Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation

Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism

(2013) Xinde Zheng et al.   CELL RESEARCH

Alternative Germ Cell Death Pathway in Drosophila Involves HtrA2/Omi, Lysosomes, and a Caspase-9 Counterpart

(2013) Keren Yacobi-Sharon et al.   DEVELOPMENTAL CELL

Structure of the human Parkin ligase domain in an autoinhibited state

(2013) Tobias Wauer et al.   EMBO JOURNAL

PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

(2013) Michael Lazarou et al.   JOURNAL OF CELL BIOLOGY

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

(2013) J.-F. Trempe et al.   SCIENCE

A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease

(2013) Donald E. Spratt et al.   Nature Communications

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

(2013) B.E. Riley et al.   Nature Communications

Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection

(2013) Jean-François Trempe et al.   Frontiers in Neurology

Mitochondrial hexokinase HKI is a novel substrate of the Parkin ubiquitin ligase

(2012) Kei Okatsu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension

(2012) Judith J Smit et al.   EMBO JOURNAL

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

(2012) Nicole Exner et al.   EMBO JOURNAL

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

(2012) Andrew W Greene et al.   EMBO REPORTS

LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

(2012) Benjamin Stieglitz et al.   EMBO REPORTS

ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons

(2012) Alvin P. Joselin et al.   HUMAN MOLECULAR GENETICS

Phosphatase and Tensin Homolog (PTEN)-induced Putative Kinase 1 (PINK1)-dependent Ubiquitination of Endogenous Parkin Attenuates Mitophagy

(2012) Aleksandar Rakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism

(2012) D. Narendra et al.   Cold Spring Harbor Perspectives in Biology

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

(2012) Kei Okatsu et al.   Nature Communications

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

(2012) Yoichi Imaizumi et al.   Molecular Brain

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

The Yeast Complex I Equivalent NADH Dehydrogenase Rescues pink1 Mutants

(2012) Sven Vilain et al.   PLoS Genetics

Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria

(2012) Song Liu et al.   PLoS Genetics

Regulation of PINK1-Parkin-mediated mitophagy

(2011) Wolfdieter Springer et al.   Autophagy

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

(2011) Xinnan Wang et al.   CELL

Molecular Mechanisms of PINK1-Related Neurodegeneration

(2011) Joe H. Pogson et al.   Current Neurology and Neuroscience Reports

Autoregulation of Parkin activity through its ubiquitin-like domain

(2011) Viduth K Chaugule et al.   EMBO JOURNAL

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

(2011) Nickie C. Chan et al.   HUMAN MOLECULAR GENETICS

Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane

(2011) Saori R. Yoshii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1

(2011) Liliane Glauser et al.   JOURNAL OF NEUROCHEMISTRY

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

(2011) Dawn M. Wenzel et al.   NATURE

What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease

(2011) Olga Corti et al.   PHYSIOLOGICAL REVIEWS

Parkin Mediates Apparent E2-Independent Monoubiquitination In Vitro and Contains an Intrinsic Activity That Catalyzes Polyubiquitination

(2011) Katherine C. M. Chew et al.   PLoS One

Phos-tag SDS-PAGE systems for phosphorylation profiling of proteins with a wide range of molecular masses under neutral pH conditions

(2011) Eiji Kinoshita et al.   PROTEOMICS

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

(2010) Matthew E. Gegg et al.   HUMAN MOLECULAR GENETICS

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

(2010) E. Ziviani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitophagy: the latest problem for Parkinson's disease

(2010) Cristofol Vives-Bauza et al.   TRENDS IN MOLECULAR MEDICINE

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Ubiquitin C-Terminal Electrophiles Are Activity-Based Probes for Identification and Mechanistic Study of Ubiquitin Conjugating Machinery

(2009) Kerry Routenberg Love et al.   ACS Chemical Biology

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF- B signaling

(2009) D. Sha et al.   HUMAN MOLECULAR GENETICS

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

(2008) Yongsung Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Combined kinase inhibition modulates parkin inactivation

(2008) E. Rubio de la Torre et al.   HUMAN MOLECULAR GENETICS

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

(2008) C. A. Gautier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The kinase domain of mitochondrial PINK1 faces the cytoplasm

(2008) C. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA