Replication fork reversal in eukaryotes: from dead end to dynamic response

Human RecQ Helicases in DNA Repair, Recombination, and Replication

(2014) Deborah L. Croteau et al.   Annual Review of Biochemistry

The histone-fold complex MHF is remodeled by FANCM to recognize branched DNA and protect genome stability

(2014) David Fox et al.   CELL RESEARCH

Metabolism of DNA secondary structures at the eukaryotic replication fork

(2014) Ana María León-Ortiz et al.   DNA REPAIR

Tolerating DNA damage during eukaryotic chromosome replication

(2014) Irene Saugar et al.   EXPERIMENTAL CELL RESEARCH

Poly(ADP-Ribosyl) Glycohydrolase Prevents the Accumulation of Unusual Replication Structures during Unperturbed S Phase

(2014) Arnab Ray Chaudhuri et al.   MOLECULAR AND CELLULAR BIOLOGY

Visualization of recombination-mediated damage bypass by template switching

(2014) Michele Giannattasio et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human MUS81-EME2 can cleave a variety of DNA structures including intact Holliday junction and nicked duplex

(2014) Tamir Amangyeld et al.   NUCLEIC ACIDS RESEARCH

Completion of DNA replication inEscherichia coli

(2014) Brian M. Wendel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication

(2014) Marija Maric et al.   SCIENCE

Polyubiquitylation drives replisome disassembly at the termination of DNA replication

(2014) Sara Priego Moreno et al.   SCIENCE

MUS81-EME2 Promotes Replication Fork Restart

(2014) Alessandra Pepe et al.   Cell Reports

Resolving branched DNA intermediates with structure-specific nucleases during replication in eukaryotes

(2013) Ulrich Rass   CHROMOSOMA

Rad51 replication fork recruitment is required for DNA damage tolerance

(2013) Román González-Prieto et al.   EMBO JOURNAL

ATR phosphorylates SMARCAL1 to prevent replication fork collapse

(2013) F. B. Couch et al.   GENES & DEVELOPMENT

Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template

(2013) K. J. Neelsen et al.   GENES & DEVELOPMENT

Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

(2013) Kai J. Neelsen et al.   JOURNAL OF CELL BIOLOGY

Replication Stress-Induced Genome Instability: The Dark Side of Replication Maintenance by Homologous Recombination

(2013) Antony M. Carr et al.   JOURNAL OF MOLECULAR BIOLOGY

The DNA Translocase FANCM/MHF Promotes Replication Traverse of DNA Interstrand Crosslinks

(2013) Jing Huang et al.   MOLECULAR CELL

HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis

(2013) Carrie A. Adelman et al.   NATURE

ERCC1 and MUS81–EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis

(2013) Valeria Naim et al.   NATURE CELL BIOLOGY

Regulation of Mus81–Eme1 Holliday junction resolvase in response to DNA damage

(2013) Pierre-Marie Dehé et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

(2013) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Friedreich's ataxia–associated GAA repeats induce replication-fork reversal and unusual molecular junctions

(2013) Cindy Follonier et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phosphorylation of a C-terminal auto-inhibitory domain increases SMARCAL1 activity

(2013) C. Carroll et al.   NUCLEIC ACIDS RESEARCH

Substrate specificity of the MUS81-EME2 structure selective endonuclease

(2013) A. Pepe et al.   NUCLEIC ACIDS RESEARCH

Strand invasion by HLTF as a mechanism for template switch in fork rescue

(2013) Peter Burkovics et al.   NUCLEIC ACIDS RESEARCH

Single-molecule sorting reveals how ubiquitylation affects substrate recognition and activities of FBH1 helicase

(2013) Tokiha Masuda-Ozawa et al.   NUCLEIC ACIDS RESEARCH

FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress

(2013) Kasper Fugger et al.   Nature Communications

Substrate-Selective Repair and Restart of Replication Forks by DNA Translocases

(2013) Rémy Bétous et al.   Cell Reports

Cell-Cycle Kinases Coordinate the Resolution of Recombination Intermediates with Chromosome Segregation

(2013) Joao Matos et al.   Cell Reports

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

The Intra-S Phase Checkpoint Targets Dna2 to Prevent Stalled Replication Forks from Reversing

(2012) Jiazhi Hu et al.   CELL

ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response

(2012) R. Weston et al.   GENES & DEVELOPMENT

SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication

(2012) R. Betous et al.   GENES & DEVELOPMENT

Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway

(2012) H. Kim et al.   GENES & DEVELOPMENT

The DNA translocase activity of FANCM protects stalled replication forks

(2012) Andrew N. Blackford et al.   HUMAN MOLECULAR GENETICS

2D gels and their third-dimension potential

(2012) Jorge B. Schvartzman et al.   METHODS

Preventing Replication Stress to Maintain Genome Stability: Resolving Conflicts between Replication and Transcription

(2012) Rodrigo Bermejo et al.   MOLECULAR CELL

The HARP-like Domain-Containing Protein AH2/ZRANB3 Binds to PCNA and Participates in Cellular Response to Replication Stress

(2012) Jingsong Yuan et al.   MOLECULAR CELL

Polyubiquitinated PCNA Recruits the ZRANB3 Translocase to Maintain Genomic Integrity after Replication Stress

(2012) Alberto Ciccia et al.   MOLECULAR CELL

Chromatin replication and epigenome maintenance

(2012) Constance Alabert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

(2012) Arnab Ray Chaudhuri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The WRN and MUS81 proteins limit cell death and genome instability following oncogene activation

(2012) I Murfuni et al.   ONCOGENE

Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress

(2012) R M Jones et al.   ONCOGENE

Direct Observation of Stalled Fork Restart via Fork Regression in the T4 Replication System

(2012) M. Manosas et al.   SCIENCE

Replication Fork Reversal after Replication–Transcription Collision

(2012) Anne L. De Septenville et al.   PLoS Genetics

The Werner and Bloom Syndrome Proteins Help Resolve Replication Blockage by Converting (Regressed) Holliday Junctions to Functional Replication Forks

(2011) Amrita Machwe et al.   BIOCHEMISTRY

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis

(2011) Joao Matos et al.   CELL

The Replication Checkpoint Protects Fork Stability by Releasing Transcribed Genes from Nuclear Pores

(2011) Rodrigo Bermejo et al.   CELL

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

The role of shelterin in maintaining telomere integrity

(2011) Maria Pia Longhese   Frontiers in Bioscience-Landmark

Coordinated protein and DNA remodeling by human HLTF on stalled replication fork

(2011) Y. J. Achar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The FANCM family of DNA helicases/translocases

(2010) Matthew C. Whitby   DNA REPAIR

Role of yeast Rad5 and its human orthologs, HLTF and SHPRH in DNA damage tolerance

(2010) Ildiko Unk et al.   DNA REPAIR

ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery

(2010) Francesca Ammazzalorso et al.   EMBO JOURNAL

ATR activation and replication fork restart are defective in FANCM-deficient cells

(2010) Rebekka A Schwab et al.   EMBO JOURNAL

Molecular Cooperation between the Werner Syndrome Protein and Replication Protein A in Relation to Replication Fork Blockage

(2010) Amrita Machwe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories

(2010) Xin Quan Ge et al.   JOURNAL OF CELL BIOLOGY

Response of the Bacteriophage T4 Replisome to Noncoding Lesions and Regression of a Stalled Replication Fork

(2010) Scott W. Nelson et al.   JOURNAL OF MOLECULAR BIOLOGY

Termination at sTop2

(2010) Robert C. Alver et al.   MOLECULAR CELL

Replication Termination at Eukaryotic Chromosomes Is Mediated by Top2 and Occurs at Genomic Loci Containing Pausing Elements

(2010) Daniele Fachinetti et al.   MOLECULAR CELL

A Genome-wide Camptothecin Sensitivity Screen Identifies a Mammalian MMS22L-NFKBIL2 Complex Required for Genomic Stability

(2010) Brenda C. O'Connell et al.   MOLECULAR CELL

Homologous Recombination Restarts Blocked Replication Forks at the Expense of Genome Rearrangements by Template Exchange

(2010) Sarah Lambert et al.   MOLECULAR CELL

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

(2010) Eva Petermann et al.   MOLECULAR CELL

A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability

(2010) Zhijiang Yan et al.   MOLECULAR CELL

Mechanisms of trinucleotide repeat instability during human development

(2010) Cynthia T. McMurray   NATURE REVIEWS GENETICS

Maintaining genome stability at the replication fork

(2010) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cooperation of RAD51 and RAD54 in regression of a model replication fork

(2010) Dmitry V. Bugreev et al.   NUCLEIC ACIDS RESEARCH

Annealing helicase 2 (AH2), a DNA-rewinding motor with an HNH motif

(2010) T. Yusufzai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair

(2009) Jennifer M. Svendsen et al.   CELL

Human SLX4 Is a Holliday Junction Resolvase Subunit that Binds Multiple DNA Repair/Recombination Endonucleases

(2009) Samira Fekairi et al.   CELL

FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling

(2009) Sarah Luke-Glaser et al.   EMBO JOURNAL

The annealing helicase HARP protects stalled replication forks

(2009) J. Yuan et al.   GENES & DEVELOPMENT

The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart

(2009) A. Ciccia et al.   GENES & DEVELOPMENT

The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks

(2009) C. E. Bansbach et al.   GENES & DEVELOPMENT

The annealing helicase HARP is recruited to DNA repair sites via an interaction with RPA

(2009) T. Yusufzai et al.   GENES & DEVELOPMENT

Identification of SMARCAL1 as a Component of the DNA Damage Response

(2009) Lisa Postow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities

(2009) Kasper Fugger et al.   JOURNAL OF CELL BIOLOGY

Fbh1 Limits Rad51-Dependent Recombination at Blocked Replication Forks

(2009) A. Lorenz et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of Double-Stranded DNA Translocase Activity of Human HLTF in Replication of Damaged DNA

(2009) A. Blastyak et al.   MOLECULAR AND CELLULAR BIOLOGY

Replication fork reversal and the maintenance of genome stability

(2009) J. Atkinson et al.   NUCLEIC ACIDS RESEARCH

Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair

(2008) Markus Räschle et al.   CELL

FANCM of the Fanconi anemia core complex is required for both monoubiquitination and DNA repair

(2008) Yutong Xue et al.   HUMAN MOLECULAR GENETICS

The Human RecQ Helicases, BLM and RECQ1, Display Distinct DNA Substrate Specificities

(2008) Venkateswarlu Popuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Minichromosome Maintenance Proteins Interact with Checkpoint and Recombination Proteins To Promote S-Phase Genome Stability

(2008) J. M. Bailis et al.   MOLECULAR AND CELLULAR BIOLOGY

The Fanconi Anemia Protein FANCM Can Promote Branch Migration of Holliday Junctions and Replication Forks

(2008) Kerstin Gari et al.   MOLECULAR CELL

FANCM and FAAP24 Function in ATR-Mediated Checkpoint Signaling Independently of the Fanconi Anemia Core Complex

(2008) Spencer J. Collis et al.   MOLECULAR CELL

The replication fork trap and termination of chromosome replication

(2008) Iain G. Duggin et al.   MOLECULAR MICROBIOLOGY

Regression supports two mechanisms of fork processing in phage T4

(2008) D. T. Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination

(2008) I. Unk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks

(2008) A. Motegi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Remodeling of DNA replication structures by the branch point translocase FANCM

(2008) K. Gari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HARP Is an ATP-Driven Annealing Helicase

(2008) T. Yusufzai et al.   SCIENCE

Cleavage of Stalled Forks by Fission Yeast Mus81/Eme1 in Absence of DNA Replication Checkpoint

(2007) Benoît Froget et al.   MOLECULAR BIOLOGY OF THE CELL