Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 36, Issue -, Pages 133-141Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2016.02.001
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Funding
- National Institute of Health (NIH) [R01AI107056, R01AI123926, R01AI114654, U191099565, U19AI109945, U19AI109664]
- Department of the Defense, Defense Threat Reduction Agency [HDTRA1-14-0013, HDTRA1-12-1-0051]
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Cytosolic recognition of viral RNA is important for host innate immune responses. Differential recognition of self vs non-self RNA is a considerable challenge as the inability to differentiate may trigger aberrant immune responses. Recent work identified the composition of the RNA 5', including the 5' cap and its methylation state, as an important determinant of recognition by the host. Recent studies have advanced our understanding of the modified 5' RNA recognition and viral antagonism of RNA receptors. Here, we will discuss RIG-I and IFIT proteins as examples of host proteins that detect dsRNA and ssRNA, respectively.
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