Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy
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Title
Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy
Authors
Keywords
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Journal
HUMAN MOLECULAR GENETICS
Volume 20, Issue 9, Pages 1726-1737
Publisher
Oxford University Press (OUP)
Online
2011-02-05
DOI
10.1093/hmg/ddr048
References
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Note: Only part of the references are listed.- p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both
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- Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin
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- PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
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- PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
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- The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
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