The chemical, genetic and immunological basis of idiosyncratic drug–induced liver injury

Characterization of amoxicillin- and clavulanic acid-specific T cells in patients with amoxicillin-clavulanate-induced liver injury

(2015) Seung-Hyun Kim et al.   HEPATOLOGY

Treatment of PD-1−/−mice with amodiaquine and anti-CTLA4 leads to liver injury similar to idiosyncratic liver injury in patients

(2015) Imir G. Metushi et al.   HEPATOLOGY

Pharmacogenetic testing in idiosyncratic drug-induced liver injury: current role in clinical practice

(2015) Guruprasad P. Aithal   LIVER INTERNATIONAL

Activation of Flucloxacillin-Specific CD8+ T-Cells With the Potential to Promote Hepatocyte Cytotoxicity in a Mouse Model

(2015) Ryan Nattrass et al.   TOXICOLOGICAL SCIENCES

Superoxide Dismutase Gene (SOD1, SOD2, and SOD3) Polymorphisms and Antituberculosis Drug-induced Hepatitis

(2015) Sang-Hoon Kim et al.   Allergy Asthma & Immunology Research

T Cells Infiltrate the Liver and Kill Hepatocytes in HLA-B ∗ 57:01-Associated Floxacillin-Induced Liver Injury

(2014) Natascha Wuillemin et al.   AMERICAN JOURNAL OF PATHOLOGY

Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

(2014) Michael D. Aleo et al.   HEPATOLOGY

A Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen Micropolymorphism

(2014) Yu Chih Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drug-Induced Endoplasmic Reticulum and Oxidative Stress Responses Independently Sensitize Toward TNFα-Mediated Hepatotoxicity

(2014) Lisa Fredriksson et al.   TOXICOLOGICAL SCIENCES

β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis

(2013) Rosalind E. Jenkins et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Detection of anti-isoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced liver failure

(2013) Imir G. Metushi et al.   HEPATOLOGY

Associations Between HLA-DRB1*0102, HLA-B*5801, and Hepatotoxicity During Initiation of Nevirapine-Containing Regimens in South Africa

(2013) Elizabeth Phillips et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Decoding cell death signals in liver inflammation

(2013) Catherine Brenner et al.   JOURNAL OF HEPATOLOGY

Pharmacogenomics of severe cutaneous adverse reactions and drug-induced liver injury

(2013) Nahoko Kaniwa et al.   JOURNAL OF HUMAN GENETICS

HLA Haplotype Determines Hapten or p-i T Cell Reactivity to Flucloxacillin

(2013) N. Wuillemin et al.   JOURNAL OF IMMUNOLOGY

HLA Alleles Influence the Clinical Signature of Amoxicillin-Clavulanate Hepatotoxicity

(2013) Camilla Stephens et al.   PLoS One

Bioinformatic Analysis of 302 Reactive Metabolite Target Proteins. Which Ones Are Important for Cell Death?

(2013) Robert P. Hanzlik et al.   TOXICOLOGICAL SCIENCES

Acute cholestatic hepatitis caused by amoxicillin/clavulanate

(2013) Daniel Oliveira Beraldo   WORLD JOURNAL OF GASTROENTEROLOGY

Abacavir induces loading of novel self-peptides into HLA-B*57

(2012) Michael A. Norcross et al.   AIDS

Role of immune reactions in drug-induced liver injury (DILI)

(2012) Cynthia Ju et al.   DRUG METABOLISM REVIEWS

NAT2 genotype guided regimen reduces isoniazid-induced liver injury and early treatment failure in the 6-month four-drug standard treatment of tuberculosis: A randomized controlled trial for pharmacogenetics-based therapy

(2012) Junichi Azuma et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury

(2012) Manal M. Monshi et al.   HEPATOLOGY

The Generation, Detection, and Effects of Reactive Drug Metabolites

(2012) Andrew V. Stachulski et al.   MEDICINAL RESEARCH REVIEWS

Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs

(2012) Thomas J. Urban et al.   Pharmacogenetics and Genomics

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire

(2012) D. A. Ostrov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Development of In Vitro Culture Methods to Characterize Primary T-Cell Responses to Drugs

(2012) Lee Faulkner et al.   TOXICOLOGICAL SCIENCES

Protective Effects of Exogenous Glutathione and Related Thiol Compounds against Drug-Induced Liver Injury

(2011) Yasuhiro Masubuchi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Case Definition and Phenotype Standardization in Drug-Induced Liver Injury

(2011) G P Aithal et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A Fresh Look at the Mechanism of Isoniazid-Induced Hepatotoxicity

(2011) I G Metushi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles

(2011) M. Isabel Lucena et al.   GASTROENTEROLOGY

HLA-DQA1*02:01 Is a Major Risk Factor for Lapatinib-Induced Hepatotoxicity in Women With Advanced Breast Cancer

(2011) Colin F. Spraggs et al.   JOURNAL OF CLINICAL ONCOLOGY

Characteristics of Idiosyncratic Drug-induced Liver Injury in Children

(2011) Jean P. Molleston et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Managing the challenge of chemically reactive metabolites in drug development

(2011) B. Kevin Park et al.   NATURE REVIEWS DRUG DISCOVERY

Approaches for the rapid identification of drug metabolites in early clinical studies

(2011) Gordon J Dear et al.   Bioanalysis

Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury

(2010) Peter T. Donaldson et al.   JOURNAL OF HEPATOLOGY

A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury

(2010) Jonathan B Singer et al.   NATURE GENETICS

Drug-induced liver injury: past, present and future

(2010) Ann K Daly   PHARMACOGENOMICS

Fulminant Liver Failure After Vancomycin in a Sulfasalazine-Induced DRESS Syndrome: Fatal Recurrence After Liver Transplantation

(2009) M. Mennicke et al.   AMERICAN JOURNAL OF TRANSPLANTATION

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

(2009) Ann K Daly et al.   NATURE GENETICS

Epidemiology of Idiosyncratic Drug-Induced Liver Injury

(2009) Lauren Bell et al.   SEMINARS IN LIVER DISEASE

Bile-acid-induced cell injury and protection

(2009) Maria J Perez et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Using controlled clinical trials to learn more about acute drug-induced liver injury

(2008) Paul B. Watkins et al.   HEPATOLOGY

GlutathioneS-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury

(2008) M. Isabel Lucena et al.   HEPATOLOGY

Screening and characterization of reactive metabolites using glutathione ethyl ester in combination with Q-trap mass spectrometry

(2008) Bo Wen et al.   JOURNAL OF MASS SPECTROMETRY

HLA-B*5701 Screening for Hypersensitivity to Abacavir

(2008) Simon Mallal et al.   NEW ENGLAND JOURNAL OF MEDICINE