Moonlighting at replication forks - a new life for homologous recombination proteins BRCA1, BRCA2 and RAD51

Mechanism and regulation of DNA end resection in eukaryotes

(2016) Lorraine S. Symington   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Studying essential DNA metabolism proteins in Xenopus egg extract

(2016) Vincenzo Sannino et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

POLD3 Is Haploinsufficient for DNA Replication in Mice

(2016) Matilde Murga et al.   MOLECULAR CELL

Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability

(2016) Julian Spies et al.   MOLECULAR CELL

Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection

(2016) Roopesh Anand et al.   MOLECULAR CELL

Break-induced telomere synthesis underlies alternative telomere maintenance

(2016) Robert L. Dilley et al.   NATURE

Replication fork stability confers chemoresistance in BRCA-deficient cells

(2016) Arnab Ray Chaudhuri et al.   NATURE

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

(2016) Serena Nik-Zainal et al.   NATURE

Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression

(2016) Antoine Aze et al.   NATURE CELL BIOLOGY

Replication stress: getting back on track

(2016) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells

(2016) Akshay K. Ahuja et al.   Nature Communications

Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies

(2016) Xia Ding et al.   Nature Communications

Replication stress: getting back on track

(2016) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair

(2016) Zeina Kais et al.   Cell Reports

Priming for tolerance and cohesion at replication forks

(2016) Dana Branzei et al.   Nucleus

Priming for tolerance and cohesion at replication forks

(2016) Dana Branzei et al.   Nucleus

Linking DNA polymerase theta structure and function in health and disease

(2015) Kelly Beagan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Alternative solutions and new scenarios for translesion DNA synthesis by human PrimPol

(2015) María I. Martínez-Jiménez et al.   DNA REPAIR

DNA End Resection: Nucleases Team Up with the Right Partners to Initiate Homologous Recombination

(2015) Petr Cejka   JOURNAL OF BIOLOGICAL CHEMISTRY

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

(2015) Ralph Zellweger et al.   JOURNAL OF CELL BIOLOGY

Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function

(2015) Felix Y. Feng et al.   MOLECULAR CELL

Error-Free DNA Damage Tolerance and Sister Chromatid Proximity during DNA Replication Rely on the Polα/Primase/Ctf4 Complex

(2015) Marco Fumasoni et al.   MOLECULAR CELL

A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination

(2015) Anderson T. Wang et al.   MOLECULAR CELL

Replication stress activates DNA repair synthesis in mitosis

(2015) Sheroy Minocherhomji et al.   NATURE

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

Replication fork reversal in eukaryotes: from dead end to dynamic response

(2015) Kai J. Neelsen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation

(2015) María Belén Vallerga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51

(2015) Najim Ameziane et al.   Nature Communications

Mta2 promotes Tipin-dependent maintenance of replication fork integrity

(2014) Alessia Errico et al.   CELL CYCLE

Mutational signatures: the patterns of somatic mutations hidden in cancer genomes

(2014) Ludmil B Alexandrov et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Non-homologous end joining: Emerging themes and unanswered questions

(2014) Sarvan Kumar Radhakrishnan et al.   DNA REPAIR

Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans

(2014) S. F. Roerink et al.   GENOME RESEARCH

Replisome-mediated Translesion Synthesis and Leading Strand Template Lesion Skipping Are Competing Bypass Mechanisms

(2014) Carolina B. Gabbai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks

(2014) Elda Cannavo et al.   NATURE

A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites

(2014) Wouter Koole et al.   Nature Communications

53BP1 Mediates Productive and Mutagenic DNA Repair through Distinct Phosphoprotein Interactions

(2013) Elsa Callen et al.   CELL

ATR phosphorylates SMARCAL1 to prevent replication fork collapse

(2013) F. B. Couch et al.   GENES & DEVELOPMENT

RIF1 Counteracts BRCA1-mediated End Resection during DNA Repair

(2013) Lin Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

(2013) J. Ross Chapman et al.   MOLECULAR CELL

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Mechanisms of resistance to therapies targeting BRCA-mutant cancers

(2013) Christopher J Lord et al.   NATURE MEDICINE

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

(2013) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reconstitution of recombination-associated DNA synthesis with human proteins

(2013) Jessica L. Sneeden et al.   NUCLEIC ACIDS RESEARCH

53BP1 Regulates DSB Repair Using Rif1 to Control 5' End Resection

(2013) M. Zimmermann et al.   SCIENCE

Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching

(2013) M. Di Virgilio et al.   SCIENCE

Rescuing Stalled or Damaged Replication Forks

(2013) J. T. P. Yeeles et al.   Cold Spring Harbor Perspectives in Biology

Deciphering Signatures of Mutational Processes Operative in Human Cancer

(2013) Ludmil B. Alexandrov et al.   Cell Reports

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Mechanisms of replication fork protection: a safeguard for genome stability

(2012) Alessia Errico et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication

(2012) R. Betous et al.   GENES & DEVELOPMENT

Preparation and use of Xenopus egg extracts to study DNA replication and chromatin associated proteins

(2012) Peter J. Gillespie et al.   METHODS

Rad51 Paralog Complexes BCDX2 and CX3 Act at Different Stages in the BRCA1-BRCA2-Dependent Homologous Recombination Pathway

(2012) J. Chun et al.   MOLECULAR AND CELLULAR BIOLOGY

Polyubiquitinated PCNA Recruits the ZRANB3 Translocase to Maintain Genomic Integrity after Replication Stress

(2012) Alberto Ciccia et al.   MOLECULAR CELL

BRCA1 Functions Independently of Homologous Recombination in DNA Interstrand Crosslink Repair

(2012) Samuel F. Bunting et al.   MOLECULAR CELL

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Reconstitution of DNA repair synthesis in vitro and the role of polymerase and helicase activities

(2011) Marek Sebesta et al.   DNA REPAIR

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

(2011) Karen A Gelmon et al.   LANCET ONCOLOGY

Functional Interplay of the Mre11 Nuclease and Ku in the Response to Replication-Associated DNA Damage

(2011) S. S. Foster et al.   MOLECULAR AND CELLULAR BIOLOGY

RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks

(2011) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Escherichia coli Replisome Is Inherently DNA Damage Tolerant

(2011) J. T. P. Yeeles et al.   SCIENCE

BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability

(2011) A. Aly et al.   Journal of Molecular Cell Biology

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

(2010) Eleni P Mimitou et al.   EMBO JOURNAL

Differences in the DNA replication of unicellular eukaryotes and metazoans: known unknowns

(2010) Alessia Errico et al.   EMBO REPORTS

The MRN complex in double-strand break repair and telomere maintenance

(2010) Brandon J. Lamarche et al.   FEBS LETTERS

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

(2010) M William Audeh et al.   LANCET

Homologous Recombination Restarts Blocked Replication Forks at the Expense of Genome Rearrangements by Template Exchange

(2010) Sarah Lambert et al.   MOLECULAR CELL

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

(2010) Eva Petermann et al.   MOLECULAR CELL

Purified human BRCA2 stimulates RAD51-mediated recombination

(2010) Ryan B. Jensen et al.   NATURE

Maintaining genome stability at the replication fork

(2010) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA

(2010) Jie Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA

(2010) Tina Thorslund et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

(2010) Peter Bouwman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cooperation of RAD51 and RAD54 in regression of a model replication fork

(2010) Dmitry V. Bugreev et al.   NUCLEIC ACIDS RESEARCH

Replication and Recombination Factors Contributing to Recombination-Dependent Bypass of DNA Lesions by Template Switch

(2010) Fabio Vanoli et al.   PLoS Genetics

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination

(2009) Helen E Bryant et al.   EMBO JOURNAL

Multiplicity of DNA end resection machineries in chromosome break repair

(2009) H. Niu et al.   GENES & DEVELOPMENT

The active form of DNA polymerase V is UmuD′2C–RecA–ATP

(2009) Qingfei Jiang et al.   NATURE

Replication fork reversal and the maintenance of genome stability

(2009) J. Atkinson et al.   NUCLEIC ACIDS RESEARCH

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

Mre11 Nuclease Activity Has Essential Roles in DNA Repair and Genomic Stability Distinct from ATM Activation

(2008) Jeffrey Buis et al.   CELL

Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair

(2008) Markus Räschle et al.   CELL

Mre11–Rad50–Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity

(2008) Ali Jazayeri et al.   EMBO JOURNAL

Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair

(2008) Longchuan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse embryonic stem cell–based functional assay to evaluate mutations in BRCA2

(2008) Sergey G Kuznetsov et al.   NATURE MEDICINE

Cell-cycle coordination between DNA replication and recombination revealed by a vertebrate N-end rule degron-Rad51

(2008) Xinyi Su et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY