From the Cover: Alterations in Optineurin Expression and Localization in Pre-clinical Parkinson’s Disease Models

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Inflammatory and Cell Death Pathways in Brain and Peripheral Blood in Parkinson’s Disease

(2015) Beatrice Macchi et al.   CNS & Neurological Disorders-Drug Targets

Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons

(2015) Consiglia Pacelli et al.   CURRENT BIOLOGY

Development and function of the midbrain dopamine system: what we know and what we need to

(2015) G. B. Bissonette et al.   GENES BRAIN AND BEHAVIOR

shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson’s disease model

(2015) Alevtina D. Zharikov et al.   JOURNAL OF CLINICAL INVESTIGATION

Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats

(2015) Jang-Won Lee et al.   NEUROBIOLOGY OF AGING

A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin

(2015) Kapil Sirohi et al.   PLoS One

Innate Host Defense Requires TFEB-Mediated Transcription of Cytoprotective and Antimicrobial Genes

(2014) Orane Visvikis et al.   IMMUNITY

Mitochondrial DNA damage: Molecular marker of vulnerable nigral neurons in Parkinson's disease

(2014) Laurie H. Sanders et al.   NEUROBIOLOGY OF DISEASE

E50K-OPTN-Induced Retinal Cell Death Involves the Rab GTPase-Activating Protein, TBC1D17 Mediated Block in Autophagy

(2014) Madhavi Latha Somaraju Chalasani et al.   PLoS One

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

(2014) Yvette C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial DNA Damage as a Peripheral Biomarker for Mitochondrial Toxin Exposure in Rats

(2014) Laurie H. Sanders et al.   TOXICOLOGICAL SCIENCES

Structural basis for phosphorylation-triggered autophagic clearance ofSalmonella

(2013) Vladimir V. Rogov et al.   BIOCHEMICAL JOURNAL

How Parkinsonian Toxins Dysregulate the Autophagy Machinery

(2013) Ruben Dagda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in Parkinson's disease

(2013) Victor Tapias et al.   NEUROBIOLOGY OF AGING

Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy

(2013) Chen-Chen Tan et al.   NEUROBIOLOGY OF AGING

Rotenone Inhibits Autophagic Flux Prior to Inducing Cell Death

(2012) Burton J. Mader et al.   ACS Chemical Neuroscience

Optineurin immunoreactivity in neuronal nuclear inclusions of polyglutamine diseases (Huntington’s, DRPLA, SCA2, SCA3) and intranuclear inclusion body disease

(2012) Fumiaki Mori et al.   ACTA NEUROPATHOLOGICA

Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment

(2012) Jason R. Cannon et al.   EXPERIMENTAL NEUROLOGY

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

(2012) J. Korac et al.   JOURNAL OF CELL SCIENCE

Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database

(2012) Christina M. Lill et al.   PLoS Genetics

Optineurin inclusions occur in a minority of TDP-43 positive ALS and FTLD-TDP cases and are rarely observed in other neurodegenerative disorders

(2011) Tibor Hortobágyi et al.   ACTA NEUROPATHOLOGICA

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Brainstem and spinal cord motor neuron involvement with optineurin inclusions in proximal-dominant hereditary motor and sensory neuropathy

(2011) K. Fujita et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Localization of MAP1-LC3 in Vulnerable Neurons and Lewy Bodies in Brains of Patients With Dementia With Lewy Bodies

(2011) Shinji Higashi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Optineurin in neurodegenerative diseases

(2011) Tenshi Osawa et al.   NEUROPATHOLOGY

Optineurin in Huntington's disease intranuclear inclusions

(2011) Claudia Schwab et al.   NEUROSCIENCE LETTERS

Optineurin Is Required for CYLD-Dependent Inhibition of TNFα-Induced NF-κB Activation

(2011) Ananthamurthy Nagabhushana et al.   PLoS One

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

The Role of Environmental Exposures in Neurodegeneration and Neurodegenerative Diseases

(2011) Jason R. Cannon et al.   TOXICOLOGICAL SCIENCES

Pseudotype-dependent lentiviral transduction of astrocytes or neurons in the rat substantia nigra

(2010) Jason R. Cannon et al.   EXPERIMENTAL NEUROLOGY

Processing of Optineurin in Neuronal Cells

(2010) Xiang Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optineurin, a multifunctional protein involved in glaucoma, amyotrophic lateral sclerosis and antiviral signalling

(2010) Ghanshyam Swarup et al.   JOURNAL OF BIOSCIENCES

Mutations of optineurin in amyotrophic lateral sclerosis

(2010) Hirofumi Maruyama et al.   NATURE

Melatonin treatment potentiates neurodegeneration in a rat rotenone Parkinson's disease model

(2009) Victor Tapias et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A highly reproducible rotenone model of Parkinson's disease

(2009) Jason R. Cannon et al.   NEUROBIOLOGY OF DISEASE

Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology

(2009) Robert E. Drolet et al.   NEUROBIOLOGY OF DISEASE