer inhibits the induction of mitochondrial-mediated tumor cell apoptosis

(2017) Ye Li et al.   Oncotarget

CSFV induced mitochondrial fission and mitophagy to inhibit apoptosis

(2017) Hongchao Gou et al.   Oncotarget

TBK1: a new player in ALS linking autophagy and neuroinflammation

(2017) James A. Oakes et al.   Molecular Brain

Chemoresistance of colorectal cancer to 5-fluorouracil is associated with silencing of the BNIP3 gene through aberrant methylation

(2017) Jianming He et al.   Journal of Cancer

TBK1 Promote Bladder Cancer Cell Proliferation and Migration via Akt Signaling

(2017) Wei Chen et al.   Journal of Cancer

Neuronal Mitophagy in Neurodegenerative Diseases

(2017) Marta Martinez-Vicente   Frontiers in Molecular Neuroscience

The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond

(2017) Timothy C. Kenny et al.   Frontiers in Oncology

Spatiotemporal dynamics of autophagy receptors in selective mitophagy

(2016) Andrew S. Moore et al.   Autophagy

PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma

(2016) S. Agnihotri et al.   CANCER RESEARCH

Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment

(2016) Zhenyu Zhong et al.   CELL

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

AMPK Promotes Autophagy by Facilitating Mitochondrial Fission

(2016) Chen-Song Zhang et al.   Cell Metabolism

Regulation of TBK1 activity by Optineurin contributes to cell cycle-dependent expression of the interferon pathway

(2016) Robert Weil et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling

(2016) Karolina Slowicka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The PINK1, synphilin-1 and SIAH-1 complex constitutes a novel mitophagy pathway

(2016) Raymonde Szargel et al.   HUMAN MOLECULAR GENETICS

Metabolic regulation of mitochondrial dynamics

(2016) Prashant Mishra et al.   JOURNAL OF CELL BIOLOGY

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

(2016) Marco Sciacovelli et al.   NATURE

Mutational analysis of TBK1 in Taiwanese patients with amyotrophic lateral sclerosis

(2016) Pei-Chien Tsai et al.   NEUROBIOLOGY OF AGING

Urinary LRRK2 phosphorylation

(2016) Anne Grünewald et al.   NEUROLOGY

OPTN691_692insAG is a founder mutation causing recessive ALS and increased risk in heterozygotes

(2016) Orly Goldstein et al.   NEUROLOGY

Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

(2016) Benjamin Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy

(2016) Andrew S. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From the Cover: Alterations in Optineurin Expression and Localization in Pre-clinical Parkinson’s Disease Models

(2016) John Pierce Wise et al.   TOXICOLOGICAL SCIENCES

Deciphering the Molecular Signals of PINK1/Parkin Mitophagy

(2016) Thanh N. Nguyen et al.   TRENDS IN CELL BIOLOGY

Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis

(2016) Seshiru Nakazawa et al.   Nature Communications

Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration

(2016) Myoung Sup Shim et al.   Scientific Reports

The receptor proteins: pivotal roles in selective autophagy

(2015) Zhijie Xu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease

(2015) Cyril Pottier et al.   ACTA NEUROPATHOLOGICA

Copy Number Variations of TBK1 in Australian Patients With Primary Open-Angle Glaucoma

(2015) Mona S. Awadalla et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Deubiquitinating enzymes regulate PARK2-mediated mitophagy

(2015) Yuqing Wang et al.   Autophagy

Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts

(2015) Jon Sin et al.   Autophagy

Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2

(2015) Xingqiao Xie et al.   Autophagy

Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy

(2015) Matthildi Valianou et al.   CELL CYCLE

Autophagy Mediates Tolerance to Staphylococcus aureus Alpha-Toxin

(2015) Katie Maurer et al.   Cell Host & Microbe

ID: 20

(2015) Pierre Génin et al.   CYTOKINE

Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis

(2015) T. S. Chew et al.   Disease Models & Mechanisms

Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis

(2015) A. Kumar et al.   EMBO JOURNAL

A Ubl/ubiquitin switch in the activation of Parkin

(2015) V. Sauve et al.   EMBO JOURNAL

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis

(2015) A. H. Chourasia et al.   EMBO REPORTS

Phosphorylation of ubiquitin at Ser65 affects its polymerization, targets, and proteome-wide turnover

(2015) D. L. Swaney et al.   EMBO REPORTS

TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation

(2015) Gen Matsumoto et al.   HUMAN MOLECULAR GENETICS

The E3 Ubiquitin Ligase Parkin Is Recruited to the 26 S Proteasome via the Proteasomal Ubiquitin Receptor Rpn13

(2015) Miguel A. Aguileta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation

(2015) Koji Yamano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylated ubiquitin chain is the genuine Parkin receptor

(2015) Kei Okatsu et al.   JOURNAL OF CELL BIOLOGY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Apoptosis, autophagy, necroptosis, and cancer metastasis

(2015) Zhenyi Su et al.   Molecular Cancer

Measuring In Vivo Mitophagy

(2015) Nuo Sun et al.   MOLECULAR CELL

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

(2015) Jin-Mi Heo et al.   MOLECULAR CELL

Mechanism of phospho-ubiquitin-induced PARKIN activation

(2015) Tobias Wauer et al.   NATURE

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria

(2015) Christian N. Cunningham et al.   NATURE CELL BIOLOGY

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

(2015) Axel Freischmidt et al.   NATURE NEUROSCIENCE

Mutation analysis of MATR3 in Australian familial amyotrophic lateral sclerosis

(2015) Jennifer A. Fifita et al.   NEUROBIOLOGY OF AGING

The distinct genetic pattern of ALS in Turkey and novel mutations

(2015) Aslıhan Özoğuz et al.   NEUROBIOLOGY OF AGING

Novel TBK1 truncating mutation in a familial amyotrophic lateral sclerosis patient of Chinese origin

(2015) Kelly L. Williams et al.   NEUROBIOLOGY OF AGING

Investigation of next-generation sequencing technologies as a diagnostic tool for amyotrophic lateral sclerosis

(2015) Sarah Morgan et al.   NEUROBIOLOGY OF AGING

Loss ofTBK1is a frequent cause of frontotemporal dementia in a Belgian cohort

(2015) Ilse Gijselinck et al.   NEUROLOGY

Oligogenic inheritance of optineurin (OPTN) andC9ORF72mutations in ALS highlights localisation of OPTN in the TDP-43-negative inclusions ofC9ORF72-ALS

(2015) Joanna J. Bury et al.   NEUROPATHOLOGY

Targeting Pink1-Parkin-mediated mitophagy for treating liver injury

(2015) Jessica A. Williams et al.   PHARMACOLOGICAL RESEARCH

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

(2015) E. T. Cirulli et al.   SCIENCE

Connecting Mitochondria, Metabolism, and Stem Cell Fate

(2015) Anaïs Wanet et al.   STEM CELLS AND DEVELOPMENT

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

(2015) Brent J. Ryan et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Dutch family with autosomal recessively inherited lower motor neuron predominant motor neuron disease due to optineurin mutations

(2015) Emma Beeldman et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Optineurin mutations in patients with sporadic amyotrophic lateral sclerosis in China

(2015) Chengyu Li et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagy

(2015) Bettina Wurzer et al.   eLife

Determinants and Functions of Mitochondrial Behavior

(2014) Katherine Labbé et al.   Annual Review of Cell and Developmental Biology

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

(2014) Agne Kazlauskaite et al.   BIOCHEMICAL JOURNAL

Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression

(2014) Zhengzhao Liu et al.   CANCER CELL

A new pathway for mitochondrial quality control: mitochondrial-derived vesicles

(2014) A. Sugiura et al.   EMBO JOURNAL

USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin

(2014) T. M. Durcan et al.   EMBO JOURNAL

Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control

(2014) Gian-Luca McLelland et al.   EMBO JOURNAL

PINK1 and Parkin - mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease

(2014) Agne Kazlauskaite et al.   FEBS Journal

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy

(2014) Tom Cornelissen et al.   HUMAN MOLECULAR GENETICS

Disruption of macrophage pro-inflammatory cytokine release in Crohn's disease is associated with reduced optineurin expression in a subset of patients

(2014) Andrew M. Smith et al.   IMMUNOLOGY

Solution Structure of the Ubiquitin-associated (UBA) Domain of Human Autophagy Receptor NBR1 and Its Interaction with Ubiquitin and Polyubiquitin

(2014) Erik Walinda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 Kinase Catalytic Activity Is Regulated by Phosphorylation on Serines 228 and 402

(2014) Liesbeth Aerts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial fusion is frequent in skeletal muscle and supports excitation–contraction coupling

(2014) Verónica Eisner et al.   JOURNAL OF CELL BIOLOGY

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

Mitophagy Enhances Oncolytic Measles Virus Replication by Mitigating DDX58/RIG-I-Like Receptor Signaling

(2014) M. Xia et al.   JOURNAL OF VIROLOGY

Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis

(2014) Alban Ordureau et al.   MOLECULAR CELL

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

(2014) Baris Bingol et al.   NATURE

Extensive molecular genetic survey of Taiwanese patients with amyotrophic lateral sclerosis

(2014) Bing-Wen Soong et al.   NEUROBIOLOGY OF AGING

The Parkinson’s gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypes

(2014) C H O'Flanagan et al.   ONCOGENE

E50K-OPTN-Induced Retinal Cell Death Involves the Rab GTPase-Activating Protein, TBC1D17 Mediated Block in Autophagy

(2014) Madhavi Latha Somaraju Chalasani et al.   PLoS One

Oligomerization of Optineurin and Its Oxidative Stress- or E50K Mutation-Driven Covalent Cross-Linking: Possible Relationship with Glaucoma Pathology

(2014) Jie Gao et al.   PLoS One

Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistence

(2014) S.-J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy

(2014) J. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

(2014) Yvette C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of the Selective Adaptor p62 and Ubiquitin-Like Proteins in Autophagy

(2014) Mónika Lippai et al.   Biomed Research International

Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy

(2014) Koji Yamano et al.   eLife

TBK1Gene Duplication and Normal-Tension Glaucoma

(2014) Robert Ritch et al.   JAMA Ophthalmology

Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro

(2013) Liang Zhou et al.   ACTA PHARMACOLOGICA SINICA

M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells

(2013) Kapil Sirohi et al.   Autophagy

Structural basis for phosphorylation-triggered autophagic clearance ofSalmonella

(2013) Vladimir V. Rogov et al.   BIOCHEMICAL JOURNAL

Rheb Regulates Mitophagy Induced by Mitochondrial Energetic Status

(2013) Su Melser et al.   Cell Metabolism

Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism

(2013) Xinde Zheng et al.   CELL RESEARCH

Structure of the human Parkin ligase domain in an autoinhibited state

(2013) Tobias Wauer et al.   EMBO JOURNAL

Phosphorylation of mitophagy and pexophagy receptors coordinates their interaction with Atg8 and Atg11

(2013) Jean-Claude Farré et al.   EMBO REPORTS

Recent insights into the complexity of Tank-binding kinase 1 signaling networks: The emerging role of cellular localization in the activation and substrate specificity of TBK1

(2013) Elizabeth Helgason et al.   FEBS LETTERS

Association Between Variants of PRDM1 and NDP52 and Crohn's Disease, Based on Exome Sequencing and Functional Studies

(2013) David Ellinghaus et al.   GASTROENTEROLOGY

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

A Dimeric PINK1-containing Complex on Depolarized Mitochondria Stimulates Parkin Recruitment

(2013) Kei Okatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation

(2013) Masahiro Iguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

(2013) Michael Lazarou et al.   JOURNAL OF CELL BIOLOGY

Myosin VI and its cargo adaptors - linking endocytosis and autophagy

(2013) D. A. Tumbarello et al.   JOURNAL OF CELL SCIENCE

Optineurin Insufficiency Impairs IRF3 but Not NF- B Activation in Immune Cells

(2013) I. Munitic et al.   JOURNAL OF IMMUNOLOGY

Delineating the genetic heterogeneity of ALS using targeted high-throughput sequencing

(2013) Kevin P Kenna et al.   JOURNAL OF MEDICAL GENETICS

Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells

(2013) Junghyung Park et al.   JOURNAL OF NEUROCHEMISTRY

The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO

(2013) Anne Kathrin Müller-Rischart et al.   MOLECULAR CELL

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

The genetic landscape of high-risk neuroblastoma

(2013) Trevor J Pugh et al.   NATURE GENETICS

Clinicopathologic features of autosomal recessive amyotrophic lateral sclerosis associated with optineurin mutation

(2013) Masaki Kamada et al.   NEUROPATHOLOGY

Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells

(2013) J.-Y. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

(2013) J.-F. Trempe et al.   SCIENCE

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

Sterical Hindrance Promotes Selectivity of the Autophagy Cargo Receptor NDP52 for the Danger Receptor Galectin-8 in Antibacterial Autophagy

(2013) S. Li et al.   Science Signaling

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

(2013) B.E. Riley et al.   Nature Communications

Structural basis for recognition of autophagic receptor NDP52 by the sugar receptor galectin-8

(2013) Byeong-Won Kim et al.   Nature Communications

Hepatitis B Virus Disrupts Mitochondrial Dynamics: Induces Fission and Mitophagy to Attenuate Apoptosis

(2013) Seong-Jun Kim et al.   PLoS Pathogens

Mutational analysis of familial and sporadic amyotrophic lateral sclerosis withOPTNmutations in Japanese population

(2012) Hiroya Naruse et al.   Amyotrophic Lateral Sclerosis

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Mitochondrial hexokinase HKI is a novel substrate of the Parkin ubiquitin ligase

(2012) Kei Okatsu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A role for sequestosome 1/p62 in mitochondrial dynamics, import and genome integrity

(2012) M. Lamar Seibenhener et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Toward an integrative view of Optineurin functions

(2012) David Kachaner et al.   CELL CYCLE

The LRR and RING Domain Protein LRSAM1 Is an E3 Ligase Crucial for Ubiquitin-Dependent Autophagy of Intracellular Salmonella Typhimurium

(2012) Alan Huett et al.   Cell Host & Microbe

Regulation of NF-κB signaling by the A20 deubiquitinase

(2012) Noula Shembade et al.   Cellular & Molecular Immunology

Oxidative stress and mitochondrial dysfunction in glaucoma

(2012) Vicki Chrysostomou et al.   CURRENT OPINION IN PHARMACOLOGY

Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin

(2012) Michael Lazarou et al.   DEVELOPMENTAL CELL

Mouse lines with photo-activatable mitochondria to study mitochondrial dynamics

(2012) Anh H. Pham et al.   GENESIS

Regulation of NF-κB by deubiquitinases

(2012) Edward W. Harhaj et al.   IMMUNOLOGICAL REVIEWS

Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy

(2012) E. Itakura et al.   JOURNAL OF CELL SCIENCE

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

(2012) J. Korac et al.   JOURNAL OF CELL SCIENCE

Mitochondria and cell signalling

(2012) Stephen W. G. Tait et al.   JOURNAL OF CELL SCIENCE

The axonal transport of mitochondria

(2012) W. M. Saxton et al.   JOURNAL OF CELL SCIENCE

Essential Role for the Mammalian ATG8 Isoform LC3C in Xenophagy

(2012) Tomer Shpilka et al.   MOLECULAR CELL

Plk1-Dependent Phosphorylation of Optineurin Provides a Negative Feedback Mechanism for Mitotic Progression

(2012) David Kachaner et al.   MOLECULAR CELL

Fluorescence-Based Sensors to Monitor Localization and Functions of Linear and K63-Linked Ubiquitin Chains in Cells

(2012) Sjoerd J.L. van Wijk et al.   MOLECULAR CELL

Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling

(2012) Joshua J Sims et al.   NATURE METHODS

Novel deletion mutations of OPTN in amyotrophic lateral sclerosis in Japanese

(2012) Aritoshi Iida et al.   NEUROBIOLOGY OF AGING

A novel optineurin truncating mutation and three glaucoma-associated missense variants in patients with familial amyotrophic lateral sclerosis in Germany

(2012) Jochen H. Weishaupt et al.   NEUROBIOLOGY OF AGING

Contribution of major amyotrophic lateral sclerosis genes to the etiology of sporadic disease

(2012) S. Lattante et al.   NEUROLOGY

Extensive genetics of ALS: A population-based study in Italy

(2012) A. Chio et al.   NEUROLOGY

Genetic Overlap between Apparently Sporadic Motor Neuron Diseases

(2012) Marka van Blitterswijk et al.   PLoS One

Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism

(2012) D. Narendra et al.   Cold Spring Harbor Perspectives in Biology

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Optineurin is co-localized with FUS in basophilic inclusions of ALS with FUS mutation and in basophilic inclusion body disease

(2011) Hidefumi Ito et al.   ACTA NEUROPATHOLOGICA

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

Targeting Mitochondrial Dysfunction: Role for PINK1 and Parkin in Mitochondrial Quality Control

(2011) Derek P. Narendra et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitophagy: A Complex Mechanism of Mitochondrial Removal

(2011) Ivana Novak   ANTIOXIDANTS & REDOX SIGNALING

Involvement of mitophagy in oncogenic K-Ras-induced transformation

(2011) June-Hyung Kim et al.   Autophagy

The ubiquitin-binding adaptor proteins p62/SQSTM1 and NDP52 are recruited independently to bacteria-associated microdomains to target Salmonella to the autophagy pathway

(2011) Marija Cemma et al.   Autophagy

Novel cross-talk within the IKK family controls innate immunity

(2011) Kristopher Clark et al.   BIOCHEMICAL JOURNAL

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

(2011) Xinnan Wang et al.   CELL

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

(2011) Fajian Hou et al.   CELL

Mitochondrial ROS fuel the inflammasome

(2011) Matthew T Sorbara et al.   CELL RESEARCH

Diabetes and Risk of Parkinson's Disease

(2011) Q. Xu et al.   DIABETES CARE

Autoregulation of Parkin activity through its ubiquitin-like domain

(2011) Viduth K Chaugule et al.   EMBO JOURNAL

Molecular genetics in glaucoma

(2011) Yutao Liu et al.   EXPERIMENTAL EYE RESEARCH

Primary open-angle glaucoma genes

(2011) J H Fingert   EYE

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

(2011) Nickie C. Chan et al.   HUMAN MOLECULAR GENETICS

Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production

(2011) Shitao Li et al.   IMMUNITY

Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane

(2011) Saori R. Yoshii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics of the Degradation of Ubiquitinated Proteins by Proteasomes and Autophagy

(2011) Natura Myeku et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon β

(2011) Catherine E. Gleason et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62 and NDP52 Proteins Target IntracytosolicShigellaandListeriato Different Autophagy Pathways

(2011) Serge Mostowy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel optineurin mutations in patients with familial and sporadic amyotrophic lateral sclerosis

(2011) R. Del Bo et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Optineurin mutations in Japanese amyotrophic lateral sclerosis: Table 1

(2011) Aritoshi Iida et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

(2011)   LANCET

Screening of OPTN in French familial amyotrophic lateral sclerosis

(2011) Stéphanie Millecamps et al.   NEUROBIOLOGY OF AGING

A novel heterozygous nonsense mutation of the OPTN gene segregating in a Danish family with ALS

(2011) Zeynep Tümer et al.   NEUROBIOLOGY OF AGING

Optineurin in neurodegenerative diseases

(2011) Tenshi Osawa et al.   NEUROPATHOLOGY

Optineurin in Huntington's disease intranuclear inclusions

(2011) Claudia Schwab et al.   NEUROSCIENCE LETTERS

Optineurin Is Required for CYLD-Dependent Inhibition of TNFα-Induced NF-κB Activation

(2011) Ananthamurthy Nagabhushana et al.   PLoS One

Mitochondrial dysfunction in ALS

(2011) Mauro Cozzolino et al.   PROGRESS IN NEUROBIOLOGY

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

Degradation of Paternal Mitochondria by Fertilization-Triggered Autophagy in C. elegans Embryos

(2011) M. Sato et al.   SCIENCE

Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission

(2011) S. Al Rawi et al.   SCIENCE

TAX1BP1, a ubiquitin-binding adaptor protein in innate immunity and beyond

(2011) Lynn Verstrepen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Oncosuppressive Functions of Autophagy

(2010) Eugenia Morselli et al.   ANTIOXIDANTS & REDOX SIGNALING

Uncovering the roles of PINK1 and Parkin in mitophagy

(2010) Noriyuki Matsuda et al.   Autophagy

Nix: A receptor protein for mitophagy in mammals

(2010) Tomotake Kanki   Autophagy

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

(2010) Derek Narendra et al.   Autophagy

The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

(2010) Sven Geisler et al.   Autophagy

p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

(2010) Kei Okatsu et al.   GENES TO CELLS

Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice

(2010) Zai-Long Chi et al.   HUMAN MOLECULAR GENETICS

Processing of Optineurin in Neuronal Cells

(2010) Xiang Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TAX1BP1 and A20 Inhibit Antiviral Signaling by Targeting TBK1-IKKi Kinases

(2010) Kislay Parvatiyar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Phosphorylation of p62 by cdk1 Controls the Timely Transit of Cells through Mitosis and Tumor Cell Proliferation

(2010) J. F. Linares et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutations of optineurin in amyotrophic lateral sclerosis

(2010) Hirofumi Maruyama et al.   NATURE

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Analysis of OPTN as a causative gene for amyotrophic lateral sclerosis

(2010) Véronique V. Belzil et al.   NEUROBIOLOGY OF AGING

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

NBR1 co-operates with p62 in selective autophagy of ubiquitinated targets

(2009) Vladimir Kirkin et al.   Autophagy

Expression of BNIP3 in invasive breast cancer: correlations with the hypoxic response and clinicopathological features

(2009) Esther A Koop et al.   BMC CANCER

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

(2009) Jorge Moscat et al.   CELL

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

RBR Ubiquitin Ligases: Diversification and Streamlining in Animal Lineages

(2009) Ignacio Marín   JOURNAL OF MOLECULAR EVOLUTION

Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice

(2009) Tohru Kitada et al.   JOURNAL OF NEUROCHEMISTRY

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

(2009) Teresa L M Thurston et al.   NATURE IMMUNOLOGY

Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little?

(2009) Kurt M. Lucin et al.   NEURON

Lack of Association Between Optineurin Gene Variants T34T, E50K, M98K, 691_692insAG and R545Q and Primary Open Angle Glaucoma in Brazilian Patients

(2009) Cristiano Caixeta-Umbelino et al.   OPHTHALMIC GENETICS

Optineurin and Its Mutants: Molecules Associated with Some Forms of Glaucoma

(2009) Madhavi Latha Chalasani et al.   OPHTHALMIC RESEARCH

NF-κB Mediates Tumor Necrosis Factor α-Induced Expression of Optineurin, a Negative Regulator of NF-κB

(2009) Cherukuri Sudhakar et al.   PLoS One

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

Huntingtin as an essential integrator of intracellular vesicular trafficking

(2009) Juliane P. Caviston et al.   TRENDS IN CELL BIOLOGY

Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view

(2008) Gilad Twig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis

(2008) Angeles Duran et al.   CANCER CELL

Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-κB activation

(2008) Hidekatsu Iha et al.   EMBO JOURNAL

The genetics of primary open-angle glaucoma: A review

(2008) R. Rand Allingham et al.   EXPERIMENTAL EYE RESEARCH

Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

(2008) Simon Morton et al.   FEBS LETTERS

Ref(2)P, theDrosophila melanogasterhomologue of mammalian p62, is required for the formation of protein aggregates in adult brain

(2008) Ioannis P. Nezis et al.   JOURNAL OF CELL BIOLOGY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration

(2008) T. C. Frank-Cannon et al.   JOURNAL OF NEUROSCIENCE

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

Parkin as a tumor suppressor gene for hepatocellular carcinoma

(2008) M Fujiwara et al.   ONCOGENE

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE

Proteomic-based approach for biomarkers discovery in early detection of invasive urothelial carcinoma

(2007) Junyu Li et al.   Proteomics Clinical Applications