E50K-OPTN-Induced Retinal Cell Death Involves the Rab GTPase-Activating Protein, TBC1D17 Mediated Block in Autophagy

M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells

(2013) Kapil Sirohi et al.   Autophagy

Enhanced optineurin E50K–TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma

(2013) Yuriko Minegishi et al.   HUMAN MOLECULAR GENETICS

Maturation of autophagosomes and endosomes: A key role for Rab7

(2012) Juha M.T. Hyttinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Toward an integrative view of Optineurin functions

(2012) David Kachaner et al.   CELL CYCLE

Anatomical and functional damage in experimental glaucoma

(2012) M Agudo-Barriuso et al.   CURRENT OPINION IN PHARMACOLOGY

Neuronal autophagy and neurodegenerative diseases

(2012) Jin H. Son et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17

(2012) V. Vaibhava et al.   JOURNAL OF CELL SCIENCE

Plk1-Dependent Phosphorylation of Optineurin Provides a Negative Feedback Mechanism for Mitotic Progression

(2012) David Kachaner et al.   MOLECULAR CELL

Involvement of members of the Rab family and related small GTPases in autophagosome formation and maturation

(2011) Christelle En Lin Chua et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Primary open-angle glaucoma genes

(2011) J H Fingert   EYE

Optineurin in neurodegenerative diseases

(2011) Tenshi Osawa et al.   NEUROPATHOLOGY

Optineurin Is Required for CYLD-Dependent Inhibition of TNFα-Induced NF-κB Activation

(2011) Ananthamurthy Nagabhushana et al.   PLoS One

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant

(2010) Ananthamurthy Nagabhushana et al.   BMC CELL BIOLOGY

Evidence of outer retinal changes in glaucoma patients as revealed by ultrahigh-resolution in vivo retinal imaging

(2010) S. S. Choi et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Changes in the inner and outer retinal layers after acute increase of the intraocular pressure in adult albino Swiss mice

(2010) Nicolás Cuenca et al.   EXPERIMENTAL EYE RESEARCH

Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice

(2010) Zai-Long Chi et al.   HUMAN MOLECULAR GENETICS

Processing of Optineurin in Neuronal Cells

(2010) Xiang Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations of optineurin in amyotrophic lateral sclerosis

(2010) Hirofumi Maruyama et al.   NATURE

Impairment of Protein Trafficking upon Overexpression and Mutation of Optineurin

(2010) BumChan Park et al.   PLoS One

Genetic Bases for Glaucoma

(2010) Nobuo Fuse   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Optineurin Negatively Regulates the Induction of IFNβ in Response to RNA Virus Infection

(2010) Jamel Mankouri et al.   PLoS Pathogens

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Optineurin and Its Mutants: Molecules Associated with Some Forms of Glaucoma

(2009) Madhavi Latha Chalasani et al.   OPHTHALMIC RESEARCH

NF-κB Mediates Tumor Necrosis Factor α-Induced Expression of Optineurin, a Negative Regulator of NF-κB

(2009) Cherukuri Sudhakar et al.   PLoS One

NRP/Optineurin Cooperates with TAX1BP1 to Potentiate the Activation of NF-κB by Human T-Lymphotropic Virus Type 1 Tax Protein

(2009) Chloé Journo et al.   PLoS Pathogens

Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

(2008) Simon Morton et al.   FEBS LETTERS