Causes and consequences of genomic instability in laminopathies: Replication stress and interferon response

A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin

(2018) Ray Kreienkamp et al.   Cell Reports

Progerin sequestration of PCNA promotes replication fork collapse and mislocalization of XPA in laminopathy-related progeroid syndromes

(2017) Benjamin A. Hilton et al.   FASEB JOURNAL

Moonlighting at replication forks - a new life for homologous recombination proteins BRCA1, BRCA2 and RAD51

(2017) Arun Mouli Kolinjivadi et al.   FEBS LETTERS

Promising Targets for Cancer Immunotherapy: TLRs, RLRs, and STING-Mediated Innate Immune Pathways

(2017) Kai Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome

(2017) Keith Wheaton et al.   MOLECULAR AND CELLULAR BIOLOGY

The molecular architecture of lamins in somatic cells

(2017) Yagmur Turgay et al.   NATURE

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

RAD51 interconnects between DNA replication, DNA repair and immunity

(2017) Souparno Bhattacharya et al.   NUCLEIC ACIDS RESEARCH

cGAS is essential for the antitumor effect of immune checkpoint blockade

(2017) Hua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lamin A and microtubules collaborate to maintain nuclear morphology

(2017) Zeshan Tariq et al.   Nucleus

Lamin A and microtubules collaborate to maintain nuclear morphology

(2017) Zeshan Tariq et al.   Nucleus

Promoter hypermethylation as a mechanism for Lamin A/C silencing in a subset of neuroblastoma cells

(2017) Ines Rauschert et al.   PLoS One

DNA double-strand break repair: a tale of pathway choices

(2016) Jing Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient

(2016) Andrew M. Cobb et al.   AGING CELL

LMNA mutations resulting in lipodystrophy and HIV protease inhibitors trigger vascular smooth muscle cell senescence and calcification: Role of ZMPSTE24 downregulation

(2016) Pauline Afonso et al.   ATHEROSCLEROSIS

Nuclear Lamins in Cancer

(2016) Jerome Irianto et al.   Cellular and Molecular Bioengineering

Clinical Trial of the Protein Farnesylation Inhibitors Lonafarnib, Pravastatin, and Zoledronic Acid in Children With Hutchinson-Gilford Progeria SyndromeClinical Perspective

(2016) Leslie B. Gordon et al.   CIRCULATION

When your cap matters: structural insights into self vs non-self recognition of 5′ RNA by immunomodulatory host proteins

(2016) Daisy W Leung et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Causes and consequences of nuclear envelope alterations in tumour progression

(2016) Emily S. Bell et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha

(2016) Kevin Gesson et al.   GENOME RESEARCH

Recognition of Endogenous Nucleic Acids by the Innate Immune System

(2016) Axel Roers et al.   IMMUNITY

Editing of Cellular Self-RNAs by Adenosine Deaminase ADAR1 Suppresses Innate Immune Stress Responses

(2016) Cyril X. George et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome

(2016) Daniel Z Bar et al.   JOURNAL OF MEDICAL GENETICS

Replication stress: getting back on track

(2016) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication

(2016) Rentian Wu et al.   NUCLEIC ACIDS RESEARCH

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Laminopathies disrupt epigenomic developmental programs and cell fate

(2016) Jelena Perovanovic et al.   Science Translational Medicine

RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA

(2016) Christine Wolf et al.   Nature Communications

Replication stress: getting back on track

(2016) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease

(2016) Malgorzata Szelag et al.   Oncotarget

Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes

(2016) Ray Kreienkamp et al.   Oncotarget

Disruption of PCNA-lamins A/C interactions by prelamin A induces DNA replication fork stalling

(2016) Andrew M. Cobb et al.   Nucleus

Disruption of PCNA-lamins A/C interactions by prelamin A induces DNA replication fork stalling

(2016) Andrew M. Cobb et al.   Nucleus

Upregulated LINE-1 Activity in the Fanconi Anemia Cancer Susceptibility Syndrome Leads to Spontaneous Pro-inflammatory Cytokine Production

(2016) Christelle Brégnard et al.   EBioMedicine

Lamin A/C deficiency reduces circulating tumor cell resistance to fluid shear stress

(2015) Michael J. Mitchell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation

(2015) Yosef Gruenbaum et al.   Annual Review of Biochemistry

Identification of Gene Positioning Factors Using High-Throughput Imaging Mapping

(2015) Sigal Shachar et al.   CELL

DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity

(2015) Anetta Härtlova et al.   IMMUNITY

Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes

(2015) Elisa Cesarini et al.   JOURNAL OF CELL BIOLOGY

DNA2 drives processing and restart of reversed replication forks in human cells

(2015) Saravanabhavan Thangavel et al.   JOURNAL OF CELL BIOLOGY

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

(2015) Ralph Zellweger et al.   JOURNAL OF CELL BIOLOGY

Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins

(2015) Jennifer C. Harr et al.   JOURNAL OF CELL BIOLOGY

Various lamin A/C mutations alter expression profile of mesenchymal stem cells in mutation specific manner

(2015) Anna Malashicheva et al.   MOLECULAR GENETICS AND METABOLISM

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

NF-κB activation impairs somatic cell reprogramming in ageing

(2015) Clara Soria-Valles et al.   NATURE CELL BIOLOGY

Replication fork reversal in eukaryotes: from dead end to dynamic response

(2015) Kai J. Neelsen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of lamin A function increases chromatin dynamics in the nuclear interior

(2015) I. Bronshtein et al.   Nature Communications

All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype

(2015) Camilla Pellegrini et al.   Oncotarget

DNA-Damage-Induced Type I Interferon Promotes Senescence and Inhibits Stem Cell Function

(2015) Qiujing Yu et al.   Cell Reports

Phosphorylation of lamins determine their structural properties and signaling functions

(2015) Elin Torvaldson et al.   Nucleus

Phosphorylation of lamins determine their structural properties and signaling functions

(2015) Elin Torvaldson et al.   Nucleus

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Progeria: A Paradigm for Translational Medicine

(2014) Leslie B. Gordon et al.   CELL

RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response

(2014) Alexandre Maréchal et al.   CELL RESEARCH

Nuclear Deformability Constitutes a Rate-Limiting Step During Cell Migration in 3-D Environments

(2014) Patricia M. Davidson et al.   Cellular and Molecular Bioengineering

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin

(2014) Amnon Buxboim et al.   CURRENT BIOLOGY

STAT1 plays a role in TLR signal transduction and inflammatory responses

(2014) Kevin Luu et al.   IMMUNOLOGY AND CELL BIOLOGY

Laminopathy-inducing mutations reduce nuclear import of expressed prelamin A

(2014) T. Kiel et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial DNA induces inflammation and increases TLR9/NF-κB expression in lung tissue

(2014) JIAN-ZHENG ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery

(2014) Anar K. Murphy et al.   JOURNAL OF CELL BIOLOGY

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

Interphase phosphorylation of lamin A

(2014) V. Kochin et al.   JOURNAL OF CELL SCIENCE

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

(2014) Xin Cai et al.   MOLECULAR CELL

Enriched domain detector: a program for detection of wide genomic enrichment domains robust against local variations

(2014) Eivind Lund et al.   NUCLEIC ACIDS RESEARCH

Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells

(2014) D. Larrieu et al.   SCIENCE

Inflammation-driven carcinogenesis is mediated through STING

(2014) Jeonghyun Ahn et al.   Nature Communications

Transformation Resistance in a Premature Aging Disorder Identifies a Tumor-Protective Function of BRD4

(2014) Patricia Fernandez et al.   Cell Reports

Identification of differential protein interactors of lamin A and progerin

(2014) Nard Kubben et al.   Nucleus

Diverse lamin-dependent mechanisms interact to control chromatin dynamics

(2014) Daria Camozzi et al.   Nucleus

Embryonic expression of the common progeroid lamin A splice mutation arrests postnatal skin development

(2013) Tomás McKenna et al.   AGING CELL

Chromatin Position Effects Assayed by Thousands of Reporters Integrated in Parallel

(2013) Waseem Akhtar et al.   CELL

Genome Architecture: Domain Organization of Interphase Chromosomes

(2013) Wendy A. Bickmore et al.   CELL

When Lamins Go Bad: Nuclear Structure and Disease

(2013) Katherine H. Schreiber et al.   CELL

Lamin A/C Depletion Enhances DNA Damage-Induced Stalled Replication Fork Arrest

(2013) Mayank Singh et al.   MOLECULAR AND CELLULAR BIOLOGY

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells

(2013) J.-W. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Broken nuclei – lamins, nuclear mechanics, and disease

(2013) Patricia M. Davidson et al.   TRENDS IN CELL BIOLOGY

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

Mre11-Dependent Degradation of Stalled DNA Replication Forks Is Prevented by BRCA2 and PARP1

(2012) S. Ying et al.   CANCER RESEARCH

Inflamm-ageing

(2012) Elisa Cevenini et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Nuclear lamina defects cause ATM-dependent NF- B activation and link accelerated aging to a systemic inflammatory response

(2012) F. G. Osorio et al.   GENES & DEVELOPMENT

Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence

(2012) W. Meuleman et al.   GENOME RESEARCH

Double-Stranded RNA Induces Biphasic STAT1 Phosphorylation by both Type I Interferon (IFN)-Dependent and Type I IFN-Independent Pathways

(2012) J. Dempoya et al.   JOURNAL OF VIROLOGY

The nuclear lamins: flexibility in function

(2012) Brian Burke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear lamin functions and disease

(2012) Veronika Butin-Israeli et al.   TRENDS IN GENETICS

Stem cell depletion in Hutchinson-Gilford progeria syndrome

(2011) Ylva Rosengardten et al.   AGING CELL

Replication factor C1, the large subunit of replication factor C, is proteolytically truncated in Hutchinson-Gilford progeria syndrome

(2011) Hui Tang et al.   AGING CELL

Clinical and genetic heterogeneity in laminopathies

(2011) Anne T. Bertrand et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Tethered Genes Get Checked during Replication

(2011) Jiri Lukas et al.   CELL

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Regulating the levels of key factors in cell cycle and DNA repair: New pathways revealed by lamins

(2011) Abena B. Redwood et al.   CELL CYCLE

A dual role for A-type lamins in DNA double-strand break repair

(2011) Abena B. Redwood et al.   CELL CYCLE

A new pathway that regulates 53BP1 stability implicates Cathepsin L and vitamin D in DNA repair

(2011) Ignacio Gonzalez-Suarez et al.   EMBO JOURNAL

Analysis of protein dynamics at active, stalled, and collapsed replication forks

(2011) B. M. Sirbu et al.   GENES & DEVELOPMENT

The DNA Damage Response Induces IFN

(2011) Sabrina Brzostek-Racine et al.   JOURNAL OF IMMUNOLOGY

Nuclear lamins and laminopathies

(2011) Howard J. Worman   JOURNAL OF PATHOLOGY

Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome

(2011) Guang-Hui Liu et al.   NATURE

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice

(2011) V. Krishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells

(2011) K. Cao et al.   Science Translational Medicine

Increased plasticity of the nuclear envelope and hypermobility of telomeres due to the loss of A–type lamins

(2010) Winnok H. De Vos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Promotion of tumor development in prostate cancer by progerin

(2010) Yong Tang et al.   Cancer Cell International

Laminopathies and lamin-associated signaling pathways

(2010) Nadir M. Maraldi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pathways of mammalian replication fork restart

(2010) Eva Petermann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway

(2009) Ignacio Gonzalez-Suarez et al.   EMBO JOURNAL

Laminopathies and the long strange trip from basic cell biology to therapy

(2009) Howard J. Worman et al.   JOURNAL OF CLINICAL INVESTIGATION

Telomere length in Hutchinson-Gilford Progeria Syndrome

(2009) Michelle L. Decker et al.   MECHANISMS OF AGEING AND DEVELOPMENT

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Ageing-related chromatin defects through loss of the NURD complex

(2009) Gianluca Pegoraro et al.   NATURE CELL BIOLOGY

Transient Anomalous Diffusion of Telomeres in the Nucleus of Mammalian Cells

(2009) I. Bronstein et al.   PHYSICAL REVIEW LETTERS

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

(2008) T. Dechat et al.   GENES & DEVELOPMENT

The nuclear lamina promotes telomere aggregation and centromere peripheral localization during senescence of human mesenchymal stem cells

(2008) V. Raz et al.   JOURNAL OF CELL SCIENCE

HGPS and related premature aging disorders: From genomic identification to the first therapeutic approaches

(2008) Sandrine Pereira et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Suppression of Proliferative Defects Associated with Processing-defective Lamin A Mutants by hTERT or Inactivation of p53

(2008) Brian A. Kudlow et al.   MOLECULAR BIOLOGY OF THE CELL

A forward chemical genetic screen reveals an inhibitor of the Mre11–Rad50–Nbs1 complex

(2008) Aude Dupré et al.   Nature Chemical Biology

Phenotype and Course of Hutchinson–Gilford Progeria Syndrome

(2008) Melissa A. Merideth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Accelerated telomere shortening and replicative senescence in human fibroblasts overexpressing mutant and wild-type lamin A

(2007) Shurong Huang et al.   EXPERIMENTAL CELL RESEARCH

Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A

(2007) Yiyong Liu et al.   FASEB JOURNAL